---
type: "WebPage"
title: "USP 662 compliance analysis for metal packaging"
description: "As an industrialist, you wish to perform USP 662 compliance analysis of your metal packaging Metal packaging used for pharmaceutical products must ensure the safety, stability, and regulatory compliance of the drug.USP 662 (Metal Packaging Systems and Their Materials of..."
resource: "https://filab.fr/en/our-services/our-expertise-services/laboratory-extractable-leachable-testing/usp-662-metal-packaging/"
tags: ["EN", "pll_690dcac358cd9", "Anaïs DECAUX"]
timestamp: "2025-12-31T08:32:21Z"
published: "2025-11-07T10:43:28Z"
language: "en"
author: "Laure Durieux"
---

# USP 662 compliance analysis for metal packaging

## As an industrialist, you wish to perform USP 662 compliance analysis of your metal packaging

**[Metal packaging](https://filab.fr/en/sectors-of-activity/health-pharmaceutical-cosmetics/packaging-analysis-laboratory-for-the-pharmaceutical-industry.md)**used for pharmaceutical products must ensure the **safety, stability, and regulatory compliance** of the drug.
**USP 662 (Metal Packaging Systems and Their Materials of Construction)** defines the tests required to verify that this packaging does not release undesirable substances and that it is compatible with the product.

### Our analytical services according to USP

Through our state-of-the-art [analytical resources](https://filab.fr/en/our-technical-resources.md) and our teams specializing in metallic materials and pharmaceutical analysis, we perform all the tests required by the USP 662 standard:

[Chemical characterization of your packaging materials](https://filab.fr/nos-prestations/analyse/laboratoire-caracterisation-des-materiaux.md)and their properties 

Analysis of [extractables and leachables](https://filab.fr/en/our-services/our-expertise-services/laboratory-extractable-leachable-testing.md)

Internal or external surface analysis

[Support in choosing your materials](https://filab.fr/en/our-services/rd/rd-support/support-from-a-laboratory-in-the-choice-of-your-raw-materials/)

[Physicochemical](https://filab.fr/en/our-services/our-analysis-services/chemical-analysis-laboratory/laboratory-analysis-physicochemical.md) tests (defined according to the type of medicinal product and the type of plastic)

[Melting](https://filab.fr/en/our-services/our-analysis-services/polymer-materials-analysis-laboratory/laboratory-material-characterization/measurement-of-the-melting-temperature-in-the-laboratory/) point or [glass transition](https://filab.fr/en/our-services/our-analysis-services/polymer-materials-analysis-laboratory/determining-the-glass-transition-temperature-in-the-laboratory.md) point

[Analysis of heavy metals](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-heavy-metal/heavy-metal-analysis-pharmaceutical-industry.md)

[Corrosion analysis](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-deposit-contamination/laboratory-expertise-and-analysis-of-corrosion.md)

[Container-content interaction](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-container-contents-interactions.md)

[Accelerated ageing study](https://filab.fr/nos-prestations/analyse/laboratoire-caracterisation-des-materiaux/filab-met-en-oeuvre-les-tests-de-vieillissement-accelere.md)

Analysis of an unknown particle and comparison with packaging or delivery material

Study of the device's physical properties: thickness, porosity, etc.

Analysis of hazardous substances

[Analysis of additives](https://filab.fr/en/our-services/our-analysis-services/polymer-materials-analysis-laboratory/polymer-additives.md) purity

[Migration test](https://filab.fr/en/our-services/our-analysis-services/polymer-materials-analysis-laboratory/plasticizer-migration-study.md)

[Stability testing](https://filab.fr/en/sectors-of-activity/health-pharmaceutical-cosmetics/stability-testing-medications-and-active-ingredients.md)

[Analytical validation](https://filab.fr/nos-prestations/expertise/cycle-vie-methode-analytique/laboratoire-validation-analytique/analyse-dosage.md)

[Coating analysis](https://filab.fr/en/our-services/our-analysis-services/laboratory-surface-characterization/laboratory-surface-coating-characterization.md): [passivation](https://filab.fr/en/our-services/our-analysis-services/laboratory-surface-characterization/laboratory-characterization-passivation.md), [varnish](https://filab.fr/en/our-services/our-analysis-services/polymer-materials-analysis-laboratory/laboratory-analysis-paint-varnish.md)...

