You would like to check the presence of TFA in your samples
What is TFA (Trifluoroacetic Acid)?
TFA: an ultra-short-chain PFAS
Trifluoroacetic acid (TFA, CAS 76-05-1) is a highly persistent and mobile PFAS. Produced through industrial processes or the degradation of fluorinated compounds, it is subject to increased monitoring by manufacturers.
Our laboratory performs analyses to meet your diverse needs and help you manage its presence and meet your regulatory obligations. With its 5,200 m² analytical facility, Filab can detect TFA and other PFAS in various matrices.
PFAS, where are we in the regulations?
Thursday, February 20, 2025
On Thursday, February 20, 2025, the National Assembly adopted a bill aimed at better regulating the use of per- and polyfluoroalkyl substances (PFAS).
Known for their persistence in the environment and their ability to accumulate in living organisms, these “eternal pollutants” are present in many everyday objects.
The bill provides for a ban on the manufacture, importation, and sale of any cosmetic product, clothing textile, or ski wax containing PFAS starting January 1, 2026.
The FILAB laboratory supports you in the analysis of TFA (Trifluoroacetic Acid)
Our analysis services
Detection of residual TFA in a product
Why choose FILAB for TFA analysis?
FILAB, an analytical expertise laboratory, offers TFA (Trifluoroacetic Acid - CAS 76-05-1) ) analysis services using cutting-edge techniques adapted to industrial constraints and regulatory requirements.
Our experts assist you in interpreting results and optimizing your formulations. Thanks to our expertise in analysis, appraisal, and R&D, we help you solve your specific problems and guarantee the quality of your products.
FAQ
TFA (trifluoroacetic acid) is a strong organic acid widely used in organic chemistry, peptide synthesis, and HPLC purification. Its residual presence in a product can pose safety and regulatory compliance issues.
TFA analysis allows the purity of products to be verified, solvent residues to be controlled in accordance with ICH Q3C guidelines, and regulatory dossiers (pharmaceutical, cosmetic, biotechnological) to be secured.
Synthetic peptides, recombinant proteins, cosmetic ingredients, pharmaceutical formulations and certain laboratory solvents are affected.
The most common methods are ion chromatography, HPLC (UV or MS), LC-MS and GC-MS (after derivatization).
Yes, TFA is considered a residual solvent and must be controlled according to ICH Q3C recommendations. Acceptable thresholds depend on the solvent classification and the type of final product.
Mainly the pharmaceutical industry (quality control and registration), cosmetics (ingredient safety) and biotechnologies (peptides, proteins, enzymes).
