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Reverse engineering of plastic (polymer) matter
Your needs: to identify the chemical composition of a polymer or composite material
You are looking to reverse engineer polymer or composite materials with the aim of :Determining the chemical composition of a reference materialVerifying that polymers comply with their Safety Data Sheet (SDS)Comparing the physicochemical properties of multiple plastic products
Our solution: to provide you with a wide range of diverse techniques for characterizing polymers
Our laboratory’s analytical services
For over 30 years, FILAB laboratory has had the experience and specific analytical fleet to be able to assist companies in physiochemically characterizing their plastic and polymer materials.FILAB is able to provide a combination of analytical techniques to reverse engineer a polymer by studying their properties and chemical composition of your polymers :Infrared microscopy (FTIR) : polymer family identificationGC-MS : detection of organic additivesICP : detection of mineral elements (fillers and additives)SEM FEG EDX : dimensional and morphological observationsGPC : molecular weight measurementPy-GC-MS : characterization of the presence of organic additivesTGA-FTIR : identification of released gasses based on temperatureXRD : study of crystalline phasesDSC : polymerization measurements
Why FILAB?
As an independent laboratory with a team made up of highly qualified personnel, FILAB guarantees the reliability of its results, a quick turnaround for requests and tailored support for clients.
Our services
Reverse Engineering in Laboratory
You want to determine the composition of a product by the reverse engineering method.
Reverse engineering, also called deformation or reverse engineering, is a method to determine the chemical composition of a complex mixture using various chemical analysis.In addition to providing a better understanding of a material, reverse engineering allows for a better understanding of structural issues but also its defective quality. Thus, the objective of reverse engineering can, among other things, be to improve the performance of a material and/or to better target a new supplier.This application concerns different types of products, formulas and materials: paints, metals, alloys, varnishes, plastics, cosmetics, aqueous formulations, composites...The method of successful reverse engineering lies in a good knowledge of the targeted application and the implementation of rigorous analytical methods to characterize the composition of organic and mineral fractions.
FILAB supports you in your reverse engineering efforts
Reverse engineering can be used to meet various needs such as:
Our services
Analyze and determine the composition of an unknown mixture
Check compliance with a Safety Data Sheet (SDS) or a technical data sheet
Compare the composition of several products (double-sourcing or multi-sourcing)
Analyze and identify a pollution or an impurity
Par ailleurs, l'ingénierie inverse implique un ensemble de techniques diversifiées, parfois très pointues notamment:
our resources
Gas chromatography coupled to mass spectrometry (GCMS)
XRD
FTIR
Scanning Electron Microscopy (SEM)
Nuclear Magnetic Resonance (NMR analysis)
Liquid chromatography coupled to mass spectrometry (LCMS)
ICP-MS
Thanks to its experience and its state-of-the-art analytical facilities (2100m² analytical laboratory), FILAB laboratory can assist you with your most complex reverse engineering analysis needs, whatever the nature of your sample: aqueous solution, powder, polymer, ceramic, metallic material...
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Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Sectors of activity
Laboratory reverse engineering of a pharmaceutical product
Your needs : to reverse engineer a pharmaceutical product to identify and quantify the substances making up the product
What is reverse engineering ?
Deformulation or reverse engineering of a pharmaceutical product (injectable solutions, drugs, packaging materials…) is a process of analytical decomposition with the aim of separating, identifying and quantifying the substances making up the product, these are the active ingredient (API) and excipients. Reverse engineering requires the use of many different types of chemical analysis.
Why reverse engineer your pharmaceutical products ?
This process is often used in industry for :The development of a new pharmaceutical productComparative analysis between similar products (double sourcing or multi-sourcing) or packaging materialsThe determination of the exact composition of a pharmaceutical productAssessing and verifying the compliance of substances used in a pharmaceutical product compared to an SDS (Safety Data Sheet)Analyzing and identifying an impurity found in a pharmaceutical product
Our solution : to assist you with the process of reverse engineering your pharmaceutical product
The success of this process leads to a better understanding of the product and to the implementation of precise, tailored analytical methods.Equipped with a cutting-edge analytical fleet spread over 2100m² and working with qualified and experienced partners, FILAB is able to assist you with the process of reverse engineering your pharmaceutical product while providing tailored support.To best assist clients in reverse engineering their products, FILAB uses a variety of techniques :Gas Chromatography paired with Mass Spectrometry (GC-MS)Liquid Chromatography paired with Mass Spectrometry (LC-MS)ICP-MS and ICP-AES spectrometryIon Chromatography (IC)Scanning Electron Microscopy paired with an EDX microprobe (SEM FEG EDX)Nuclear Magnetic Resonance (NMR)Infrared Microscopy (FTIR)…
Our services
Laboratory reverse engineering services
Determine product composition through reverse engineering services
What is reverse-engineering ?
