---
type: "WebPage"
title: "Deformulation of an active ingredient in the laboratory"
description: "You want to make a deformulation of your active ingredient? What is an active ingredient? An active ingredient is a chemical substance present in the composition of a drug that gives it its therapeutic or preventive properties.There are several ways..."
resource: "https://filab.fr/en/our-services/our-expertise-services/laboratory-deformulation-analysis-reverse-engineering/deformulation-active-ingredient-laboratory/"
tags: ["EN", "pll_62821916126bd", "Anaïs DECAUX"]
timestamp: "2025-12-31T08:44:26Z"
published: "2022-06-15T14:19:32Z"
language: "en"
author: "bwa"
---

# Deformulation of an active ingredient in the laboratory

## You want to make a deformulation of your active ingredient?

### What is an active ingredient?

An active ingredient is a chemical substance present in the composition of a drug that gives it its therapeutic or preventive properties.

There are several ways to synthesize active ingredients on an industrial scale:

- They can be extracted from natural sources, an interesting technique especially when the active substances are relatively complex
- By chemical means, when the active ingredients are simple
- and finally, by genetic engineering by inserting a gene coding for a protein into a bacterium, for example.

### Why distort the active ingredient of your pharmaceutical products?

This process of deformulation is particularly used by manufacturers in order to :

- Develop a new formulation of the active ingredient
- Analyze two formulations of the active ingredient in a comparative way (double-sourcing or multi-surcing)
- Determine the exact composition of the active ingredient
- Analyze and identify an impurity in the active ingredient

## Our solutions: to accompany you in your project of deforming the active ingredient of a pharmaceutical product

Successful deformulation is the result of a good knowledge of the targeted application and the implementation of precise and tailor-made analytical methods.

With its state-of-the-art analytical facilities (a technical platform of more than 2,100 m2) and qualified and experienced staff, FILAB can assist you in your pharmaceutical deformulation projects, with tailor-made monitoring and expertise.

In order to support its customers in their active ingredient deformulation projects, FILAB has a range of diversified and sometimes very advanced techniques:

## our resources

[Gas chromatography](https://filab.fr/en/our-technical-resources/laboratory-analysis-gcms.md) coupled to mass spectrometry (GCMS)

Spectrometric analysis by [ICP-MS and ICP-AES](https://filab.fr/en/our-technical-resources/laboratory-analysis-icp-icp-ms-icp-aes.md)

[Nuclear magnetic resonance (NMR)](https://filab.fr/en/our-technical-resources/laboratory-analysis-nmr.md)

[Liquid chromatography coupled to mass spectrometry (LCMS)](https://filab.fr/en/our-technical-resources/laboratory-analysis-uplc.md)

Analysis by liquid chromatography using CLI

[X-ray Diffraction (XRD)](https://filab.fr/en/our-technical-resources/x-ray-crystallography-laboratory-xrd.md)