--- type: "WebPage" title: "Analysis of nitrosamines by GC-TEA" description: "As a manufacturer, you would like to carry out a GC-TEA analysis of nitrosamines. What are nitrosamines ? Nitrosamines belong to a family of oxidized, nitrogenous chemical compounds. Whether deliberately present or not, nitrosamines are found in a number of..." resource: "https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/analysis-nitrosamines-gc-tea/" tags: ["EN", "pll_666852405a756"] timestamp: "2026-03-16T11:19:39Z" published: "2024-07-29T12:33:24Z" language: "en" author: "Laure Durieux" --- # Analysis of nitrosamines by GC-TEA ## As a manufacturer, you would like to carry out a GC-TEA analysis of nitrosamines. ### What are nitrosamines ? Nitrosamines belong to a family of oxidized, nitrogenous chemical compounds. Whether deliberately present or not, nitrosamines are found in a number of industrial products, including pharmaceuticals, cosmetics and plastics.    [pharmaceuticals](https://filab.fr/en/sectors-of-activity/health-pharmaceutical-cosmetics/laboratory-analysis-medication.md), [produits cosmetics](https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics.md) and [plastics](https://filab.fr/en/our-services/our-analysis-services/polymer-materials-analysis-laboratory/plastics-processing-polymers.md). ### GC-TEA analysis technique GC-TEA (Gas Chromatography – Thermal Energy Analyzer) analysis is an advanced analytical method used to detect and quantify nitrogen-containing compounds. This process combines gas chromatography (GC) with a thermal energy analyzer (TEA), offering enhanced sensitivity and specificity for nitrogen compounds. - **Gas chromatography (GC)**: Sample compounds are separated in a chromatographic column. - **Thermal Energy Analyzer (TEA)**: After separation, compounds pass through the TEA where they are pyrolyzed. Nitrogen-containing compounds produce nitrogen oxides, which react with ozone to form excited light-emitting species, detected by the TEA. ### Our nitrosamine analysis - [NDEA (CAS : 55-18-5)](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/laboratory-analysis-ndea.md) - [NDMA (CAS : 62-75-9)](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/laboratory-analysis-ndma.md) - [NEIPA (CAS : 16339-04-1)](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/laboratory-analysis-neipa.md) - [NDIPA (CAS : 601-77-4)](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/laboratory-analysis-ndipa.md) - [NMBA (CAS : 61445-55-4)](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/laboratory-analysis-nmba.md) - [NDBA (CAS : 924-16-3)](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/laboratory-analysis-ndba.md) - [NMPA (CAS : 614-00-6)](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/laboratory-analysis-nmpa.md) - [NDPA (CAS: 621-64-7)](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/laboratory-analysis-of-ndpa-2.md) - NMEA (10595-95-6) - MeNP (16339-07-4) - NMOR (59-89-2) - NPYR (930-55-2) - NPIP (621-64-7) - NMPEA (13256-11-6) - [NDELA (1116-54-7)](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/analysis-of-ndela-according-to-iso-10130.md) - NDPh/NDPhA (86-30-6) - NMPH (55557-03-4) - NEPhA (612-64-6) - NDINA (1207995-62-7) - [NDSRI](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/ndsri-nitrosamine-impurities-derived-from-the-active-substance-analysis-laboratory/)  ## FILAB can help you analyse your products for nitrosamines using GC-TEA ### Why choose FILAB for your GC-TEA analysis of nitrosamines ? In order to support manufacturers in the development and quality control of their products, in line with regulatory developments, the laboratory provides[ state-of-the-art analytical equipment](https://filab.fr/nos-moyens-techniques.md), enabling the determination of nitrosamines by GC-TEA and their precursors in trace form, in all types of matrices (pharmaceutical, cosmetics, polymer, water, food). In addition, FILAB has in-depth knowledge of pharmaceutical regulatory texts.  FILAB also has a COFRAC-validated method for the determination of certain nitrosamines by LC-MSMS within the framework of **[ISO 10993-18](https://filab.fr/en/our-services/our-expertise-services/laboratory-biocompatibility-testing/laboratory-material-chemical-characterization.md).** ### Our other technical resources for nitrosamine analysis [LC-MSMS](https://filab.fr/en/our-technical-resources/laboratory-analysis-uplc/laboratory-analysis-hplc-lcms.md) [GC-MS/MS](https://filab.fr/en/our-technical-resources/gc-msms-analysis-laboratory.md) [GC-MS](https://filab.fr/en/our-technical-resources/laboratory-analysis-gcms.md) [LC-UV](https://filab.fr/en/our-technical-resources/laboratory-analysis-uplc/hplc-uv-analysis-laboratory.md) ## see also [Determination of nitrosamines in pharmaceutical products](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/laboratory-analysis-pharmaceutical-nitrosamines.md) [Elemental impurity analysis (ICHQ3D context)](https://filab.fr/en/our-services/our-analysis-services/analysis-ich-q3d-context.md) [Cosmetics: ATNC method](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/nitrosamines-testing-atnc-method.md) [Development, validation and transfer of a nitrosamine determination method](https://filab.fr/en/our-services/rd/life-cycle-of-an-analytical-method-in-the-laboratory/analytical-development/) [Determination of nitrosamines in cosmetic products](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines/analysis-nitrosamines-cosmetics.md) Discover our case study ## Nitrosamines in IV bags: what does the FDA say and how can we protect ourselves? [Learn more](https://filab.fr/en/blog/2025/12/nitrosamines-in-infusion-bags-what-does-the-fda-say-and-how-can-you-protect-yourself.md) ## Our FAQ Why is it important to detect nitrosamines ? The detection of nitrosamines is crucial due to their carcinogenic potential. The presence of nitrosamines in products consumed or used by humans must be strictly controlled to guarantee health safety and regulatory compliance. How does GC-TEA analysis work for nitrosamines ? Sample preparation: The sample is prepared for injection into the gas chromatography instrument. Chromatographic separation: Sample compounds are separated in a chromatographic column. TEA detection: The separated compounds then pass through the thermal energy detector, where nitrogen-containing compounds, such as nitrosamines, are pyrolyzed. The nitrogen oxides formed react with ozone to produce a specific light emission, detected by TEA.