The FILAB laboratory performs Reverse Engineering analysis. Reverse Engineering is a method of determining the chemical composition of a complex mixture by means of various chimical analysis.Reverse engineering enables us to gain a better understanding of a material, its structural problems and its failures. The aim is to improve a material's performance or better target a new supplier.The key to successful Reverse Engineering lies in a thorough understanding of the target application and the use of rigorous analytical methods to characterize the composition of organic and inorganic fractions.
Which matrices are concerned by reverse engineering services?
Our reverse engineering services cover a wide range of matrices: aqueous solutions, powders, polymers, ceramics, metallic materials
Reverse engineering applications ?
Pharmaceutical : analysis of a drug's composition to identify its formulation and excipients.Cosmetics : identification of active ingredients and additives present in a product.Materials : study of the composition of polymers, ceramics or composites to optimize their properties.R&D : inspiration from existing products to create improved formulations.
The FILAB laboratory supports manufacturers in Reverse Engineering services
Why choose FILAB for Reverse Engineering services ?
Thanks to its experience in Reverse Engineering analysis and its state-of-the-art analytical facilities, the FILAB laboratory can assist you with your most complex Reverse Engineering analysis needs, whatever the nature of your sample.Reverse Engineering enables us to meet a wide range of needs, such as :
our services
Analyse and determine the composition of an unknown mixture
Check compliance with a Safety Data Sheet (SDS) or technical data sheet
Compare the composition of several products (double-sourcing or multi-sourcing)
Analyse and identify pollution or impurities
Our reverse engineering services involve a wide range of techniques, some of which are highly specialized :
our technical resources
Gas Chromatography-Mass Spectrometry (GC-MS)
X-ray diffraction (XRD)
Fourier transform infrared spectroscopy (IRTF)
Scanning Electron Microscopy(SEM)
Nuclear Magnetic Resonance (NMR)
Liquid chromatography coupled with mass spectrometry (LC-MS)
Inductively Coupled Plasma (ICP-MS)
Our technical resources
GPC (or SEC) analysis in a laboratory
Your needs : to characterize the size of your molecules using GPC or SEC
What do we mean by GPC/SEC?
Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a characterization technique used to determine the average molecular mass and distribution of molecular masses in a given sample. The dissolved sample is injected in a mobile phase (the eluent) into a column with controlled porosity (called the stationary phase).By using this type of chromatography with a series of detectors (IR, UV, RALS light diffusion, Viscometer), the GPC/SEC technique allows for the exact mass and size of molecules to be determined as well as the intrinsic viscosity of polymer structures to be measured.
How is GPC/SEC used ?
GPC/SEC is an analytical technique used to characterize a wide variety of polymers or other macromolecules found in mixtures.Used in quality control processes, when optimizing a procedure (ex. polymerization kinetics) or as part of an expertise (detection of pollutants or of contaminants…), this technique can meet the requirements of many industrialists in various fields : pharmaceuticals, plastics, chemistry, automobiles, foodstuffs, paints, lubricants, adhesives…
GPC polymer characterization
Gel permeation chromatography (GPC) is a useful technique for polymer characterization. Gel permeation chromatography can be used to analyze copolymer and oligomers. GPC is especially useful for determining molecular weight distributions of polymeric materials, and for monitoring degradation processes. To proceed with polymer characterization, Gel permeation chromatography (GPC) is a valuable technique. Considering its efficacy, gel permeation chromatography is extensively utilized across various industries for polymer analysis. From pharmaceuticals to food packaging, gel permeation chromatography provides an accurate and precise method for measuring the molecular weight distribution of polymer samples. Its ability to separate individual polymers within complex mixtures makes it an invaluable tool for researchers and manufacturers looking to better understand the properties and behavior of polymer materials. With its widespread use and versatility, gel permeation chromatography has become a standard tool for analyzing polymers across a broad range of industries.This technique is particularly important when examining the critical quality attributes of medical products such as bio-pharmaceuticals and vaccines, making gel permeation chromatography an indispensable tool in material science and biomedicine research.
