--- type: "WebPage" title: "Laboratory analysis of 1,4-dioxane" description: "You want to analyze or measure 1.4-dioxane in your products? What is 1.4-dioxane? The chemical substance 1.4-dioxane is a cyclic ether with a molecular weight of 88.1 g/mol (C4H8O2, Chemical Abstracts Service Registry Number 123-91-1) that has many chemical properties...." resource: "https://filab.fr/en/our-services/our-analysis-services/chemical-analysis-laboratory/laboratory-analysis-of-14-dioxane/" tags: ["EN", "pll_627e15ddb3a5a", "Anaïs DECAUX"] timestamp: "2025-12-31T08:44:32Z" published: "2022-06-15T14:07:40Z" language: "en" author: "bwa" --- # Laboratory analysis of 1,4-dioxane ## You want to analyze or measure 1.4-dioxane in your products? ### What is 1.4-dioxane? The chemical substance 1.4-dioxane is a cyclic ether with a molecular weight of 88.1 g/mol (C4H8O2, Chemical Abstracts Service Registry Number 123-91-1) that has many chemical properties. Consumers may encounter this chemical in their everyday products. ### In what context do you encounter 1.4-dioxane?  To answer this question, let’s start with the ICH Q3C definition. According to the [ICH Q3C](https://filab.fr/en/sectors-of-activity/health-pharmaceutical-cosmetics/laboratory-analyis-ich-q3c.md), 1,4-dioxane is a residual solvent in pharmaceutical products. They are defined as volatile organic chemicals used or produced in the manufacture of pharmaceutical products or drug substances. However, it is also found in soils since this liquid is miscible in water. However, this substance is not limited to the environmental and pharmaceutical sector.  Indeed, you can find 1.4 dioxane in hair shampoos, hand soaps, shower gels…etc. Cosmetic products are regularly tested for [1.4-dioxane in their products](https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics/determination-of-14-dioxane-in-cosmetic-products.md). ### 1.4 dioxane in cosmetic products? 1.4 dioxane is found in certain [cosmetic products](https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics.md) such as shampoos, deodorants and toothpastes. Here, 1,4 dioxane is used as a foaming agent in cosmetic products. 1,4-Dioxane is derived from the synthesis of epoxyethane and is considered to be a degradation product obtained during the manufacturing process of a cosmetic product. ![](https://filab.fr/wp-content/uploads/2024/10/cosmetiques-soins-1024x512.png) #### FILAB is COFRAC ISO 17025 accredited for the determination of phthalates DIBP, DnBP, DPP in limit test at 1 mg/kg by GC-MS, in cosmetic products such as lotion. ## The FILAB laboratory supports manufacturers in the analysis of 1.4-dioxane? The analysis of 1,4-dioxane can be complex and appropriate sample preparation methods must be used to achieve low reporting thresholds. This is due to the numerous chemical properties of this substance.  FILAB Laboratory is able to assist you with different analytical methods in the sample preparation but especially in the analysis of 1,4-dioxane in your products:  ## Analysis services Analysis and determination of 1,4-dioxane in your cosmetics by chromatographic techniques: [HS-GCMS, GCMS, HPLC-UV](https://filab.fr/en/our-technical-resources.md)...  Determination of preservatives (phenoxyethanol, [parabens](https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics/parabens-analysis-laboratory.md), chlorphenesin...) by HPLC-UV, HPLC-MSMS and GC-MS [Expertise on non-conformities](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-failures.md): [particles](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-particulate-contaminant.md), [deposits](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-deposit-contamination.md), [unknown spike](https://filab.fr/en/laboratory-mass-spectrometry-unknown-spike-analysis.md), degradation of materials... 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[Analytical validation according to ICH Q2](https://filab.fr/en/our-services/rd/life-cycle-of-an-analytical-method-in-the-laboratory/laboratory-analytical-method-validation/) [Deformation](https://filab.fr/en/our-services/our-expertise-services/laboratory-deformulation-analysis-reverse-engineering.md) [Determination of active ingredients](https://filab.fr/en/sectors-of-activity/health-pharmaceutical-cosmetics/laboratory-analysis-active-ingredients.md): organic and mineral sunscreens, vitamins, ... Compatibility study ([container/content interaction](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-container-contents-interactions.md), [extractables and relargables](https://filab.fr/en/our-services/our-expertise-services/laboratory-extractable-leachable-testing/extractable-leachable-analysis.md)) ## our technical resources [Mass Spectrometry ](https://filab.fr/en/our-technical-resources/laboratory-analysis-mass-spectrometry.md) [HS-GC/MS](https://filab.fr/en/our-technical-resources/gas-chromatography-analysis-lab-gc/gc-ms-hs-gc-ms-and-tdu-gc-ms-laboratory.md) [ICP-MS](https://filab.fr/en/our-technical-resources/icp-ms-analysis-laboratory.md) [MALDI-TOF](https://filab.fr/en/our-technical-resources/maldi-tof-laboratory-analysis.md) [LC-QTOf](https://filab.fr/en/our-technical-resources/laboratory-for-lc-qtof-analysis.md) [Liquid Chromatography (HPLC or LC-MS and HPLC-MS/MS)](https://filab.fr/en/our-technical-resources/laboratory-analysis-uplc/laboratory-analysis-hplc-lcms.md)