LC MS and HPLC MS analysis in the laboratory
Your needs : to analyze active substances or impurities in your products using HPLC or LC-MS
In the pharmaceutical, cosmetics and chemical sectors, the detection and identification of trace compounds helps to guarantee the conformity, safety and performance of products.
Using LC MS or HPLC MS analysis, liquid chromatography coupled with mass spectrometry, our laboratory provides an analytical solution tailored to complex matrices and the most stringent regulatory requirements.
What is HPLC MS?
HPLC-MS: High Performance Liquid Chromatography (HPLC) coupled with Mass Spectrometry (MS) is used to identify and quantify non-volatile organic substances in various matrices.
It is a particularly useful technique for analysing cosmetics and pharmaceutical products in the laboratory, although it can be applied to all industries.
What is LC MS analysis?
LC-MS (Liquid Chromatography-Mass Spectrometry) is a powerful analytical technique that combines the separation capabilities of liquid chromatography (LC) with the chemical analysis capabilities of mass spectrometry (MS).
Liquid chromatography (LC) is used to separate the different components of a mixture. In LC, the sample is dissolved in a solvent and passed through a column containing a stationary phase. The different compounds in the sample interact with this material in different ways and move at different speeds, enabling them to be separated.
Mass spectrometry (MS): after separation by LC, the compounds are analysed using this technique, which identifies the compounds by measuring the mass/charge ratio of their ions. The ions are separated according to their mass and charge. The mass spectrometer then produces a spectrum that can be used to determine the molecular mass of compounds and to identify their chemical structure.
Analysis of impurities by LC MS or HPLC MS
Impurity analysis using LC-MS (Liquid Chromatography-Mass Spectrometry) or HPLC-MS (High-Performance Liquid Chromatography-Mass Spectrometry) is a technique used in many fields, particularly in the pharmaceutical industry.
The combination of LC and MS allows specific analysis of complex mixtures. These methods are used to detect, identify and quantify impurities or contaminants present in a sample.
Our solutions: liquid chromatography analysis (LC and HPLC) coupled with an MS or MS/MS detector
For over 30 years, our FILAB laboratory has had the experience and specific analytical equipment to support companies in LC MS or HPLC MS analysis for the control of raw materials or finished products through tailor-made support.
LC-MS or HPLC-MC: state-of-the-art equipment
Liquid chromatography (HPLC) coupled to a mass (MS) or mass-mass (MS-MS) detector is used to determine the purity of raw materials or compounds in a sample.
LC MS analysis in the laboratory enables precise identification and quantification of compounds in complex samples. From the pharmaceutical sector to the chemical industry, our state-of-the-art LC-MS equipment is the solution of choice for the detection of impurities and contaminants to the characterisation of new compounds. When you choose our laboratory for your LC-MS analysis needs, you benefit from cutting-edge technology and expertise in impurity analysis.
The advantages of LC MS or HPLC MS analysis
LCMS or HPLCMS analysis uses chromatography coupled with spectrometry.
Our services using LC MS or HPLC MS
LC MS - HPLC MS
Dosage of active ingredients
Impurity analysis
Development of analytical methods
Validation of analytical methods
Why use an LC-MS analysis laboratory?
Liquid chromatography coupled to mass spectrometry (LC-MS) is a state-of-the-art technique for identifying, quantifying and characterising organic or organometallic compounds, even at trace levels (ng/mL or less).
It is essential when it comes to analysing complex matrices or validating the conformity of products and materials in demanding industrial contexts.
Liquid chromatography-mass spectrometry (LC-MS analysis) is a powerful analytical technique used to identify and quantify different compounds in complex samples. By separating and identifying the components of a sample, LC-MS analysis can provide detailed information about the composition of a sample, such as its identity, concentration, structure and other characteristics. LC MS analysis is used in sectors ranging from drug development to environmental monitoring. The method involves separating the components of a sample using liquid chromatography before analysing them using mass spectrometry to identify them. The data obtained from an LC-MS analysis is often used to verify the purity or quality of compounds or to obtain quantitative data for comparing samples. LC-MS analysis can be used to measure small quantities of substances such as drugs, toxins, hormones and metabolites in biological samples. It is also used to look for contaminants in food and drink products, detect traces of toxic chemicals in the environment and analyse the contents of pharmaceutical products.
As well as providing important analytical data, LC-MS analysis is increasingly being used for diagnostic purposes, notably to detect metabolic disorders or identify biomarkers associated with certain diseases. Its use for diagnostic purposes could revolutionise healthcare by providing clinicians with powerful tools for the early detection and treatment of disease. By providing detailed information about the composition of a sample, LC-MS analysis can prove invaluable to research and development efforts, helping researchers to identify new compounds or better understand existing ones.
The main difference between LC-MS and MS/MS analysis is that LC-MS involves the separation of compounds by liquid chromatography before they are analysed by mass spectrometry, which is not the case with MS/MS. In LC-MS, the components of a sample pass through a stationary phase (such as a column) to separate them before being analysed by mass spectrometry. In MS/MS analysis, on the other hand, the compound passes directly into the mass spectrometer without first being separated. This results in faster analysis and greater sensitivity than LC-MS. However, because it involves no preliminary separation step, MS/MS analysis cannot provide detailed information about the composition or structure of the sample. It is mainly used for qualitative analysis.
At the Filab laboratory, we offer state-of-the-art LC-MS and MS/MS laboratory analysis services to meet our customers' needs. Our experienced team is committed to providing you with accurate and reliable results in the shortest possible time. Our LC-MS laboratory is at your disposal for any requests you may have.
The main difference between LC-MS and HPLC-MS lies in the type of liquid chromatography used.
In HPLC, resolution and separation efficiency are generally higher than in traditional LC methods. This is due to the use of finer columns, smaller stationary phase particles and higher operating pressures in HPLC. HPLC-MS is often preferred in situations where high sensitivity and precision are required, such as in the analysis of trace contaminants.