Our solution : to characterize the structure of your macromolecules using GPC/SEC
Our services
From analysis to R&D, FILAB laboratory provides multidisciplinary expertise to fulfil different requests surrounding the GPC/SEC technique :
Inspection of the average molecular mass and distribution of masses in polymer-based materials and substances (Mn, Mw, Mp ?, dispersity index). The NF T 51-505 standard and the ISO 13885 set cover this service.
Structural characterization, namely branching analysis of macromolecular chains
Optimization of manufacturing procedures in order to improve synthesis, application and curing conditions
Defect expertise of thermoplastic parts linked to degradations of the polymeric fraction (shearing of the material leading to chain scission)
Deformulation/Reverse engineering of polymers to understand their physicochemical properties using techniques such as FTIR, TGA, GC-MS, Py-GC-MS, LC-MS…
Protein and polysaccharide characterization (sugars).
For this type of service, FILAB laboratory uses cutting edge analytical techniques such as Gel Permeation Chromatography (GPC/SEC) as well as Gas Chromatography coupled to a Mass Spectrometer after undergoing pyrolysis (Py-GCMS), Liquid Chromatography (LC-MSMS, HPLC…) followed up with other characterization techniques or even chemical analysis techniques (ICP-AES, ICP-MS, IC…).
Why FILAB ?
As an independent laboratory, with a team made up of experienced doctors and engineers, FILAB guarantees the reliability of its results, ensures a quick turnaround for requests and provides tailored support for its clients.
Notre FAQ
Why is GPC useful in polymer characterization?
By examining the size, shape, and charge of molecules, laboratories can better understand the properties of polymers, as well as their behavior in various conditions. The technique works by separating molecules with smaller molecules passing through a porous gel matrix more quickly than larger ones. GPC analysis is particularly useful for gaining insights into the structure of complex polymer materials, making it a valuable tool for researchers and manufacturers looking to optimize their materials for specific applications. This type of analysis is essential for creating new materials, improving existing ones, and optimizing production processes. The ability to fine tune polymer properties can have far-reaching implications, from improving medical devices to developing new and advanced technologies.
What industries are concerned with GPC analysis for gpc polymer characterization?
Gel permeation chromatography (GPC) analysis is used across various industries: petrochemicals, biopharmaceuticals, food and beverages, and polymers. Its versatility makes it indispensable for analyzing proteins and biomolecules in pharmaceutical development and quality control. GPC is also used in monitoring process-related changes in polymers, such as those found in adhesives and coatings. In the food industry, it facilitates the analysis of additives, stabilizers, and monitoring product shelf life. The petrochemical sector commonly relies on a GPC for petroleum analysis, fuel quality assessment, and oil spill detection. Moreover, GPC aids researchers in obtaining vital information on product quality within the polymer industry.
What are the advantages of gel permeation chromatography analysis?
GPC offers many advantages including its detection speed, reproducible results, high accuracy and precise size resolution. The technique also requires minimal sample preparation and allows the use of aqueous mobile phases, which can be advantageous when analyzing hydrophobic compounds or sensitive biomolecules. The technique is versatile enough to accommodate a variety of materials such as proteins, polymers and synthetic molecules.
Sectors of activity
Laboratory analysis of luxury goods
Your needs : to design luxury products using high quality materials.
Major brands, manufacturers and subcontractors in the luxury industry are all subject to common priorities and requirements : the pursuit of zero defects, higher production speed, better assembly reliability and the use of high-quality, durable materials.In order to meet these challenges specific to the luxury industry, inspection of the materials used is an essential step. Several factors can affect the life cycle of a luxury product :Defective raw materialsNon-conforming raw materialsAppearance of defects in the final productProblems in the suppliers' production process leading to delays in deliveryetc.For assistance with these industrial challenges you are searching for a reliable, independent laboratory with high added technical value.
Our solution : to offer tailored assistance to luxury industrialists by combining analytics, expertise and counselling on the design of their products.
