Analysis by LC-Orbitrap in the laboratory
Do you need LC-Orbitrap analysis?
Qu’est-ce que la spectrométrie de masse Orbitrap ?
Orbitrap mass spectrometry is an ultra-precise analysis technique that measures the exact mass of molecules present in a sample. It is used to identify, characterize and quantify even trace compounds.
This technology is based on an “Orbitrap” type analyzer, capable of delivering very high resolution and exceptional mass accuracy, often to within a few ppm (parts per million). It is generally coupled with upstream liquid chromatography (LC), hence the name LC-Orbitrap.
How does Orbitrap mass spectrometry work?
Firstly, Orbitrap mass spectrometry allows the trapping of ions by an electrostatic field. These ions have a variable axial oscillation frequency depending on their mass to charge ratio, which allows them to be separated.
The Orbitrap consists of a central electrode and a cylindrical outer electrode. The central electrode, coaxial with the inner axis, traps the ions in an orbital motion and a mass spectrum can then be generated from the detector which converts the induced current image of the trapped ions into a frequency spectrum using the Fourier transform.
Therefore, Orbitrap mass spectrometry offers quantitative mass spectrometry coupled to liquid chromatography (LC-MS) with high mass resolution and accuracy (HRAM).
Analysis by LC-Orbitrap
Determine the molecular weight of an organic compound
Search for impurities at the root of a defect
Check the conformity of a raw material or finished product
Develop analytical methods specific to your products, including mass spectrometry
Our solutions: combining mass spectrometry with Orbitrap to provide you with reliable and accurate results
Why choose FILAB for LC-Orbitrap analysis?
At FILAB, we guarantee our customers accurate, reliable and fully documented analysis, carried out within a rigorous framework.
You benefit from personalized technical and regulatory support, tailored to your sector and your challenges.
Thanks to our full range of analytical equipment, we are able to combine LC-Orbitrap analysis with other complementary techniques (GC-MS, ICP, SEM, FTIR, etc.), to gain a deeper understanding of your issues.
The advantages of LC-Orbitrap analysis
Very high resolution to distinguish molecules very close in mass
High sensitivity for detection of trace substances
Non-targeted analysis possible for identification of unknown compounds
High mass accuracy, useful for elucidating the structure of molecules
