--- type: "WebPage" title: "Laboratory proteomic analysis" description: "Your need: ensure the quality and compliance of your products by mastering their proteomic composition Proteomic analysis Proteomic analysis is a cutting-edge method used to identify, characterize and quantify the proteins present in complex biological samples. These studies make it..." resource: "https://filab.fr/en/sectors-of-activity/biopharmaceutical/laboratory-proteomic-analysis/" tags: ["EN", "pll_6751be29c76c9", "Anaïs DECAUX"] timestamp: "2026-08-04T13:32:06Z" published: "2024-12-05T15:46:25Z" language: "en" author: "Laure Durieux" --- # Laboratory proteomic analysis ## Your need: ensure the quality and compliance of your products by mastering their proteomic composition ## Proteomic analysis Proteomic analysis is a cutting-edge method used to **identify, characterize and quantify the proteins present in complex biological samples**. These studies make it possible to explore the **proteome**, that is, the full set of proteins expressed in a cell, tissue or organism at a given time. ### Protein composition, structure and quantification Proteomic analysis provides data on: **Protein composition** : identification of proteins of interest or undesirable proteins (e.g. contaminants or allergens). **Protein structure** : analysis of post-translational modifications, conformations or protein-protein interactions. **Protein quantification** : monitoring the concentration of active proteins or biomarkers in a product or process ### Proteomic analysis for biopharmaceuticals Proteomic analysis is essential to ensure the quality, safety, and efficacy of **biotherapies such as recombinant proteins, monoclonal antibodies, and vaccines**.  The [recombinant proteins](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization.md), used in many treatments, require precise characterization to verify their structure and detect any post-translational modifications. The [monoclonal antibodies](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization/analysis-characterization-monoclonal-antibodies-mabs.md), essential in targeted therapies, require in-depth analysis to ensure their purity, stability, and ability to interact properly with biological targets. Finally, vaccines, whether protein-based or nucleic acid-based, require proteomic validation to guarantee their efficacy and eliminate risks related to contaminants or structural variations.  It makes it possible to characterize [post-translational modifications](https://filab.fr/services/laboratoire-danalyse-des-modifications-post-traductionnelles-des-proteines.md), ensure protein integrity, and meet regulatory requirements in [biopharmaceutical](https://filab.fr/en/sectors-of-activity/biopharmaceutical.md). #### Proteomic analysis to control biotherapies For [biosimilars](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization/analysis-characterization-biosimilars.md), proteomic analysis helps ensure equivalence with originator products. For plasma-derived products, this analysis ensures the identification and quantification of critical proteins, while optimizing manufacturing processes. Proteomic analysis therefore provides answers to secure and optimize the development and production of these biotherapies. ## The FILAB laboratory carries out your proteomic analysis for safe and high-performance biotherapies The FILAB laboratory has the experience and the [analytical equipment](https://filab.fr/en/our-technical-resources.md) needed to support biopharmaceutical companies with proteomic analysis through **tailor-made support**. ## Our services for proteins [Recombinant protein analysis](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization.md) [ICH Q6B training](https://filab.fr/en/our-services/rd/laboratory-analytical-chemistry-training/ich-q6b-training.md) [De novo sequencing](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization/de-novo-protein-sequencing.md) [Amino acid analysis](https://filab.fr/en/our-services/our-analysis-services/chemical-analysis-laboratory/analysis-amino-acids/study-amino-acids.md) [Glycoprotein characterization analysis](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization/analysis-characterization-glycoproteins.md) Peptide analysis and characterization [(peptide mapping)](https://filab.fr/en/sectors-of-activity/biopharmaceutical/biotherapeutic-recombinant-protein-characterization/peptide-analysis-biopharmaceutical-services.md) [Proteomic analysis](https://filab.fr/en/sectors-of-activity/biopharmaceutical/laboratory-proteomic-analysis.md) [Host Cell Protein (HCP)](https://filab.fr/en/sectors-of-activity/biopharmaceutical/host-cell-protein-hcp-testing-analysis-laboratory.md) ## Our technical resources [### MALDI-TOF](https://filab.fr/en/our-technical-resources/maldi-tof-laboratory-analysis.md) [### HPLC-MS/MS](https://filab.fr/en/our-technical-resources/laboratory-analysis-uplc/laboratory-analysis-hplc-lcms.md) [### LC-Orbitrap](https://filab.fr/en/our-technical-resources/lc-orbitrap-analysis.md) [### LC-QTOF](https://filab.fr/en/our-technical-resources/laboratory-for-lc-qtof-analysis.md) ## FAQ Why is proteomic analysis essential for biotherapies? Proteomic analysis is important for ensuring the quality, safety, and efficacy of biotherapies. It makes it possible to characterize therapeutic proteins (e.g., recombinant proteins, monoclonal antibodies) by detecting post-translational modifications, structural variations, and any degradation, in order to meet strict regulatory requirements and ensure product stability. How does proteomic analysis help manage biosimilars? For biosimilars, proteomic analysis is essential to demonstrate their equivalence with reference products. It makes it possible to compare protein profiles in detail, identify any differences, and ensure that biosimilars meet the same quality, efficacy, and safety standards as the original product, in accordance with regulations. What are the applications of proteomic analysis in quality control? In quality control, proteomic analysis is used to verify batch purity, identify degraded or modified proteins, and detect any contamination. These analysis ensure that each produced batch meets the defined specifications and helps avoid the risk of product rejection or recalls. What are the benefits of proteomic analysis for production processes? Proteomic analysis helps optimize bioprocesses by identifying critical protein-related steps (e.g., aggregation, degradation). This contributes to improving yield, reducing production costs, and avoiding interruptions caused by quality issues. It is also essential for validating changes made to manufacturing processes or raw materials. Why carry out proteomic analysis in cosmetics? For the cosmetics industry, proteomic analysis plays a key role in identifying and validating biological actives, particularly bioactive peptides used in anti-aging or moisturizing formulations. Manufacturers need precise control to ensure that the biological mechanisms targeted by their products are effective, while also guaranteeing the absence of contaminants or allergens in the formulations. Why perform proteomic analysis in the laboratory? Proteomic analysis enables companies in the biopharmaceutical sectors to address: - **Quality control and compliance** : Ensuring the integrity, stability, and safety of therapeutic proteins while meeting strict regulatory requirements. - **Bioprocess optimization** : Characterizing key proteins to refine formulations and control critical stages of manufacturing processes. - **Contaminant detection** : Identifying exogenous or trace proteins that could compromise the purity or efficacy of biotherapies.