Measurement of hyaluronic acid cross-linking rate in laboratory

The cross-linking process aims to modify the physical and chemical properties of hyaluronic acid, notably to improve its stability, viscosity and shelf life in various cosmetic and medical applications.

Hyaluronic acid cross-linking rate analysis can be performed for several reasons:

• Quality control : an optimum cross-linking rate guarantees the performance of products containing hyaluronic acid (wrinkle-filling gel, orthopedic treatments, etc.).
• Mechanical properties : the degree of cross-linking influences the rigidity and durability of hyaluronic acid gel. The more it is cross-linked, the firmer the material.
• Effect and durability : in the field of injectable devices, a higher degree of cross-linking can extend the product’s duration of action, but can also reduce its elasticity.