Solubility testing in accordance with the OECD 105

A substance’s solubility in water represents its saturation concentration in water at a given temperature.

You may be required to carry out solubility testing for various reasons :

  • Regulatory safety testing
  • Registration of a new chemical substance in line with the REACH regulation
  • Toxicological examination
  • Development of a new product 

Following the OECD’s guidelines surrounding tests on chemical substances, Section1, methods for determining solubility are to be carried out using pure, non-volatile, stable samples.

Before measuring solubility, it is important to give information on the substance such as its structural formula, vapor pressure, dissociation constant and hydrolysis based on pH.

The column elution method and the flask method cover solubilities lower than and higher than 10-2 g/L respectively. The test is carried out at 20 ± 0.5°C. Simple preliminary testing is carried put to approximatively determine the sample size (i.e. the amount of substance) needed to carry out the test as well as to determine the time needed to reach saturation.

Here at FILAB, we carry out solubility testing following specific conditions set and validated by the client in accordance with their request and their field. Thanks to our cutting-edge analytical fleet spread over 2100m² (including over 10 ICP machines) we are able to carry out solubility testing on various raw materials, most notably, on the nanometric scale.

Thomas GAUTIER Head of Materials Department
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