Laboratory analysis of Hyaluronic acid
Your needs: to inspect the quality of a hyaluronic acid-based wrinkle filler
What is hyaluronic acid?
Hyaluronic acid is a naturally occurring polysaccharide belonging to the glycosaminoglycan family. It is widely present in human tissues, particularly in the skin, joints and connective tissues.
Due to its exceptional water retention capacity, hyaluronic acid plays a key role in maintaining skin hydration, elasticity and tissue lubrication. Because of these properties, it is extensively used in cosmetic products and medical devices, particularly in dermal fillers and anti-aging formulations.
Why perform hyaluronic acid analysis?
Manufacturers need to perform hyaluronic acid analysis to ensure that their products meet quality, safety and performance requirements.
Analytical testing makes it possible to:
- verify the concentration of hyaluronic acid in the formulation
- evaluate the purity of the raw material
- detect potential impurities or contaminants
- assess the stability of the product over time
Reliable laboratory analysis of hyaluronic acid therefore helps manufacturers guarantee the quality and safety of their cosmetic and medical products.
Our solution: to quickly provide you with reliable techniques allowing you to evaluate the quality of your hyaluronic acid-based products
An independent laboratory specialized in hyaluronic acid analysis
As an independent laboratory situated in Dijon, France, FILAB has been active in the cosmetics and Medical Device industries for over 30 years, carrying out compliance testing and inspecting raw materials. (déjà existant)
Our scientists support manufacturers throughout the product lifecycle by performing reliable hyaluronic acid analysis for quality control, regulatory compliance and research and development.
Advanced analytical instrumentation for hyaluronic acid testing
From conception to production, all the way to a product being put on the market, FILAB has a wide range of useful analytical tools (ICP-MS, ICP-AES, GC-MS, IC…) making it possible to study your hyaluronic acid-based products.
These advanced analytical techniques enable our laboratory to perform precise characterization of hyaluronic acid-based formulations and raw materials, ensuring accurate and reproducible results.
Analytical services for hyaluronic acid-based products
FILAB laboratory provides a comprehensive range of analytical services dedicated to the characterization and quality control of hyaluronic acid-based products, including:
- Chemical analysis, determination of hyaluronic acid, BDDE, lidocaine contents, peptides, API (amino acids, vitamins, nucleic acids, sugars, etc)
- Stability testing in accordance with given conditions to evaluate the lifespan and storage conditions of hyaluronic acid-based products
- Heavy metal analysis (under ISO 17025 accreditation)
- Detection of impurities
- Compatibility testing (E&Ls, container/contents interactions)
- Development of analytical methods
- Measurement of molecular weight
- Measurement of viscosity and viscoelastic properties
- Identification of particulate contaminants
- Particle counting according to PE 2.9.19 and USP 788/789
- Determination of heat capacity
These analysis allow manufacturers to verify product composition, detect impurities and ensure the stability of hyaluronic acid formulations.
Support for R&D and product development
Ensuring a quick turnaround for your requests, FILAB laboratory is able to support companies from the cosmetics and healthcare industry in resolving their complex problems and by assisting with R&D projects (literature reviews, scope statements, research into substitutions, synthesis…).
Our experts provide scientific support throughout research, formulation development and product validation, helping manufacturers optimize their hyaluronic acid-based products and accelerate their time to market.
FAQ
Hyaluronic acid is also used in the medical industry. It is used in particular as a filler for filling treatments and for the treatment of certain ocular and articular affections.
Check the quality and purity of the hyaluronic acid used in medical products.
Evaluate the concentration of hyaluronic acid in a medical product to ensure that it meets the required specifications.
Understand the physical and chemical properties of hyaluronic acid: its viscosity, its stability and its filling effect. All these properties allow for its optimization in medical products.
Evaluate the effectiveness of different types of hyaluronic acid in formulation tests to treat specific conditions.
Thus, hyaluronic acid analysis can help a medical manufacturer to ensure that its products comply with quality and safety standards, to optimize their formulation for optimal results and to evaluate their effectiveness in treating different conditions.
Hyaluronic acid is a very popular molecule in the cosmetic industry because of its moisturizing and anti-aging properties. A cosmetic industrialist has to analyze hyaluronic acid to...
Verify the quality and purity of the hyaluronic acid used in the formulation of a cosmetic product.
Determine the concentration of hyaluronic acid in a cosmetic product to ensure that it meets the required specifications.
Evaluate the effectiveness of different types of hyaluronic acid, including hyaluronic acid in formulation tests.
Understand the physical and chemical properties of hyaluronic acid such as its molecular weight or size distribution. Thus, the cosmetic industrial is able to optimize its formulation in a cosmetic product.
In other words, the analysis of hyaluronic acid can help a cosmetic manufacturer to ensure that its products contain the desired active ingredient and to optimize their formulation for optimal results.
Hyaluronic acid analysis can include several analytical parameters depending on the type of product and its intended use.
Typical parameters analyzed in a laboratory include:
- hyaluronic acid concentration
- molecular weight distribution
- presence of crosslinking agents such as BDDE
- impurities and degradation products
- trace elements and heavy metals
- physicochemical stability
These parameters help manufacturers ensure that hyaluronic acid-based formulations meet quality specifications and regulatory requirements.
Hyaluronic acid can be analyzed using several analytical techniques depending on the objectives of the study.
Laboratories may use chromatographic, spectroscopic or elemental analysis techniques to determine the composition and properties of hyaluronic acid.
These analytical methods allow scientists to evaluate the purity, concentration, molecular characteristics and stability of hyaluronic acid used in cosmetic or medical formulations.
Several factors can influence the quality and performance of hyaluronic acid used in cosmetic or medical products.
Key factors include:
- molecular weight and molecular weight distribution
- purity of the raw material
- presence of residual solvents or contaminants
- storage conditions and product stability
Laboratory analysis helps manufacturers monitor these parameters and ensure consistent product quality.
The molecular weight of hyaluronic acid plays a major role in its biological and functional properties.
High molecular weight hyaluronic acid is generally associated with viscoelastic and moisturizing properties, while lower molecular weight fractions may influence skin penetration and biological activity.
Determining the molecular weight distribution of hyaluronic acid is therefore an important step in optimizing cosmetic and medical formulations.
Hyaluronic acid analysis is commonly required in several industries where this molecule is used as an active ingredient.
These include:
- cosmetic manufacturing
- dermal filler production
- pharmaceutical and biomedical applications
- ophthalmic medical devices
- regenerative medicine
Analytical testing ensures that hyaluronic acid used in these applications meets strict quality and safety standards.
Hyaluronic acid testing can be performed at several stages of product development.
Laboratory analysis may be required:
- during raw material qualification
- during formulation development
- during stability studies
- during quality control of finished products
Performing hyaluronic acid analysis throughout the product lifecycle helps manufacturers ensure consistent performance and regulatory compliance.
