Would you like to analyze the nitrosamines present in your cosmetics according to the ATNC method?
Why analyze nitrosamines in your products or raw materials?
Preventing the formation of nitrosamines is a comprehensive strategy established by cosmetics regulations and the recommendations of professional organizations. This requires manufacturers to carry out accurate nitrosamine analysis.
Indeed, nitrosamines have been classified as hazardous substances and potentially carcinogenic to humans by the IARC and WHO. This is why strict European Regulation (EC) No. 1223/2009 was established, stating that nitrosamines should not be part of the composition of cosmetic products above technically unavoidable trace levels under good manufacturing practices.
Our nitrosamine analysis
FILAB laboratory has developed precise and optimized analytical methods to detect and quantify, among others, the following nitrosamines using the LC-MS/MS :
- NDMA (CAS: 62-75-9)
- NDEA (CAS: 55-18-5)
- NEIPA (CAS: 16339-04-1)
- NDIPA (CAS: 601-77-4)
- NMBA (CAS: 61445-55-4)
- NDBA (CAS: 924-16-3)
- NMPA (CAS: 614-00-6)
- NDPA (CAS: 621-64-7)
- NMEA (10595-95-6)
- NMOR (59-89-2)
- NPYR (930-55-2)
- NPIP (621-64-7)
- NMPEA (13256-11-6)
- NDELA (1116-54-7)
- NDPh/NDPhA (86-30-6)
- MeNP (16339-07-4)
- NMPH (55557-03-4)
- NEPhA (612-64-6)
- NDINA (1207995-62-7)
- NDSRI
The detection limits for nitrosamine quantification range from 1 to 10 µg/kg depending on the matrix and nitrosamine.
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FILAB laboratory analyzes and quantifies nitrosamines using the ATNC method (determination of the apparent total nitrosamine content) in your cosmetics and other matrices
To support cosmetics manufacturers in the development and quality control of their products while keeping pace with regulatory changes, the laboratory provides state-of-the-art analytical equipment for quantifying nitrosamines according to the ATNC method (Apparent Total Nitrosamines Content).
What is the ATNC method?
The GC-TEA ATNC method (Gas Chromatography coupled to Thermal Energy Analyzer for Analysis of Apparent Total N-Nitroso Compounds) is an analytical technique specialized in the detection and quantification of apparent total N-nitroso compounds (ATNC). These compounds are potentially carcinogenic substances formed by the nitrosation of amines in the presence of nitrites, particularly in food, pharmaceutical, or environmental contexts.
Detection limits for nitrosamine quantification range from 1 to 10 µg/kg (ppb), depending on the nitrosamine and matrix type.
Why choose FILAB for your nitrosamine analysis according to the ATNC method?
To address these challenges, you are looking for the support of a reliable, independent analytical laboratory specialized in cosmetics and offering high technical added value.
FILAB, a laboratory staffed by experts in cosmetic analysis and failure characterization, offers analytical services from the design and manufacture of a cosmetic product through to its market launch (makeup, cream, perfume, etc.).
Our cosmetic chemical analysis
analysis of undesirable substances in raw materials and finished products: heavy metals, residual solvents, phthalates, bisphenol A, 1,4-dioxane, nitrosamines (ATNC method), D4/D4/D6 siloxanes...
Packaging analysis : polymers, composites, glass
Our FAQ
Filab is an accredited, high-performance ATNC testing laboratory offering its services throughout Europe.
Our ATNC testing services in Europe include:
- Total apparent nitrosamines content (ATNC) by GC-TEA: This advanced technique enables the accurate detection and quantification of the total amount of nitrosamines present in a sample.
- TEA nitrosamines analysis for the pharmaceutical and cosmetic industries: We guarantee product safety by assessing the absence of contamination using the ATNC method in raw materials, intermediate products and finished products, in accordance with current regulations.
Our strengths as an ATNC testing laboratory in Europe:
- In-depth scientific and technical expertise: Our team of experienced analysts is at the forefront of the latest ATNC testing techniques, ensuring accurate and reliable results.
- Accredited laboratories equipped with cutting-edge instruments: Our state-of-the-art facilities meet the strictest standards for ATNC testing, ensuring the quality and consistency of results.
- A methodical and rigorous approach: We apply rigorous procedures and strict quality controls to guarantee the validity and reliability of every analysis.
Our laboratory offers a comprehensive range of ATNC tests covering a wide variety of samples. Our experts rely on cutting-edge techniques, such as gas chromatography coupled with thermionic analysis detection (GC-TEA) and mass spectrometry (MS), to ensure accurate and reliable testing. Filab specializes in the analysis of nitrosamines, potentially carcinogenic organic compounds found in a variety of products, including cosmetics, medicines and food. We offer total nitrosamines content (ATNC) testing by GC-TEA, as well as specific analysis of individual nitrosamines, such as N-nitrosodiethanolamine (NDELA) and N-nitrosomethylethanolamine (NMEA).
Our laboratory has recognized expertise in ATNC and nitrosamine testing, enabling us to meet the specific needs of all types of industries, including:
- Pharmaceutical industry: Analysis of raw materials, intermediate products and finished products to ensure the absence of contamination and nitrosamines using the ATNC method.
- Cosmetic industry: Analysis of ingredients, formulations and finished products to ensure compliance with current regulations and consumer safety.
Our strengths:
- Cutting-edge scientific and technical expertise
- Highly qualified and experienced team of analysts
- Laboratories equipped with the latest-generation instruments
- Methodical and rigorous approach
- Delivery of comprehensive and interpreted analysis reports
- Compliance with deadlines and regulatory requirements
Contact us for customized ATNC nitrosamine testing.
Our team is available to provide further information about our nitrosamine testing services using the ATNC method and answer your specific questions. We can also offer customized analysis that perfectly meet your needs and regulatory requirements.
nitrosamines are a group of chemical compounds, more specifically nitrous acid amides, formed through a chemical reaction between secondary amines and nitrosating compounds. They are often produced unintentionally during industrial processes and are widely recognized for their carcinogenic potential.
