---
type: "WebPage"
title: "Laboratory OECD 105 solubility test"
description: "The OECD 105 solubility test is a standardized method used to determine the aqueous solubility of a chemical substance. This test is essential for assessing a substance’s behavior in the environment and in various industrial processes. A substance’s solubility in..."
resource: "https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-nanomaterial/laboratory-solubility-testing/"
tags: ["EN", "pll_617174f2b233d", "Clément BOENARD"]
timestamp: "2026-07-08T09:59:47Z"
published: "2021-10-22T06:51:21Z"
language: "en"
author: "Laure Durieux"
---

# Laboratory OECD 105 solubility test

The **OECD 105 solubility test** is a standardized method used to determine the **aqueous solubility** of a [chemical substance](https://filab.fr/en/our-services/our-analysis-services/chemical-analysis-laboratory/identification-of-a-chemical-substance-in-the-laboratory.md). This test is essential for assessing a substance’s behavior in the environment and in various industrial processes. A substance’s solubility in water represents its saturation concentration in water at a defined temperature.

## Would you like to carry out an OECD 105/OECD 105 solubility test

### OECD 105: measuring water solubility and REACH compliance

**Accurately determine the solubility of your substances and secure your regulatory files thanks to FILAB’s expertise, a leader in physicochemical characterization.**

Water solubility is one of the fundamental properties required for the registration of chemical substances under the **REACH** regulation. For nanometric materials, this test is the first critical filter: it determines whether your product must follow the complex pathway for “nanomaterials” or whether it can be treated as a conventional soluble substance.

### Principle of the OECD 105 solubility test

The test consists of determining the **maximum concentration** of a substance dissolved in water under equilibrium conditions, at controlled temperature. Two methods are recommended for carrying out this test:

 The shaking method (Flask method)
- Suitable for substances with solubility below **10^-2 g/L**.
- The substance is suspended in water and shaken until equilibrium is reached.
- After filtration or centrifugation, the concentration is measured using an appropriate analytical technique (HPLC, UV-Vis, GC, etc.).

 The column elution method (Column Elution method)
- Suitable for substances with solubility below **10^-2 g/L**.
- Water saturates the substance in a column, and the eluate is analyzed to determine the concentration in solution.

## FILAB laboratory carries out OECD 105 solubility tests

### Our technical resources for OECD 105 analysis

### Column elution method

for poorly soluble substances (<10 mg/L)

### Flask method

for more soluble substances (> 10 mg/L)

### ICP-AES / ICP-MS

for measuring metal ions with extreme sensitivity

### HPLC-UV / LC-MS

for complex organic molecules

### GC

for volatile or semi-volatile substances.

 [### TOC meter

for an overall measurement of the solubility of an organic mixture.](https://filab.fr/en/our-technical-resources/analysis-by-total-organic-carbon-meter-in-laboratory.md)
### Why carry out a solubility test according to OECD 105?

You may be required to carry out a solubility test in various contexts:

Regulatory safety tests

Toxicological assessment

Registration of a new chemical substance under REACH

Development of a new product

### Why choose FILAB?

- **Mutual Acceptance of Data (MAD):** in accordance with OECD principles, the data generated by our laboratory are recognized by all OECD member countries. This avoids duplicate testing and makes your global exports easier.
- **COFRAC ISO 17025 accreditation:** a guarantee of scientific rigor that is essential for the validity of your files with the ECHA.
- **Nanomaterials expertise:** our experts advise you on the most relevant testing strategy for your substance.
- **Research Tax Credit (CIR):** FILAB is an approved laboratory, enabling you to optimize your R&D and compliance budgets.

## Our other nanomaterials expertise services

The FILAB laboratory is ISO 17025 accredited by COFRAC for nanomaterials characterization!

 [Our accreditations](https://filab.fr/en/about-us/accreditations-en.md)
## our services

[Development and validation of analytical methods](https://filab.fr/en/our-services/our-expertise-services/analytical-development.md) specific to nanomaterials

[Training for your teams](https://filab.fr/en/our-services/rd/laboratory-analytical-chemistry-training.md) (technical aspects and regulatory requirements related to nanomaterials)

[Characterization of nanomaterials under REACH](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-nanomaterial/laboratory-reach-nanomaterial-regulation.md)

[Regulatory consulting for nanomaterials](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-nanomaterial/laboratory-nanomaterial-regulations.md) (EC Recommendation of 2011, EC Cosmetics Regulation No. 1223/2009, INCO Regulation No. 1169/2011, R-Nano (2012-232, 02/2012)...)

