The SP-ICP-MS (Single Particle Inductively Coupled Plasma Mass Spectrometry) technique has become a benchmark for nanoparticle analysis. The FILAB laboratory, an expert in nanomaterials, offers you its skills to accurately characterise the nanoparticles present in your complex matrices.
Your needs: nanoparticle analysis using sp-icp-ms
What is Single Particle analysis (SP-ICP-MS) ?
SP-ICP-MS is a variant of inductively coupled plasma mass spectrometry (ICP-MS). This technique enables :
- Detection and quantification of individual nanoparticles.
- Determine the size and distribution of nanoparticles.
- Identify metallic nanoparticles at extremely low concentrations.
The SP-ICP-MS method is particularly effective for nanomaterials used in the pharmaceutical, cosmetics, environmental and industrial sectors.
Why use SP-ICP-MS to analyse nanoparticles?
Single Particle SP-ICP-MS is a reference method for detecting, quantifying and characterizing nanoparticles. Its precision and versatility make it an indispensable tool for industry and research.
- Individual detection of nanoparticles: SP-ICP-MS allows each nanoparticle to be observed individually, unlike other methods. This provides a precise measurement of the size and concentration of particles in a sample.
- Analysis at very low concentrations: thanks to its exceptional sensitivity, the SP-ICP-MS detects nanoparticles even at sub-ppb concentrations. This meets the requirements of regulatory standards and enables reliable identification of traces of nanomaterials.
- Characterization of size and distribution: the size of nanoparticles, essential for their properties, is accurately measured. SP-ICP-MS provides a complete size distribution, distinguishing individual particles from aggregates, from 10 to 200 nm.
- Identification of chemical composition: the SP-ICP-MS detects the constituent elements of nanoparticles, whether metals or metal oxides. It can therefore be used to identify contaminants or characterise complex nanoparticles.
- Adaptability to a variety of matrices:
- Liquids: wastewater, industrial suspensions.
- Biological: pharmaceutical formulations, serums.
- Dispersed solids: cosmetics, powders.
Regulation of nano-objects by SP-ICP-MS
XP CEN ISO/TS 19590 is a technical specification entitled ‘Nanotechnologies – Characterisation of nano-objects by inductively coupled plasma mass spectrometry in single particle mode’. It provides a methodological framework for the accurate characterisation of nano-objects in aqueous suspension, detailing the essential procedures and parameters for reliable spICP-MS analysis.
The main measurements covered by this standard include:
- Particle number concentration: number of particles per unit volume.
- Particle mass: individual mass of nanoparticles.
- Particle mass concentration: total mass of particles per unit volume.
- Equivalent spherical particle diameter: size of particles assumed to be spherical.
- Particle size distribution by number: distribution of particle sizes according to their number.
Our solutions: using the SP-ICP-MS analysis technique to deliver fast, reliable results
SP-ICP-MS analytical parameters
The SP-ICP-MS provides precise analytical data thanks to :
- Nanoparticle size detection: particle resolution ranging from 10 to 200 nm depending on the matrix.
- Nanoparticle concentration: precise quantification of the number of particles per millilitre (ppb or ppt).
- Elemental composition: identification of the constituent elements of metallic nanoparticles.
SP-ICP-MS applications
The SP-ICP-MS can be applied to a wide range of samples and sectors:
- Pharmaceutical industry: detection of nanoparticles in medical formulations.
- Cosmetics industry: analysis of nanoparticles of titanium oxide (TiO₂) and other additives.
- Environment: characterization of nanoparticles in water (industrial waste, drinking water).
- Food industry: presence of nanoparticles in packaging or food additives.
SP-ICP-MS analysis in the pharmaceutical industry
SP-ICP-MS analysis is used in the pharmaceutical industry to detect, quantify and characterize nanoparticles in medical formulations such as vaccines or nanotechnology treatments. It is used to monitor particle size, distribution and concentration. SP-ICP-MS is also used to identify metallic contaminants introduced during production or packaging, and to assess the biodistribution and nanotoxicity of particles in preclinical studies, ensuring compliance with stringent regulatory standards.
SP-ICP-MS analysis in the cosmetics industry
SP-ICP-MS analysis is used in the cosmetics industry to detect, quantify and characterize nanoparticles present in products such as sunscreens, skincare products and make-up containing nanoparticles of titanium oxide (TiO₂) or zinc oxide. It makes it possible to control the size, distribution and concentration of particles to guarantee their safety, efficacy and compliance with European regulations on nanomaterials, while meeting consumer safety requirements.
SP-ICP-MS analysis in the food industry
In the food industry, SP-ICP-MS analysis is used to detect, quantify and characterize nanoparticles present in food additives (such as titanium dioxide nanoparticles – TiO₂), packaging or contact materials. It can be used to check their size, concentration and distribution, guaranteeing food safety and compliance with regulatory standards. SP-ICP-MS also plays a key role in assessing the potential risks associated with nanoparticle ingestion, helping to protect consumer health while meeting traceability and transparency requirements.
Why choose FILAB for your SP-ICP-MS analysis?
- An ISO 17025 accredited laboratory for reliable, recognised results.
- Multidisciplinary expertise in nanomaterials and analytical chemistry.
- Customised support to meet your specific needs (R&D, quality, compliance).
- State-of-the-art equipment for rapid, ultra-sensitive detection.
FAQ
The SP-ICP-MS is ideal for :
- Detection and characterization of nanoparticles suspended in liquids.
- Analysis of nanomaterials in the environmental, pharmaceutical, cosmetics and industrial sectors.
- Quantifying nanoparticles at extremely low concentrations.
The SP-ICP-MS is particularly well suited to the pharmaceutical industry for detecting and characterising metallic nanoparticles present in medical formulations. It can be used to check their size, concentration and distribution, in order to guarantee the safety and quality of medicines in compliance with regulatory standards.
In the cosmetics sector, SP-ICP-MS can be used to analyse nanoparticles such as titanium oxide (TiO₂) or zinc oxide used in sun creams and skincare products. This technique guarantees accurate quantification of nanoparticles and helps to verify their compliance with European regulations on nanomaterials.
SP-ICP-MS plays a key role in the detection of nanoparticles in wastewater, drinking water and other environmental matrices. It can be used to monitor the dispersion and persistence of nanomaterials in the environment, thereby contributing to ecological impact studies and nanoparticle risk management.
