Le test de solubilité selon l’OCDE 105 est une méthode normalisée permettant de déterminer la solubilité aqueuse d’une substance chimique. Ce test est essentiel pour évaluer le comportement d’une substance dans l’environnement et dans divers processus industriels. La solubilité d’une substance dans l’eau représente sa concentration de saturation dans l’eau à une température définie.
You wish to perform a solubility test according to OECD 105
OECD 105: Measurement of water solubility and REACH validation
Accurately determine the solubility of your substances and secure your regulatory dossiers with the expertise of FILAB, a leader in physicochemical characterization.
Water solubility is one of the fundamental properties required for the registration of chemical substances under the REACH regulation. For materials at the nanoscale, this test is the first critical filter: it determines whether your product must follow the complex process for "nanomaterials" or whether it can be treated as a conventional soluble substance.
Principle of the OECD 105 solubility test
The test consists of determining the maximum concentration of a substance dissolved in water under equilibrium conditions, at a controlled temperature. Two methods are recommended for carrying out this test:
- Suitable for substances with a solubility of less than 10^-2 g/L.
- The substance is suspended in water and stirred until equilibrium is reached.
- After filtration or centrifugation, the concentration is measured using an appropriate analytical technique (HPLC, UV-Vis, GC, etc.).
- Suitable for substances with a solubility of less than 10^-2 g/L.
- Water saturates the substance in a column, and the eluate is analysed to determine the concentration in solution.
The FILAB laboratory performs solubility tests according to OECD 105
Our technical means for analysis according to OECD 105
Column Elution Method
for poorly soluble substances (< 10 mg/L)
Flask Method
for more soluble substances (> 10 mg/L)
ICP-AES / ICP-MS
to measure metal ions with extreme sensitivity
HPLC-UV / LC-MS
for complex organic molecules
GC
for volatile or semi-volatile substances
COT-Mètre
for an overall measurement of the solubility of an organic mixture
Why perform an OECD 105 solubility test?
You may need to carry out a solubility test in various contexts:
Regulatory safety tests
Toxicological evaluation
Registration of a new chemical substance under REACH
Development of a new product
Why use FILAB?
Mutual Recognition of Data (MAD): In accordance with OECD principles, the data generated by our laboratory is recognized by all OECD member countries. This avoids duplication of testing and facilitates your global exports.
COFRAC ISO 17025 accreditation: a guarantee of scientific rigor, essential for the validity of your dossiers with ECHA.
Nanomaterials expertise: our experts advise you on the most relevant testing strategy for your substance.
Our other nanomaterials expertise services
The FILAB laboratory is ISO 17025 accredited by COFRAC for the characterization of nanomaterials!
our services
Development and validation of nanomaterial-specific analytical methods
Training for your teams (techniques and regulatory issues related to nanomaterials)
Regulatory consulting on nanomaterials (2011 EC Recommendation, EC Cosmetics Regulation n°1223/2009, INCO Regulation n°1169/2011, R-Nano (2012-232, 02/2012)...)
OUR TECHNICAL RESOURCES
SEM-FEG-EDX : counting and determining the size and shape of nanoparticles
Helium pycnometry : density measurement
XRD : structural analysis
DLS : measurement of nano-emulsions and study of suspension stability by Zeta Potential titration.
SP-ICP-MS: detection of nanoparticles
BET : specific surface measurement
Laser granulometry : particle size distribution
ICP-AES and ICP-MS : trace analysis and chemical composition of a nanomaterial-based product
To go further
Determination of regulated substances: heavy metals, phthalates, nitrosamines, bisphenol A, residual solvents
Our FAQ
Test No. 105 is a guideline for analyzing the solubility of chemicals using specific tests. OECD 105 aims to identify and define the potential hazards of new chemicals, chemical preparations, and chemical mixtures.
Therefore, according to the OECD Guidelines for Chemical Testing, Section 1, solubility determination methods are performed on pure, non-volatile substances that are stable in water.
At the FILAB laboratory, we perform solubility tests under conditions defined and validated with the client, based on their specific needs and application.
Thanks to our state-of-the-art analytical equipment (including 15 ICP analyzers), we conduct solubility tests on a variety of raw materials, particularly those at the nanoscale.
To obtain a quote, you can contact our team via our contact form, by phone, or by email.
Simply tell us your requirements (type of material, desired analysis, applicable standards, urgency, quantity of samples, etc.). We will then send you a personalized technical and pricing proposal within 24-48 hours.
Turnaround times vary depending on the nature of the analysis and the complexity of the expert assessment project.
However, FILAB is committed to providing fast turnaround times tailored to your industrial constraints and urgent needs.
