GPC (or SEC) analysis in a laboratory

Your needs : to characterize the size of your molecules using GPC or SEC

What do we mean by GPC/SEC?

Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a characterization technique used to determine the average molecular mass and distribution of molecular masses in a given sample. The dissolved sample is injected in a mobile phase (the eluent) into a column with controlled porosity (called the stationary phase).

By using this type of chromatography with a series of detectors (IR, UV, RALS light diffusion, Viscometer), the GPC/SEC technique allows for the exact mass and size of molecules to be determined as well as the intrinsic viscosity of polymer structures to be measured.

How is GPC/SEC used ?

GPC/SEC is an analytical technique used to characterize a wide variety of polymers or other macromolecules found in mixtures.

Used in quality control processes, when optimizing a procedure (ex. polymerization kinetics) or as part of an expertise (detection of pollutants or of contaminants…), this technique can meet the requirements of many industrialists in various fields : pharmaceuticals, plastics, chemistry, automobiles, foodstuffs, paints, lubricants, adhesives…

Our solution : to characterize the structure of your macromolecules using GPC/SEC

Our services

From analysis to R&D, FILAB laboratory provides multidisciplinary expertise to fulfil different requests surrounding the GPC/SEC technique :

  • Inspection of the average molecular mass and distribution of masses in polymer-based materials and substances (Mn, Mw, Mp ?, dispersity index). The NF T 51-505 standard and the ISO 13885 set cover this service.  

  • Structural characterization, namely branching analysis of macromolecular chains

  • Optimization of manufacturing procedures in order to improve synthesis, application and curing conditions   

  • Defect expertise of thermoplastic parts linked to degradations of the polymeric fraction (shearing of the material leading to chain scission)

  • Deformulation/Reverse engineering of polymers to understand their physicochemical properties using techniques such as FTIR, TGA, GC-MS, Py-GC-MS, LC-MS…     

  • Protein and polysaccharide characterization (sugars).

For this type of service, FILAB laboratory uses cutting edge analytical techniques such as Gel Permeation Chromatography (GPC/SEC) as well as Gas Chromatography coupled to a Mass Spectrometer after undergoing pyrolysis (Py-GCMS), Liquid Chromatography (LC-MSMS, HPLC…) followed up with other characterization techniques or even chemical analysis techniques (ICP-AES, ICP-MS, IC…).


As an independent laboratory, with a team made up of experienced doctors and engineers, FILAB guarantees the reliability of its results, ensures a quick turnaround for requests and provides tailored support for its clients.

Thomas ROUSSEAU Scientific and Technical Director
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