FILAB laboratory being specialized in analysis and material characterization, has been assisting luxury industrialists in designing and inspecting their products using analytical techniques specific to their needs.Based on experience and its state-of-the-art analytical equipment, FILAB has a wide range of accurate and reliable tools at its disposal to provide the following services :
ANALYSIS
Chemical analysis (raw materials, finished products))
Packaging analysis
Precious metal analysis
REACH analysis
Material characterization : polymers, leather, metals, composite materials, ceramics…
Powder analysis
Surface analysis and coating thickness measurements
Nickel release test
EXPERTISE
Expert chemical analysis
Compatibility studies (container/contents interactions, extractables and leachables)
Pollutant identification using SEB or FTIR
Failure analysis : ruptures, corrosion, coloring and odor problems, etc.
Laboratory audit et analytical training
Deformulation services
R&D
Creation and transfer of analytical techniques
Research into substitutions for allergenic or toxic raw materials
Industrial project development
R&D assistance (Literature review, project management, choice of materials…)
Creation of an innovative product
OUR FACILITIES
Organic analysis : GCMS, Py-GCMS, LC-MSMS, GPC, NMR, FTIR
Mineral analysis : ICP, XRD, IC
Thermal analysis : TGA, DSC
Metallurgic analysis : ICP, SEM-FEG EDX, OES
Powder analysis : XRD, SEM-FEG EDX, BET
Surface analysis : SEM-FEG EDX, PES, TOF-SIMS
Our services
Analysis and characterization of composite materials in a laboratory
Your needs : to verify the quality and the performance of your composite materials as part of the designing process or to improve your products
As major players in the transportation, medical devices or sports equipment sectors, you are looking to optimize your manufacturing processes through the use of lighter and stronger composite materials.The diversity of composite material matrices makes them complex to analyze and requires periodic inspections to verify that they comply with relevant standards.For assistance in overcoming your manufacturing challenges or problems relating to product failures, you are looking for the support of a reliable and responsive laboratory specializing in the analysis and characterization of composite materials.
Our solution : to assist you in analyzing your composite materials and to characterize your problems relating to defects
With a team of experts in materials and an analytical fleet spread over 2100m2, FILAB laboratory provides analysis and characterization services for composite materials to assist you in overcoming your industrial challenges.From the designing process to the improvement of your composite material-based products, FILAB laboratory provides the following services:
Failure analysis of composite materials : aging, ruptures, non-compliances, apparition of deposits or of particulates…
Chemical analysis of the composition of a composite material
Composite material characterization : length, diameter, morphology…
Deformulation/Reverse engineering services
To achieve this, our laboratory has a Scanning Electron Microscope, coupled to an EDX probe, as well as numerous GC-MS and Py-GCMS machines to study the composition of composite materials (carbon fiber, fiberglass, ceramic...).Additionally, TGA thermogravimetric analysis coupled to FTIR will highlight the physicochemical properties of the composite material depending on temperature.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Sectors of activity
Tests and analysis for the aeronautics industry
Your needs: to design reliable and efficient aeronautical equipment
As major players or subcontractors in the aeronautics or space industries, the quality and reliability of your materials and equipment are paramount to ensure the security of the goods or the comfort the people being transported.Studying your materials and aeronautical equipment will allow you to increase the performance of your materials (lifespan, weight, noise output) and to optimize your costs (price of materials, maintenance) all while complying with environmental norms.These challenges prompt you to seek help from a responsive and reliable laboratory offering high added technical value.
Our solution : to assist our clients in the aeronautics industry with analysis and with the development of new materials
FILAB is an independent laboratory situated in the French city of Dijon and is made up of a team of 63 people, including doctors and engineers.FILAB has been approved by SAFRAN for chemical analysis of metal alloys or of mineral products relating to aeronautics.With an analytical fleet spread over 2100m² and extensive experience in assisting as part of projects in the aeronautics or space industry FILAB can offer the following services :
ANALYSIS
Chemical analysis : fluids, industrial oils, resins…
Metallic alloy inspection
Surface analysis and coating thickness measurement
Determination of trace amounts and impurities (heavy metals)
Analysis in relation to a regulatory compliance study (AS9100 standard)
Material characterization : polymers, composites, metallurgical analysis
Powder analysis
Thermal analysis
Analysis of leachable volatile organic compounds using GC-MS and HS-GCMS
EXPERTISE
Accelerated aging tests
Deformulation/Reverse engineering services
Failure analysis : fissures, contaminant or particle analysis, adhesive problems, corrosion, metallographic examination, weld analysis…
Assistance in getting cleaning procedures validated
Identification of unknown pollutants
Regulatory compliance testing (container/contents interactions, extractable and leachable substances)
Analytical training and laboratory audits
R&D
Creation and transfer of new analytical methods
Research into substitutions for carcinogens
Literature reviews
Development of a new chemical formula or of a new material
OUR FACILITIES
Organic analysis : GCMS, Py-GCMS, LC-MSMS, GPC, NMR, FTIR
Thermal analysis : TGA, DSC
Powder analysis : XRD, FEG-SEM-EDS, BET
Mineral analysis : ICP analysis, XRD analysis, IC
Metallurgical analysis : ICP, FEG-SEM-EDS, SEO
Surface analysis : FEG-SEM-EDS, PES, TOF-SIMS
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Chemical analysis for paint and varnish testing in a laboratory
Your needs : to do a paint or varnish testing, to characterize a defect found in a batch of industrial paint or varnish
What is industrial paint made of ?
