Deformation of an active ingredient in the laboratory

You want to make a deformation of your active ingredient?

What is an active ingredient?

An active ingredient is a chemical substance present in the composition of a drug that gives it its therapeutic or preventive properties.

There are several ways to synthesize active ingredients on an industrial scale:

  • They can be extracted from natural sources, an interesting technique especially when the active substances are relatively complex
  • By chemical means, when the active ingredients are simple
  • and finally, by genetic engineering by inserting a gene coding for a protein into a bacterium, for example.

Why distort the active ingredient of your pharmaceutical products?

This process of deformation is particularly used by manufacturers in order to :

  • Develop a new formulation of the active ingredient
  • Analyze two formulations of the active ingredient in a comparative way (double-sourcing or multi-surcing)
  • Determine the exact composition of the active ingredient
  • Analyze and identify an impurity in the active ingredient

Our solutions: to accompany you in your project of deforming the active ingredient of a pharmaceutical product

Successful deformulation is the result of a good knowledge of the targeted application and the implementation of precise and tailor-made analytical methods.

With its state-of-the-art analytical facilities (a technical platform of more than 2,100 m2) and qualified and experienced staff, FILAB can assist you in your pharmaceutical deformulation projects, with tailor-made monitoring and expertise.

In order to support its customers in their active ingredient deformulation projects, FILAB has a range of diversified and sometimes very advanced techniques:

our resources

  • Gas chromatography coupled to mass spectrometry (GCMS)

  • Spectrometric analysis by ICP-MS and ICP-AES

  • Nuclear magnetic resonance (NMR)

  • Liquid chromatography coupled to mass spectrometry (LCMS)

  • Analysis by liquid chromatography using CLI

  • X-ray Diffraction (XRD)

The positive aspects of FILAB

  • A highly qualified team

  • Responsiveness in responding to and processing requests

  • A complete analytical park of 2100m²

  • Tailor-made support

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