---
type: "WebPage"
title: "Intact mass analysis laboratory"
description: "As a biopharmaceutical manufacturer, you want to perform intact mass analysis of your monoclonal antibodies What is the intact mass of monoclonal antibodies? Intact mass analysis of monoclonal antibodies (mAbs) makes it possible to accurately determine the molecular weight of..."
resource: "https://filab.fr/en/sectors-of-activity/biopharmaceutical/intact-mass-analysis-laboratory/"
tags: ["EN", "pll_67ade50191790", "Anaïs DECAUX"]
timestamp: "2026-05-29T07:54:07Z"
published: "2025-02-13T12:44:20Z"
language: "en"
author: "Laure Durieux"
---

# Intact mass analysis laboratory

## As a biopharmaceutical manufacturer, you want to perform intact mass analysis of your monoclonal antibodies

### What is the intact mass of monoclonal antibodies?

Intact mass analysis of [monoclonal antibodies (mAbs)](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization/analysis-characterization-monoclonal-antibodies-mabs.md) makes it possible to accurately determine the molecular weight of the different proteoforms, thereby ensuring their characterization and quality control.

### Why analyze the intact mass of monoclonal antibodies?

Les [anticorps monoclonaux (mAbs)](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization/analysis-characterization-monoclonal-antibodies-mabs.md) sont des biomolécules clés dans le développement de thérapies innovantes. Leur caractérisation précise est essentielle pour assurer leur efficacité et leur conformité réglementaire. L’analyse de masse intacte permet de :

**Verify the molecular integrity** of monoclonal antibodies

**Control the purity and homogeneity** of production batches

**Detect mass variations** related to post-translational modifications ([glycosylation](https://filab.fr/en/sectors-of-activity/biopharmaceutical/glycosylation-analysis.md), oxidation, deamidation…)

**Optimize the development and manufacturing** of mAbs

## FILAB supports biopharmaceutical manufacturers in the intact mass analysis of monoclonal antibodies

### Why choose FILAB for intact mass analysis?

FILAB, an analytical expertise laboratory, offers comprehensive services for the intact mass analysis of monoclonal antibodies.

Our experts support you in interpreting the results and optimizing your processes. Thanks to our expertise in **analysis, expertise and R&D**, we help you ensure the quality and compliance of your monoclonal antibodies.

## our technical capabilities

[HPLC](https://filab.fr/nos-moyens-techniques/laboratoire-analysis-chromatographie-liquide-hplc/)

[IRTF](https://filab.fr/en/our-technical-resources/laboratory-analysis-ftir-spectroscopy.md)

[AAV characterization by GPC/SEC according to the MAM method](https://filab.fr/en/sectors-of-activity/biopharmaceutical/characterization-aavs-mam.md)

[LC-MS](https://filab.fr/en/our-technical-resources/altis-lc-msms-analysis.md)

[NMR](https://filab.fr/en/our-technical-resources/laboratory-analysis-nmr.md)

## Our services dedicated to the analysis of biopharmaceutical products

Identity and structure of biomolecules: primary sequence ([peptide mapping](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization/peptide-analysis-biopharmaceutical-services.md)), [de novo sequencing](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization/de-novo-protein-sequencing.md)

Secondary and tertiary structure analysis: thermal stability, [circular dichroism (CD)](https://filab.fr/en/sectors-of-activity/biopharmaceutical/measurement-circular-dichroism-cd.md), UV/visible profiles and analysis by [FTIR](https://filab.fr/en/our-technical-resources/laboratory-analysis-ftir-spectroscopy.md)

[Monosaccharide composition analysis](https://filab.fr/en/sectors-of-activity/biopharmaceutical/monosaccharide-structure-analysis-laboratory.md)

Analysis and localization of [disulfide bridges](https://filab.fr/en/sectors-of-activity/biopharmaceutical/disulfide-bridge-analysis.md)

[Glycosylation analysis](https://filab.fr/en/sectors-of-activity/biopharmaceutical/glycosylation-analysis.md)

[Residual host cell DNA analysis](https://filab.fr/en.md)

  ![](https://filab.fr/wp-content/uploads/2024/10/nucleotide-2.jpg.png)