## Our technical resources for the analysis of metal packaging according to USP 662

 [### ICP-MS , ICP AES/OES](https://filab.fr/en/our-technical-resources/laboratory-analysis-icp-icp-ms-icp-aes.md) [### CHNSO](https://filab.fr/en/our-technical-resources/chons-laboratory-analysis.md) [### SEM-EDX](https://filab.fr/en/our-technical-resources/laboratory-analysis-sem-scanning-electron-microscopy.md) [### IRTF

FTIR](https://filab.fr/en/our-technical-resources/laboratory-analysis-ftir-spectroscopy.md) [### HPLC-MS](https://filab.fr/en/our-technical-resources/laboratory-analysis-uplc.md) [### GC-MS](https://filab.fr/en/our-technical-resources/laboratory-analysis-gcms.md) [### Pycnometry](https://filab.fr/en/our-technical-resources/helium-pycnometry-analysis-laboratory.md)
## The FILAB laboratory assists you with your analysIs according to USP 662

### Regulatory context: the requirement of USP 662

**USP 662** is part of the **United States Pharmacopeia (USP)** guidelines, alongside other standards such as USP 1660, ICH Q3D, and USP chapters 232 and 233 related to trace metals.

It applies to **metal packaging systems used in the storage**, transport, or manufacturing of pharmaceutical products.
The tests aim to:

- Identify metals that may interact with the drug,
- Quantify the release of metal ions,
- Evaluate corrosion and chemical compatibility,
- Ensure patient safety and drug stability.

### Why choose FILAB

- **Dual expertise** in metallic materials and pharmaceutical regulations
- [**ISO 17025 accredited laboratory**](https://filab.fr/en/about-us/accreditations-en/laboratory-analysis-iso-17025.md)
- **Responsiveness and personalized support**
- **Complete analytical platform** on a single site
- **Interpretation and consulting**

### Our analysis according to the USP

[Analysis according to USP 661-1 and USP 661-2](https://filab.fr/en/our-services/our-expertise-services/laboratory-extractable-leachable-testing/usp-661-laboratory-analysis.md)

[Analysis according to USP 467](https://filab.fr/en/our-services/our-analysis-services/voc-analysis-laboratory/usp-467-laboratory-analysis.md)

[Leaching analysis according to USP 1663 and USP 1664](https://filab.fr/en/our-services/our-expertise-services/laboratory-extractable-leachable-testing/leaching-analysis-laboratory-according-to-usp-1663-and-usp-1664.md)

[Training on particle counting according to USP 788](https://filab.fr/en/our-services/rd/laboratory-analytical-chemistry-training/training-particle-counting.md)

[Analysis according to USP 788](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-particulate-contaminant/particle-counting-laboratory-according-to-usp-788.md)

[Method validation according to USP 1225](https://filab.fr/en/our-services/our-expertise-services/life-cycle-of-an-analytical-method-in-the-laboratory/laboratory-analytical-method-validation/method-validation-according-to-usp-1225.md) and [USP 1226](https://filab.fr/en/our-services/our-expertise-services/life-cycle-of-an-analytical-method-in-the-laboratory/laboratory-analytical-method-validation/method-verification-usp-1226.md)

[Analysis according to USP 665](https://filab.fr/en/sectors-of-activity/analysis-industry-pharmaceuticals/usp-665-analysis.md)

[Elemental impurity analysis according to USP 233](https://filab.fr/en/our-services/our-analysis-services/analysis-usp-233-laboratory.md)

## FAQ

 Who are our USP <662> analyses intended for?
Our services target **players in the pharmaceutical sector**:

- Pharmaceutical laboratories and drug manufacturers
- Producers of metal packaging (caps, stoppers, containers, tanks, reactors, etc.)
- Quality, R&D, Regulatory Affairs, and Industrialization services

 What is the USP <662> standard?
USP 662 is a chapter of the United States Pharmacopeia that defines the requirements for **metallic packaging systems used in the pharmaceutical industry**.

It aims to ensure that metallic materials do not release undesirable substances and that they are chemically compatible with the pharmaceutical product they contain or transport.

 What types of packaging are covered by USP 662?
USP 662 applies to all **metallic systems in direct or indirect** contact with the drug, such as:

- stainless steel or aluminum containers,
- metal caps and closures,
- reactors, tanks, pipelines, and pharmaceutical production equipment.
  These components must demonstrate their inertness and safety with respect to the product.

 What are the main analysis carried out for USP <662>?
The tests include:

- the**elemental composition** of the material (ICP-MS, ICP-OES, SEM-EDS),
- **metal ion extraction and release tests**,
- **corrosion and chemical compatibility studies**, pH, conductivity, and total organic carbon (TOC) measurements.

These analysis allow for the evaluation of the material's behavior in contact with the drug.

 What is the difference between USP <661> and USP <662>?
- **USP 661 covers plastic and elastomeric packaging**.
- **USP 662 applies specifically to metal packaging and packaging systems**.
  Both chapters share the same objective: to ensure container-content compatibility and prevent any contamination of the pharmaceutical product.

 Is USP 662 mandatory?
Yes, for **companies that market their pharmaceutical products** in the United States, compliance with USP 662 is one of the requirements of the United States Pharmacopeia.
Even in other markets, it is often used as an international standard to demonstrate the quality and safety of metal packaging.