[Characterization of nanomaterials according to ISO 10993-22](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-nanomaterial/laboratoty-iso-10993-22-nanomaterial-characterization.md)

## OUR TECHNICAL RESOURCES

[FEG-SEM-EDX](https://filab.fr/nos-moyens-techniques/laboratoire-d-analysis-par-microscopie-electronique-a-balayage-meb-edx/): counting and determining the size and shape of nanoparticles

[Helium pycnometry](https://filab.fr/en/our-technical-resources/helium-pycnometry-analysis-laboratory.md): density measurement

[XRD](https://filab.fr/en/our-technical-resources/x-ray-crystallography-laboratory-xrd.md): structural analysis

[DLS](https://filab.fr/en/our-technical-resources/dynamic-light-scattering-dls-analysis.md): nano-emulsion measurement and suspension stability study by zeta potential titration.

[SP-ICP-MS](https://filab.fr/en/our-technical-resources/laboratory-analysis-icp-icp-ms-icp-aes.md): nanoparticle detection

[BET](https://filab.fr/en/our-technical-resources/laboratory-analysis-bet.md): specific surface area measurement

[Laser particle size analysis](https://filab.fr/en/our-technical-resources/laboratory-analysis-laser-granulometry.md): particle size distribution

[ICP-AES and ICP-MS](https://filab.fr/en/our-technical-resources/laboratory-analysis-icp-icp-ms-icp-aes.md): trace and chemical composition analysis on a nanomaterials-based product

## to go further

Determination of regulated substances: [heavy metals](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-heavy-metal.md), [phthalates](https://filab.fr/en/our-services/our-analysis-services/chemical-analysis-laboratory/analysis-and-determination-of-phthalates-in-the-laboratory.md), [nitrosamines](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-nitrosamines.md), bisphenol A, [residual solvents](https://filab.fr/nos-prestations/analyse/laboratoire-analysis-solvants-residuels-cov/)

[Chemical analysis according to REACH](https://filab.fr/nos-prestations/analyse/laboratoire-analysis-reach/)

[Development and validation of chemical analysis methods](https://filab.fr/en/our-services/our-expertise-services/analytical-development.md)

[Reverse engineering](https://filab.fr/en/our-services/our-expertise-services/laboratory-deformulation-analysis-reverse-engineering.md)

[Analysis of elemental impurities](https://filab.fr/en/our-services/our-analysis-services/analysis-ich-q3d-context.md)

[Analysis of elemental impurities](https://filab.fr/nos-prestations/analyse/laboratoire-analysis-reach/)

[Compliance with EC Recommendation 2022](https://filab.fr/nos-prestations/expertise/laboratoire-analyse-nanomateriaux/nanomateriaux-recommandation-ce-2022.md)

## Our FAQ

 What does OECD 105 say?
Test No. 105 is a guideline for the analysis of the solubility of chemicals according to specific tests. Indeed, OECD 105 aims to identify and define the potential hazards of new chemical substances, chemical preparations and chemical mixtures.

Thus, according to the OECD Guidelines for the Testing of Chemicals, Section 1, solubility determination methods are carried out on pure, non-volatile substances that are stable in water.

 Why choose FILAB for an OECD 105 solubility test?
At FILAB laboratory, we carry out solubility tests under conditions defined and validated with the client according to their needs and field of application.

Thanks to state-of-the-art analytical equipment (including 15 ICPs), we perform solubility tests on a wide range of raw materials, including nanometric-sized materials.

 How can i get a quote from FILAB?
To get a quote, you can contact our teams via our contact form, by phone or by email.
All you need to do is send us your requirements (type of material, analysis requested, any standard to be applied, urgency, number of samples, etc.). We will then send you a tailored technical and pricing proposal within 24-48 hours.

 What is the typical analysis turnaround time?
Lead times vary depending on the nature of the analysis and the complexity of the expert assessment project.
However, FILAB is committed to providing fast turnaround times adapted to your constraints and industrial urgencies.