Paint or varnish is liquid mixture allowing for the surfaces of industrial products to be protected, dyed or improved. Paint is generally made up of 3 main components :- The pigment (dye and opacity)- The binder, giving the paint its consistency and transparency- The solvent, allowing for easier application as a liquid. Once the paint is applied the solvent evaporates and the paint hardens.Other ingredients can be added to strengthen the paint’s resistance to outside influencesPaint is generally applied in multiple layers on a smooth, clean surface.
Why analyze a paint or vanish ?
The chemical analysis of a paint or varnish can have different goals :- to verify that the product is compliant with relevant standards- to analyze the chemical composition of a paint or varnish- to reverse engineer a varnish- to study a defect or product failure after paint or varnish was appliedAnalysis and testing of paint or varnish can in fact be needed after a defect is detected on a product’s surface (stain, adhesive problems, scales, color change…). After the identification process, analysis allow for the origin of the defect to be characterized.The application of paint or varnish must abide by a scope statement in line with standards and regulations or industrial requirements, with particular attention given to :- The quality of raw materials being used to make the paint- The desired characteristics of the finished product- The quality of the coating faced with different outside constraintsAssistance from an analytical laboratory will allow you to ensure that the paints and varnishes you use are in compliance with relevant standards.
Our solution : to analyze the quality of your paints and varnishes and to provide you with tailored solutions to optimize their characteristics
Our services
Relying on extensive experience in analytical chemistry, FILAB laboratory can provide analysis and testing services for your industrial paints and varnishes, adapted to your requests :Conformity analysis of your paints and varnishesPigment analysisImpurity and contaminant detectionAdvice in the choice of paintsVarnish, paint and polymer stress testingLead and heavy metal analysis of paintsVOC analysis (Volatile Organic Compounds)Deformulation/Reverse engineering services These chemical analysis are performed using different techniques :Gas chromatography coupled with mass spectrometry (GC-MS)Scanning electron microscopy (SEM-FEG-EDX)Optical microscopyThermal analysis (DSC)Infrared spectrometry (FTIR)ICP-AES and ICP-MSMS spectrometry
Why FILAB ?
As an independent laboratory, with a team made up of experienced doctors and engineers, FILAB guarantees the reliability of its results, ensures a quick turnaround of requests and provides tailored support for its clients.For more information about our analysis of paints and varnishes, feel free to contact us
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Sectors of activity
Laboratory analysis of active ingredients for the pharmaceutical industry
Your needs : to analyze and determine the active ingredient contents in your products to meet regulatory requirements
An active pharmaceutical ingredient (API), also called active substance are the substances in medication which given them their biological and therapeutic properties. From natural (mineral, animal or vegetal) or synthetic origins, active ingredients are completed by excipients which give the medication its flavor, shape or even color.Just like excipients, active pharmaceutical ingredients (APIs) are subject to important regulatory constraints in order to avoid any risk of toxicity for the consumer. For this reason, pharmaceutical companies and industrial suppliers must regularly inspect the quality of their active ingredients in order to remain in line with regulatory changes.
