Polymorphism analysis and solid-state characterization
What is polymorphism?
In chemistry, polymorphism is the ability of a chemical substance to crystallise in different structures depending on temperature and pressure conditions. These different forms from the same molecule can have very different physical and chemical properties. These differences can significantly impact a product's solubility, bioavailability, and stability.
Why characterize crystal phases?
Using a specialized polymorphism analysis laboratory allows manufacturers to control the “solid-state” health of their materials. Precise characterization helps avoid unexpected phase transitions during manufacturing or storage, which could lead to product non-compliance or loss of activity.
FILAB performs polymorphism analysis of your chemical substances
The FILAB laboratory offers industrialists technical skills and state-of-the-art analytical equipment in order to respond to their requests in the best possible way and to offer them the most appropriate services and tailor-made follow-up for polymorphism analysis.
Our polymorphism analysis services
Active ingredient analysis (API) by XRD and DSC
Development of analytical methods for the determination of polymorphic chemicals
Advanced technical resources for polymorphism analysis
X-ray Diffraction (XRD) for the determination of crystal phases
DSC analysis for determination of melting and crystallisation temperatures
Thermal analysis (differential calorimetry, thermogravimetry)
Light microscopy, scanning electron microscopy
Our FAQ
It is used to identify the different crystalline forms (polymorphs) of a substance. This ensures that the chosen form has the desired physical properties, such as solubility and stability, which are critical for pharmaceutical and chemical applications.
X-ray Diffraction (XRD) is the most powerful tool for identifying crystal phases. However, it is often combined with DSC for thermal behavior and Raman spectroscopy to provide a complete "fingerprint" of the polymorph.
Different polymorphs of the same API can have different dissolution rates. Polymorphism analysis ensures that the drug performs as expected in the body and remains stable throughout its shelf life.
Yes. FILAB provides analytical data compliant with GMP, USP, and ICH guidelines. We support regulatory submissions by providing validated methods and comprehensive characterization reports.
It should be performed during raw material selection, formulation development, and stability testing. It is also essential when changing manufacturing processes or suppliers to ensure the crystal form has not been altered.
Turnaround times vary depending on the nature of the analysis and the complexity of the expert assessment project.
However, FILAB is committed to providing fast turnaround times tailored to your industrial constraints and urgent needs.
To obtain a quote, you can contact our team via our contact form, by phone, or by email.
Simply tell us your requirements (type of material, desired analysis, applicable standards, urgency, quantity of samples, etc.). We will then send you a personalized technical and pricing proposal within 24-48 hours.
