High-resolution mass spectrometry (HRMS) analysis in the laboratory - orbitrap Exploris 120 and Exploris 240
Do you need high-resolution mass spectrometry analysis in the laboratory?
Are you looking for a laboratory specializing in HRMS analysis?
High-resolution mass spectrometry (HRMS – High Resolution Mass Spectrometry) makes it possible to identify and characterize chemical compounds with very high precision thanks to the measurement of their exact mass.
Unlike conventional mass spectrometers, HRMS technologies make it possible to differentiate ions with very similar masses and to obtain detailed information on the molecular composition of the substances analyzed.
This technology is particularly suited for:
- identifying unknown compounds;
- characterizing complex molecules;
- detecting trace-level compounds;
- targeted and untargeted analysis;
- screening thousands of compounds in a single acquisition.
Orbitrap technology: high resolution for molecular characterization by FILAB
FILAB has an analytical platform that includes two high-resolution mass spectrometers: Orbitrap Thermo Scientific™ Exploris™ 120 and Exploris™ 240.
These instruments provide access to advanced analytical performance:
HRMS services at FILAB
High-resolution exact mass measurement (HRMS)
Identification and characterization of unknown compounds
Detection of trace-level molecules
Molecular formula determination
Targeted and non-targeted analysis (suspect screening / untargeted analysis)
Multi-compound screening in a single analysis
Our HRMS techniques
LC-orbitrap exploris™ 240
resolution up to 240,000 FWHM at m/z 200
LC-orbitrap exploris™ 120
resolution up to 120,000 FWHM at m/z 200
HRMS applications
The Orbitrap Exploris 120 and 240 enable FILAB to offer advanced approaches for the characterization of biomolecules and complex matrices.
- Proteomic analysis
- Lipidomic analysis
- Metabolomic analysis
- Glycomic analysis and biopolymer characterization
FILAB, an expert laboratory in high-resolution mass spectrometry
Thanks to its expertise in analytical chemistry, state-of-the-art analytical equipment, and specialized teams, FILAB supports industrial companies across many sectors (pharmaceutical, biopharmaceutical, medical devices, cosmetics, chemistry, materials, etc.) in their molecular characterization projects.
Our experts support you from defining the analytical strategy through to interpreting the results, in order to address your challenges
Our FAQ
To get a quote, you can contact our teams via our contact form, by phone or by email.
Simply send us your requirements (material type, desired analysis, any applicable standard, urgency, number of samples, etc.). We will then send you a personalized technical and pricing proposal within 24-48 hours.
Lead times vary depending on the nature of the analysis and the complexity of the expertise project.
However, FILAB is committed to providing fast turnaround times tailored to your constraints and industrial urgencies.
First of all, high-resolution mass spectrometers (high-resolution mass spectrometer, HRMS) with analyzers capable of accessing the exact mass such as the time-of-flight mass spectrometer (time of flight, TOF) or Orbitrap are used to quantify organic contaminants. The performance of analyzers is compared by their resolving power, which is defined by the ability to provide signals that can be distinguished for two peaks with nearby masses.
The ability to distinguish ions of different elemental composition with very close molecular masses is therefore determined by resolving power. As a result, high resolving powers are necessary to distinguish peaks with very close masses. A mass spectrometer is considered high resolution if its resolving power RP > 10,000 (FWHM at m/z 200). While the most efficient mass spectrometers are capable of achieving a resolving power of around 1,000 (FWHM at m/z 200), a TOF can reach a resolving power of 60,000 (FWHM at m/z 200) and an instrument equipped with an Orbitrap analyzer can achieve a resolving power of up to 600,000 (FWHM at m/z 200).
Thus, HRMS enables precise measurement of molecular masses or monoisotopic masses.
High-resolution mass spectrometry (HRMS) makes it possible to characterize biomolecules and study molecular profiles with great precision.
It is notably used for proteomics, peptide mapping, the characterization of therapeutic proteins, metabolomics, lipidomics, and the study of post-translational modifications.
A targeted HRMS analysis searches for and quantifies precisely defined compounds selected in advance. An untargeted approach, by contrast, makes it possible to broadly explore a sample in order to identify known or unknown compounds, potential biomarkers, or differences between batches.
Both instruments are based on Orbitrap technology and enable high-resolution mass spectrometry analysis with exact mass measurement.
The Orbitrap Exploris™ 240 offers higher resolution (up to 240,000 FWHM at m/z 200) and advanced sensitivity and characterization performance, particularly suited to complex analysis requiring high precision, such as proteomics, peptide mapping, or the identification of trace-level compounds.
The Orbitrap Exploris™ 120 also delivers high performance (up to 120,000 FWHM at m/z 200) and is a suitable solution for targeted and untargeted analysis requiring excellent mass accuracy.
The choice of instrument depends on the analytical challenge, the nature of the matrix, and the level of characterization required.
