You would like to perform the determination of propionic/propanoic acid (CAS No. 79-09-4) present in your matrices
Ensure the conformity, preservation and quality of your products with cutting-edge analytical expertise on propionic/propanoic acid (CAS No. 79-09-4)
Propionic acid (or propanoic acid) is a key molecule whose analytical control is essential to guarantee patient safety, the stability of skincare formulations, and the mechanical properties of polymer materials.
FILAB laboratory provides high-precision assay solutions adapted to the most complex matrices and the strictest regulatory environments (GMP, ISO, ICH).
Specific challenges by sector of activity
Propionic/propanoic acid analysis services for the pharmaceutical industry
In the Pharmaceutical industry, propionic acid is used as a precursor in synthesis (particularly for non-steroidal anti-inflammatory drugs such as ibuprofen) or as a preservative.
- Purity control: analysis of residual solvents and organic impurities according to ICH Q3C guidelines.
- Stability of active ingredients: monitoring of propionic ester degradation.
- Trace analysis: precise quantification to ensure the absence of risks.
Propionic/propanoic acid analysis services for cosmetics
Used for its antifungal and antimicrobial properties, propionic acid must be precisely dosed to comply with Cosmetic Regulation (EC) No. 1223/2009.
- Regulatory compliance: verification of concentration limits for preservatives.
- Formula integrity: influence on the acid-base balance (pH) and texture of emulsions.
Propionic/propanoic acid analysis services for the polymer industry
Propionic acid is a key reagent in the manufacture of plastics, particularly cellulose acetopropionate (CAP).
- Materials characterization: determination of residual free acid after polymerization.
- Migration tests: for polymers intended for medical or food contact applications, measurement of propionic acid release in simulants.
- Physicochemical properties: evaluation of the impact of acid residues on the viscosity and durability of polymers.
Our technical ressources for the determination of propionic/propanoic acid (CAS No. 79-09-4)
The FILAB laboratory assists you in the determination of propionic/propanoic acid (CAS No. 79-09-4)
Securing the shelf life
Avoid disputes related to odors or residual impurities
Optimizing polymerization processes
Certify compliance with international monographs
Why choose FILAB for the determination of propionic/propanoic acid (CAS No. 79-09-4)?
For over ten years, the FILAB laboratory has developed extensive expertise in chemical analysis. Our laboratory boasts state-of-the-art analytical equipment and highly skilled personnel to provide services that meet your compliance requirements for the analysis of propionic/propanoic acid (CAS No. 79-09-4).
FAQ
Our quantification limits are tailored to your regulatory requirements. Using GC-MS (Gas Chromatography-Mass Spectrometry), we can achieve levels on the order of ppm (mg/kg), or even lower depending on the complexity of the matrix. These levels are essential for detecting residual impurities in active pharmaceutical ingredients (APIs) or for migration testing in polymers.
Propionic acid is a naturally volatile, short-chain fatty acid. Gas Chromatography (GC) is therefore the reference technique:
- Selectivity: it allows for the precise differentiation of propionic acid from acetic or butyric acid.
- Sensitivity: coupling with mass spectrometry (MS) enables definitive identification of the molecule, eliminating any risk of false positives in complex matrices such as filled polymers or cosmetic creams.
For polymers (e.g., cellulose acetopropionate), we generally use the Headspace technique coupled with GC. The sample is heated in a sealed vial to release residual acid in gaseous form before analysis. This avoids dissolving the polymer in solvents that could interfere with the analysis or degrade the column.
Yes. For the pharmaceutical industry, we develop and validate our methods according to ICH Q2(R1) guidelines (specificity, linearity, accuracy, precision). We also ensure compliance with ICH Q3C guidelines regarding residual solvents and impurities.
An imprecise dosage presents two risks:
- Chemical instability: propionic acid strongly influences pH. A variation can lead to the denaturation of other ingredients or the separation of an emulsion.
- Sensory risk: due to its very strong organic odor, a slight overdose can alter the olfactory profile of your finished product, even in the presence of fragrances.
To get a quote quickly (within 24-48 hours), please contact our sales team at the following address : contact@filab.fr
