You wish to carry out a TFA (Trifluoroacetic Acid) analysis on raw materials or finished products
What is TFA (Trifluoroacetic Acid)?
Trifluoroacetic acid (TFA) is widely used as a reagent or solubilizing agent in organic chemistry, particularly in synthetic peptides and HPLC purification.
Its residual presence in a finished product can pose toxicity, regulatory compliance, and quality issues.
Accurate TFA analysis is therefore essential for:
- Verifying the purity of your peptides or biomolecules.
- Controlling solvent and reagent residues in accordance with ICH Q3C guidelines.
- Documenting your regulatory dossiers (pharmaceutical, cosmetic, biotechnology).
The FILAB laboratory supports you in the analysis of TFA (Trifluoroacetic Acid)
Our analysis services
Why choose FILAB for TFA analysis?
FILAB, an analytical expertise laboratory, offers TFA (Trifluoroacetic Acid) analysis services using cutting-edge techniques adapted to industrial constraints and regulatory requirements.
Our experts assist you in interpreting results and optimizing your formulations. Thanks to our expertise in analysis, appraisal, and R&D, we help you solve your specific problems and guarantee the quality of your products.
What are the uses of TFA?
TFA is widely used in peptide synthesis as a reagent, particularly to remove protecting groups from amino acids during deprotection steps.
It is also used in purification, where it serves as an additive in liquid chromatography (HPLC) solvents to improve the separation of peptides and proteins.
Finally, in organic chemistry, TFA can be used as a catalyst or solvent in various reactions.
FAQ
TFA (trifluoroacetic acid) is a strong organic acid widely used in organic chemistry, peptide synthesis, and HPLC purification. Its residual presence in a product can pose safety and regulatory compliance issues.
TFA analysis allows the purity of products to be verified, solvent residues to be controlled in accordance with ICH Q3C guidelines, and regulatory dossiers (pharmaceutical, cosmetic, biotechnological) to be secured.
Synthetic peptides, recombinant proteins, cosmetic ingredients, pharmaceutical formulations and certain laboratory solvents are affected.
The most common methods are ion chromatography, HPLC (UV or MS), LC-MS and GC-MS (after derivatization).
Yes, TFA is considered a residual solvent and must be controlled according to ICH Q3C recommendations. Acceptable thresholds depend on the solvent classification and the type of final product.
Mainly the pharmaceutical industry (quality control and registration), cosmetics (ingredient safety) and biotechnologies (peptides, proteins, enzymes).