Our solution : to provide you with our expertise and our technical facilities to analyze the active ingredients of your pharmaceutical products
As an independent laboratory situated in Dijon, France, FILAB has been active in the pharmaceutical industry for over 30 years by performing compliance checks and inspecting raw materials used in medication.From the designing process to production, all the way to the product being put on the market, FILAB can assist you in properly carrying out your industrial projects, abiding by security standards. These are a few examples :ICP determination of active ingredient contentsCharacterization of active ingredients using GC-MS, NMR, LC-MS/MS…Detection of elemental impurities in pharmaceutical products in accordance with the USP 233 standard (ICH Q3D)Stability and compatibility studiesDevelopment of analytical methods of determination in accordance with relevant referencesDeformulation/reverse engineering of finished productsBy guaranteeing a quick turnaround for your requests, FILAB supports pharmaceutical industrialists with their needs for complex chemical analysis as well as with their R&D projects (literature review, scope statements, substitution research, synthesis…)
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Analytical laboratory
Your needs: to analyze and inspect the chemical substances which make up your raw materials and finished products
Why conduct chemical analysis?
The rise of international competition and complication of regulations incite industrialists to optimize the performance of their products by better understanding the products physicochemical properties. To achieve this, analytical chemistry can be used to obtain quantitative (concentration and determination of compounds) or qualitative (overall chemical nature of a compound) analysis of the product.As part of quality control, of regulatory compliance or following the discovery of a product failure, analytical chemistry plays an essential role in all sectors of industry.Our laboratory, being specialized in chemical analysis and equipped with state-of-the-art analytical techniques, is here to assist you in your endeavors.
Our solution: to assist industrialists in overcoming their challenges by providing chemical analysis with high added value
Thanks to its highly trained team the FILAB laboratory can offer a multitude of analytical services to inspect your raw materials or finished products.
OUR ANALYTICAL SERVICES
Custom chemical analysis
REACH analysis
Elemental analysis
Chemical analysis of polymers, composite materials, metallic materials and ceramics
Heavy metal analysis
Biocompatibility analysis in accordance with ISO 10993
Bisphenol A analysis
Analysis of cleaning product residue on medical devices THC/TOC
Deformulation services
ISO 17025 accredited laboratory
Raw material analysis (impurity detection)
Industrial analysis
Contamination or pollutant analysis
Chemical analysis following a product failure
Surface treatment bath analysis
Analysis of phthalates and of DEHP
Residual solvent analysis
Granulometric analysis
Development and validation of new analytical techniques
Paint/Varnish analysis
OUR FACILITIES
GC-MS, HS-GCMS (Gas chromatography)
ICP-AES, ICP-MS
DSC
IC (Ionic chromatography)
HPLC-MS/MS, HPLC-DAD (Liquid Chromatography)
FTIR (Infrared spectroscopy)
UV-Vis spectrometry
SEM-EDX (scanning electron microscopy)
With three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Laboratory analysis of additives
Your needs : to analyze the different properties and the performance of an additive by studying its composition
An additive is a chemical substance added to the composition of a material or product to improve its final properties. It is important to distinguish food additives (dyes, preservatives, sweeteners) from polymer additives (heat resistance, elasticity, plasticity…) and from additives put into industrial paints and varnishes.As part of the development or optimization processes of a product, of changes in regulations, or following a product failure, you are looking to characterize and determine the additive contents of your products with support from a specialized laboratory.
Our solution : to provide you with our analytical equipment and the expertise of our engineers for your analysis and for the optimization of your industrial additives
Thanks to the fact that our facilities complement each other well and our dual expertise in chemistry and materials science, FILAB can perform physicochemical analysis to characterize the presence of additive in your industrial materials :Determination of the additive contents of a productInspection of the composition of a product compared to its SDSAccelerated aging tests on products containing additivesProduct reverse engineering to determine the presence of additivesAnalytical development and validationTo provide these services, FILAB laboratory uses a wide range of analytical techniques :DSC or ATG thermal analysisChromatographical analysis (GC-MS or HPLC) to identify volatile additivesSpectrometric analysis (FTIR, ICP-MS and ICP-AES) to measure the presence of an additive in a polymerWith three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Sectors of activity
API testing in a laboratory
Your needs : to verify that your APIs comply with relevant standards and regulations
APIs, or active pharmaceutical ingredients, are substances contained in drugs that are responsible for the health benefits they bring to the patient.Subject to numerous international regulations, including ICH Q7, the quality and safety of APIs is a primary requirement for any pharmaceutical manufacturer to get their product to market.In light of this, the use of a specialized inspection laboratory guarantees compliance with standards, efficiency and safety of your pharmaceutical products.
