--- type: "WebPage" title: "Laboratory analysis and determination of HEMA and OTP in nail varnishes" description: "As a cosmetics manufacturer, you would like to carry out an analysis and dosage of HEMA and OTP (CAS 75980-60-8) in your varnishes Who are HEMA and OTP? HEMA (Hydroxyethyl Methacrylate) is a methacrylate monomer widely used in cosmetic products,..." resource: "https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics/determination-hema-otp-varnishes/" tags: ["EN", "pll_67d15912210b0", "Anaïs DECAUX"] timestamp: "2025-12-31T08:32:30Z" published: "2025-03-12T10:41:37Z" language: "en" author: "Laure Durieux" --- # Laboratory analysis and determination of HEMA and OTP in nail varnishes ## As a cosmetics manufacturer, you would like to carry out an analysis and dosage of HEMA and OTP (CAS 75980-60-8) in your varnishes ### Who are HEMA and OTP? HEMA (Hydroxyethyl Methacrylate) is a **methacrylate** [monomer](https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics/analysis-of-residual-monomers-for-the-cosmetics-industry.md) widely used in cosmetic products, particularly in **semi-permanent nail polishes and UV gels**. It improves product adhesion and flexibility, while ensuring proper polymerization under UV lamps. It presents allergenic risks. As for OTP (CAS 75980-60-8) (**diphenyl trimethylbenzoyl phosphine oxide**), it is a photoinitiator widely used in nail formulations. It is mainly found in gels and polishes cured under UV or LED lamps. Its main function is to trigger the polymerization reaction, which ensures fast and efficient curing. Its use improves the strength and durability of products such as sculpting gels, base coats, top coats, and even semi-permanent nail polishes. ### Existing regulations regarding HEMA and OTP in varnishes ⚠️Since **January 5, 2024**, OTP has been officially classified as a **CMR 1B substance**, indicating a potential risk. This classification will become legally binding in **September 2025**, leading to its **gradual removal from cosmetic formulations**, particularly nail products. The regulations governing methacrylates in cosmetics, particularly HEMA, are based on several directives and regulations: - **Regulation (EC) No. 1223/2009** - **REACH ** ## our services [Analysis and determination of 1.4-dioxane in cosmetic](https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics/determination-of-14-dioxane-in-cosmetic-products.md) [Determination of active ingredients](https://filab.fr/en/sectors-of-activity/health-pharmaceutical-cosmetics/laboratory-analysis-active-ingredients.md): organic and mineral sunscreens, vitamins... [Analytical validation according to ISO 12787](https://filab.fr/en/our-services/our-expertise-services/laboratory-analytical-method-validation.md)   [Reverse Engineering](https://filab.fr/en/our-services/our-expertise-services/laboratory-deformulation-analysis-reverse-engineering/reverse-engineering-in-laboratory.md) [Laboratory audit](https://filab.fr/en/our-services/rd/laboratory-audit.md) and [team training](https://filab.fr/en/our-services/rd/laboratory-analytical-chemistry-training.md)   Analysis of undesirable substances on raw materials and finished products: [heavy metals](https://filab.fr/en/our-services/our-analysis-services/laboratory-analysis-heavy-metal.md), [residual solvents](https://filab.fr/en/our-services/our-analysis-services/voc-analysis-laboratory.md), phthalates, [bisphenol A](https://filab.fr/en/our-services/our-analysis-services/chemical-analysis-laboratory/laboratory-determination-contents-bisphenol-a.md)... Determination of preservatives ([phenoxyethanol](https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics/laboratory-analysis-phenoxyethanol.md), [parabens](https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics/parabens-analysis-laboratory.md), chlorphenesin...) [Expertise on non-conformities](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-failures.md): particles, deposits, unknown peaks, damage to materials, etc. Compatibility studies ([container/content interaction](https://filab.fr/en/our-services/our-expertise-services/laboratory-analysis-container-contents-interactions.md), [extractables and leachables](https://filab.fr/en/our-services/our-expertise-services/laboratory-extractable-leachable-testing.md)) ## The FILAB laboratory can assist you in the analysis and determination of HEMA and OTP in varnishes ### Why choose FILAB for the determination of HEMA and OTP in varnishes? The FILAB laboratory has developed extensive expertise in chemical analysis for the [cosmetics industry](https://filab.fr/en/sectors-of-activity/laboratory-analysis-cosmetics.md). The FILAB laboratory has state-of-the-art [analytical equipment](https://filab.fr/en/our-technical-resources.md) covering 5,200m2 and high-level human resources to offer its customers services that meet their compliance criteria for the analysis and determination of HEMA and OTP in varnishes. ## our technical resources [MS](https://filab.fr/nos-moyens-techniques/laboratoire-analyse-spectrometrie-de-masse.md) [HS-GC/MS](https://filab.fr/en/our-technical-resources/laboratory-analysis-gcms.md) [ICP-MS](https://filab.fr/en/our-technical-resources/icp-ms-analysis-laboratory.md) [FTIR](https://filab.fr/en/our-technical-resources/laboratory-analysis-ftir-spectroscopy.md) [MALDI-TOF](https://filab.fr/en/our-technical-resources/maldi-tof-laboratory-analysis.md) [LC-QTOF-MS](https://filab.fr/en/our-technical-resources/laboratory-for-lc-qtof-analysis.md) [HPLC-MS et HPLC-MS/MS](https://filab.fr/en/our-technical-resources/laboratory-analysis-uplc/laboratory-analysis-hplc-lcms.md) [TGA](https://filab.fr/en/our-technical-resources/tga-tga-ftir-and-tga-ms-analysis-at-filab-laboratory.md) ### Why analyse HEMA and OTP in your varnishes? HEMA - OTP ## Varnishes analysis Regulatory conformity Compliance with REACH requirements and European cosmetics regulations. Consumer safety Prevention of the risks of skin sensitisation and allergies. Optimisation de vos formulations Precise adjustment of concentrations to improve product resistance and safety. Quality control Identification of impurities and residual monomers impacting the performance of your varnishes.