LC MS and HPLC MS analysis in the laboratory
Your needs: analyze impurities in your products using HPLC-MS or LC-MS, LC-MSMS techniques
In the pharmaceutical, cosmetic, and chemical sectors, the detection and identification of trace compounds helps ensure product compliance, safety, and performance.
Thanks to LC MS or HPLC MS analysis, liquid chromatography coupled with mass spectrometry, our laboratory provides an analytical solution tailored to complex matrices and the strictest regulatory requirements.
What is HPLC MS?
HPLC-MS: high-performance liquid chromatography (HPLC) coupled with Mass Spectrometry (MS) makes it possible to identify and quantify non-volatile organic substances in various matrices.
It is a particularly useful technique for analyzing cosmetic products and the pharmaceutical industry in the laboratory, although it can be applied across all industries.
What is LC MS analysis?
LC-MS, or "Liquid Chromatography-Mass Spectrometry," meaning "liquid chromatography coupled with mass spectrometry", is a powerful analytical technique that combines the separation capabilities of liquid chromatography (LC) with the chemical analysis capabilities of mass spectrometry (MS).
Liquid chromatography (LC) separates the different components of a mixture. In LC, the sample is dissolved in a solvent and passed through a column containing a stationary phase. The different compounds in the sample interact differently with this material and move at different speeds, allowing them to be separated.
The mass spectrometry (MS): after separation by LC, the compounds are analyzed using this technique, which makes it possible to identify compounds by measuring the mass-to-charge ratio of their ions. The ions are separated according to their mass and charge. The mass spectrometer then produces a spectrum that can be used to determine the molecular mass of the compounds and identify their chemical structure.
Impurity analysis by LC MS or HPLC MS
Impurity analysis by LC-MS (Liquid Chromatography-Mass Spectrometry) or HPLC-MS (High-Performance Liquid Chromatography-Mass Spectrometry) is a technique used in many fields, particularly in the pharmaceutical industry.
Indeed, the combination of LC and MS enables specific analysis of complex mixtures. These methods are used to detect, identify, and quantify impurities or contaminants present in a sample.
Our solutions: liquid chromatography analysis (LC and HPLC) coupled with an MS or MS/MS detector
For more than 30 years, our FILAB laboratory has had the experience and dedicated analytical equipment to support companies with LCMS or HPLC MS analysis for raw material or finished product control through tailor-made support.
LC-MS or HPLC-MS: state-of-the-art equipment
Liquid chromatography (HPLC) coupled with a mass detector (MS) or mass-mass (MS-MS) makes it possible to determine the purity of raw materials or compounds in a sample.
LC MS analysis in the laboratory enables precise identification and quantification of compounds in complex samples. From the pharmaceutical sector to the chemical industry, our state-of-the-art LC-MS equipment is a solution of choice for detecting impurities and contaminants and characterizing new compounds. By choosing our laboratory for your LC-MS analysis needs, you benefit from cutting-edge technology and expertise in impurity expertise.
The benefits of LC MS or HPLC MS analysis
LCMS or HPLCMS analysis is an analysis that uses chromatography coupled with spectrometry.
Our services by LC MS or HPLC MS
LC MS / HPLC MS
Why use an LC-MS analysis laboratory?
Liquid chromatography coupled with mass spectrometry (LCMS) is a cutting-edge technique used to identify, quantify, and characterize organic or organometallic compounds, even at trace levels (ng/mL or lower).
It is essential when it comes to analyzing complex matrices or validating the compliance of products and materials in demanding industrial environments.
FAQ
Liquid chromatography-mass spectrometry analysis (LC-MS analysis) is a powerful analytical technique used to identify and quantify different compounds in complex samples. By separating and identifying the components of a sample, LC-MS analysis can provide detailed information about a sample’s composition, such as its identity, concentration, structure, and other characteristics. LC-MS analysis is used in sectors ranging from drug development to environmental monitoring. The method involves separating the components of a sample by liquid chromatography before analyzing them by mass spectrometry to identify them. Data obtained from an LC-MS analysis are often used to verify the purity or quality of compounds or to generate quantitative data for comparing samples. LC-MS analysis can be used to measure small amounts of substances such as drugs, toxins, hormones, and metabolites in biological samples. It is also used to look for contaminants in food and beverages, detect traces of toxic chemicals in the environment, and analyze the content of pharmaceutical products.
In addition to providing important analytical data, LC-MS analysis is increasingly used for diagnostic purposes, particularly to detect metabolic disorders or identify biomarkers associated with certain diseases. Its use for diagnostic purposes could revolutionize healthcare by providing clinicians with powerful tools for early disease detection and treatment. By providing detailed information on a sample’s composition, LC-MS analysis can prove invaluable for research and development efforts, helping researchers identify new compounds or better understand existing ones.
The main difference between LC-MS analysis and MS/MS analysis is that LC-MS involves separating compounds by liquid chromatography before they are analyzed by mass spectrometry, which is not the case with MS/MS. In LC-MS, the components of a sample pass through a stationary phase (such as a column) to separate them before being analyzed by mass spectrometry. By contrast, in MS/MS analysis, the compound goes directly into the mass spectrometer without prior separation. This results in faster analysis and greater sensitivity compared with LC-MS. However, because it involves no preliminary separation step, MS/MS analysis cannot provide detailed information about the sample’s composition or structure. It is mainly used for qualitative analysis.
At Filab, we offer state-of-the-art LC-MS and MS/MS analysis services in our laboratory to meet our clients’ needs. Our experienced team is committed to providing you with accurate and reliable results as quickly as possible. Our LC-MS analysis laboratory is at your disposal for any request.
The main difference between LC-MS and HPLC-MS lies in the type of liquid chromatography used.
In HPLC, separation resolution and efficiency are generally higher than with traditional LC methods. This is due to the use of narrower columns, smaller stationary-phase particles, and higher operating pressures in HPLC. HPLC-MS is often preferred in situations where high sensitivity and high accuracy are required, such as in trace analysis of contaminants.