Our solution : to provide you with our methods and our technical facilities to be able to characterize your active pharmaceutical ingredients
For 30 years, the laboratory has been assisting manufacturers in the pharmaceutical industry with analysis, inspections and the development of reliable and compliant products.From analysis to project management, FILAB provides the following services :API analysis using GC-MS, NMR or LC-MSMSInspections of finished productsAPI compatibility and stability testingDetection of elemental impurities in pharmaceutical products in accordance with USP 233Development of new analytical procedures for determining API contents in accordance with relevant standardsDeformulation/Reverse engineering of finished productsFILAB provides direct technical support to answer all your questions and to guarantee a quick turnaround of your requests.
Our services
Laboratory analysis of biological medicine
Your needs: to ensure a high level of quality for your biological medicine in accordance with relevant pharmaceutical standards
Biological medicines are medications with active ingredients taken from living sources. They differ from conventional medications as their active ingredients are not chemically synthesized.Biological medicines encompass vaccines, therapeutic proteins and monoclonal antibodies which are often administered in the form of injectable drugs.These biological medicines are subject to the same types of stringent regulations as conventional medicines. Many chemical analysis must therefore be carried out on these substances.Compliance of biological medicines is critical for them to be able to go to market and is essential for their life cycle.A poorly aging product, the presence of impurities, interactions between active ingredients and excipients… These scenarios all hinder a biological medicine’s chances of going to market and can cause them to be called back.To overcome these technical challenges, you are looking to cooperate with a reliable and reactive analytical laboratory.
Our solution: to assist you in expertly analyzing your biological medicine and monitoring its quality
FILAB offers its high level of skill and its advanced technical know-how along with a cutting-edge analytical fleet to pharmaceutical industrialists by providing services fulfilling various compliance requirements. FILAB is the only laboratory in France to be ISO 17025 accredited (www.cofrac.fr accreditation n°1-1793) for carrying out analysis of elemental impurities found in pharmaceutical matrices.From analysis to R&D, FILAB laboratory is able to provide its expertise to fulfil various types of requests relating to biological medicines :Chemical analysis of biological medicines using GC-MS, LC-MS, ICP…Detection of elemental impurities (ICH Q3D)Particulate analysis (troubleshooting) using SEM-EDX, FTIR, LC-MS/MS…Reverse engineering of biological medicinesE&L testingAnalytical developmentValidation of methods in accordance with ICH Q2Analysis of residual solvents found in pharmaceuticals in accordance with the ICH Q3D guidelineNitrosamine analysis For more information about our analytical services relating to biological medicine, feel free to contact us via email at contact@filab.fr or over the phone by calling +33 (0)3 80 52 32 05. You can also request a free quote online here.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Laboratory analysis of counterfeit goods
Your needs : to ensure the authenticity of a product or formulation before starting production or before putting a product on the market
What are counterfeit goods ?
A counterfeit item is a reproduction or imitation of a chemical substance or formulation. In an industrial context, counterfeit goods are produced to create a sense of confusion between the characteristics of the original product (packaging, container, formulation…) and the imitation products (chemical formulation, raw material…)Counterfeit product affects many industrial fields, such as pharmaceuticals (over 10% of medications in circulation are counterfeits), cosmetics, luxury goods and the production of chemicals as a whole. Counterfeit goods pose a major risk to consumers as they can trigger allergies or have adverse side effects.
How is counterfeit identified and subsequently analyzed ?
From the reception of raw materials to the production line, all the way to the finished product, the increasing amount of counterfeit goods is leading companies to strengthen their expertise of the composition and traceability of their products.To verify that a product is actually what it is labeled to be, support from an analytical laboratory will make it possible to detect fraudulent or toxic substances, to quantify them and to file a report concluding on whether or not the product is compliant.
Our solution : to lead a complete analytical investigation of your products by studying their chemical composition
Our services
Equipped with diverse and cutting-edge analytical facilities, FILAB laboratory is able to verify that your industrial products comply with relevant standards and can detect counterfeit compounds to prove that a product is an imitation.Each compound suspected of being a counterfeit is subjected to various tests conducted by our experts :Chemical composition analysisTrace residue analysis of toxic substancesPackaging expertiseAnalysis of container/contents interactions and of migration phenomenaSurface analysis using Scanning Electron MicroscopyChromatographic composition analysis (GC-MS or LC-MS/MS)Impurity detection using NMR or ICPIdentification of prohibited organic compoundsProduct reverse engineeringThe centralization and combination of these tools will make it possible to quickly and precisely overcome industrial challenges relating to counterfeit goods of any kind.
Why FILAB ?
