The OECD 105 solubility test is a standardized method used to determine the aqueous solubility of a chemical substance. This test is essential for assessing a substance’s behavior in the environment and in various industrial processes. A substance’s solubility in water represents its saturation concentration in water at a defined temperature.
Would you like to carry out an OECD 105/OECD 105 solubility test
OECD 105: measuring water solubility and REACH compliance
Accurately determine the solubility of your substances and secure your regulatory files thanks to FILAB’s expertise, a leader in physicochemical characterization.
Water solubility is one of the fundamental properties required for the registration of chemical substances under the REACH regulation. For nanometric materials, this test is the first critical filter: it determines whether your product must follow the complex pathway for “nanomaterials” or whether it can be treated as a conventional soluble substance.
Principle of the OECD 105 solubility test
The test consists of determining the maximum concentration of a substance dissolved in water under equilibrium conditions, at controlled temperature. Two methods are recommended for carrying out this test:
- Suitable for substances with solubility below 10^-2 g/L.
- The substance is suspended in water and shaken until equilibrium is reached.
- After filtration or centrifugation, the concentration is measured using an appropriate analytical technique (HPLC, UV-Vis, GC, etc.).
- Suitable for substances with solubility below 10^-2 g/L.
- Water saturates the substance in a column, and the eluate is analyzed to determine the concentration in solution.
FILAB laboratory carries out OECD 105 solubility tests
Our technical resources for OECD 105 analysis
Column elution method
for poorly soluble substances (<10 mg/L)
Flask method
for more soluble substances (> 10 mg/L)
ICP-AES / ICP-MS
for measuring metal ions with extreme sensitivity
HPLC-UV / LC-MS
for complex organic molecules
GC
for volatile or semi-volatile substances.
Why carry out a solubility test according to OECD 105?
You may be required to carry out a solubility test in various contexts:
Regulatory safety tests
Toxicological assessment
Registration of a new chemical substance under REACH
Development of a new product
Why choose FILAB?
Mutual Acceptance of Data (MAD): in accordance with OECD principles, the data generated by our laboratory are recognized by all OECD member countries. This avoids duplicate testing and makes your global exports easier.
COFRAC ISO 17025 accreditation: a guarantee of scientific rigor that is essential for the validity of your files with the ECHA.
Nanomaterials expertise: our experts advise you on the most relevant testing strategy for your substance.
Research Tax Credit (CIR): FILAB is an approved laboratory, enabling you to optimize your R&D and compliance budgets.
Our other nanomaterials expertise services
The FILAB laboratory is ISO 17025 accredited by COFRAC for nanomaterials characterization!
our services
Development and validation of analytical methods specific to nanomaterials
Training for your teams (technical aspects and regulatory requirements related to nanomaterials)
Regulatory consulting for nanomaterials (EC Recommendation of 2011, EC Cosmetics Regulation No. 1223/2009, INCO Regulation No. 1169/2011, R-Nano (2012-232, 02/2012)...)
OUR TECHNICAL RESOURCES
FEG-SEM-EDX: counting and determining the size and shape of nanoparticles
Helium pycnometry: density measurement
XRD: structural analysis
DLS: nano-emulsion measurement and suspension stability study by zeta potential titration.
SP-ICP-MS: nanoparticle detection
BET: specific surface area measurement
Laser particle size analysis: particle size distribution
ICP-AES and ICP-MS: trace and chemical composition analysis on a nanomaterials-based product
to go further
Determination of regulated substances: heavy metals, phthalates, nitrosamines, bisphenol A, residual solvents
Our FAQ
Test No. 105 is a guideline for the analysis of the solubility of chemicals according to specific tests. Indeed, OECD 105 aims to identify and define the potential hazards of new chemical substances, chemical preparations and chemical mixtures.
Thus, according to the OECD Guidelines for the Testing of Chemicals, Section 1, solubility determination methods are carried out on pure, non-volatile substances that are stable in water.
At FILAB laboratory, we carry out solubility tests under conditions defined and validated with the client according to their needs and field of application.
Thanks to state-of-the-art analytical equipment (including 15 ICPs), we perform solubility tests on a wide range of raw materials, including nanometric-sized materials.
To get a quote, you can contact our teams via our contact form, by phone or by email.
All you need to do is send us your requirements (type of material, analysis requested, any standard to be applied, urgency, number of samples, etc.). We will then send you a tailored technical and pricing proposal within 24-48 hours.
Lead times vary depending on the nature of the analysis and the complexity of the expert assessment project.
However, FILAB is committed to providing fast turnaround times adapted to your constraints and industrial urgencies.
