The standard NF ISO 13779-3 describes the chemical analysis and characterization of the crystallinity and phase purity of hydroxyapatite powders (HAP) used in surgical implants.
No surgical implant material is completely biologically and chemically inert to the human body. Nevertheless, clinical studies on the use of PAH powders have shown that biological reactivity can be tolerable.
The chemical analysis consist of the determination of arsenic, mercury, cadmium and lead on calcium phosphate coatings by an ICP spectrometric method.
Characterization analysis by Fourier Transform Infrared Spectroscopy (FTIR) allow to verify the absence of oxyapatite.
The hydroxyapatite powders (HAP) are composed of different crystalline phases:
– Tricalcium phosphate b
– Tricalcium phosphate a
– Apatite
– Tetracalcium phosphate
– Calcium oxide
The analysis of quantification of the crystallinity consist in the determination of the ratio Ca : P by X-Ray Diffraction (XRD). The analysis of characterization of the crystallinity by X-Ray Diffraction consist in :
– determining qualitatively and quantitatively the foreign phases
– determining the proportion of correctly crystallized apatitic phase (crystallinity ratio)
FILAB has significant experience in the development of specific methods and can assist you in the analysis and characterization of your PAH hydroxyapatite powders using various analytical techniques.
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