Chromatographic laboratory analysis : HPLC, LC-MS, LC-MS/MS, QToF-MS

Liquid chromatography-mass spectrometry analysis (LC-MS analysis) is a powerful analytical technique used to identify and quantify different compounds in complex samples. By separating and identifying the components of a sample, LC-MS analysis can provide detailed information about the composition of a sample, such as its identity, concentration, structure and other characteristics. LC MS analysis is used in areas ranging from drug development to environmental monitoring. The method involves separating the components of a sample by liquid chromatography before analysing them by mass spectrometry to identify them. The data obtained from LC-MS analysis is often used to verify the purity or quality of compounds or to obtain quantitative data to compare samples. LC-MS analysis can be used to measure small amounts of substances such as drugs, toxins, hormones and metabolites in biological samples. It is also used to look for contaminants in food and beverages, detect traces of toxic chemicals in the environment and analyse the contents of pharmaceuticals.

In addition to providing important analytical data, LC-MS analysis is increasingly used for diagnostic purposes, such as detecting metabolic disorders or identifying biomarkers associated with certain diseases. Its use for diagnostic purposes could revolutionise healthcare by providing clinicians with powerful tools for the early detection and treatment of disease. By providing detailed information about the composition of a sample, LC-MS analysis can prove invaluable to research and development efforts, helping researchers to identify new compounds or better understand existing ones.

The main difference between LC-MS and MS/MS analysis is that LC-MS involves the separation of compounds by liquid chromatography before they are analysed by mass spectrometry, which is not the case with MS/MS. In LC-MS, the components of a sample pass through a stationary phase (such as a column) to separate them before being analysed by mass spectrometry. In contrast, in MS/MS analysis, the compound passes directly into the mass spectrometer without being separated first. This results in a faster analysis and increased sensitivity compared to LC-MS. However, because it does not involve any preliminary separation step, MS/MS analysis cannot provide detailed information on the composition or structure of the sample. It is mainly used for qualitative analysis.

At Filab, we offer state-of-the-art LC-MS and MS/MS laboratory analysis services to meet our clients' needs. Our experienced team is committed to providing you with accurate and reliable results in a timely manner. Our LC-MS laboratory is at your disposal for any request.