As an independent laboratory with a team made up of highly qualified personnel, FILAB guarantees the reliability of its results, a quick turnaround for requests and tailored support for clients.
Our services
Laboratory analysis and determination of D4 and D5 siloxane content
The analysis of D4 and D5 siloxanes at FILAB is important for industries utilizing these chemicals, especially in cosmetic products. Employing advanced gas chromatography and other analytical techniques, FILAB's services ensure that products comply with environmental and safety standards. This chemical analysis process is vital for confirming that siloxane levels in products are within legal and safe limits, supporting both product safety and environmental sustainability.
Your needs: to monitor the use of D4 and D5 siloxane in your production processes
What do we mean by Siloxanes?
The name Siloxane is derived from Silicon, Oxygen and alkane. They are a family of chemical substances composed of primarily of silicon. Usually found in cosmetic products, (makeup, crème, deodorant…) and in cleaning as a whole, in paint, etc. They are used for they particular chemical properties: they are odorless, colorless, non-greasy, easy to apply and dry rapidly.This family encompasses multiple categories of substances: Cyclotetrasiloxanes (D4), Cyclopentasiloxanes (D5) and Cyclohexasiloxanes (D6). The term “silicone” can also be used to refer to siloxanes.
Why analyze siloxanes?
Found in some household products, humans can de exposed to siloxanes through skin contact or by inhalation. D4 siloxanes have been classified as endocrine disruptors by the European Union due to their suspected toxicity to the human reproductive system. However, risks linked to the use of cosmetic products containing D4 siloxanes has not yet been proven. Regarding D5 siloxanes, regulatory authorities consider its use to be risk free.Ecological concerns have been raised surrounding the use of these two substances; D4 and D5 siloxanes are suspected to be toxic to aquatic life due to the fact that they are not biodegradable in water or living tissue.The monitoring of scientific advances relating to the use of siloxanes and their impact on human and environmental health is an important topic in the cosmetics industry. Therefore, support from a specialized laboratory will allow you to adapt your production procedures to stay in line with changes in regulations.
Our solution: to reliably analyze and quantify the presence of D4 and D5 siloxane in your finished products to asses the risk they pose
Our analytical services for D4/D5 siloxanes
Thanks to the know-how of its team and its cutting-edge analytical fleet, FILAB laboratory is able to assist companies with analysis of D4 and D5 siloxanes and in verifying that their products comply with standards:Determination and analysis of siloxane contents in your productsAnalytical development and validation of methods for determining content in accordance with relevant ISO standardsR&S assistance: product substitution, reverse engineering, literature review…D4 and D5 siloxanes are analyzable using gas chromatography (GC-MS) due to their volatility. Being organic compounds, it is possible to determine their structure using Nuclear Magnetic Resonance (NMR).
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
What are the restrictions regarding D4 et D5 siloxane content?
In Europe, the use of D4 siloxane (octamethylcyclotetrasiloxane) and D5 siloxane (decamethylcyclopentasiloxane) in wash-off cosmetic products is restricted by the European Chemicals Agency (ECHA) due to their potential environmental impact. The restriction applies to leave-on products that are intended to stay on the skin or hair, as well as wash-off products that are applied to areas of the body where they may be washed off and enter the environment. However, the restrictions do not apply to rinse-off products where the product is immediately rinsed off the body, such as shampoos and soaps. The restrictions are based on the potential for these compounds to bioaccumulate in aquatic organisms and their tendency to persist in the environment. The use of D4 siloxane and D5 siloxane in other consumer products, such as adhesives, sealants, and coatings, is not restricted in Europe, although their use is subject to evaluation and may be restricted in the future if they are found to pose a risk to human health or the environment.
What are the risks if you do not perform D4 and D5 siloxane analysis?
The fines that companies could face for violating regulations regarding siloxanes in cosmetics and other products can vary depending on the specific country and regulations involved. In Europe, the fines may be imposed by the national authorities responsible for enforcing cosmetic regulations, such as the European Chemicals Agency (ECHA).If a company is found to be in violation of these regulations about siloxane analysis, they may face fines, as well as other legal consequences like product recalls or injunctions. The fines can vary widely depending on the severity of the violation and the specific country involved.For example, in France, violations of the country's cosmetic regulations can result in fines of up to €150,000 and two years of imprisonment. In the UK, fines for violating cosmetic regulations can reach up to £20,000 per offense.It's important to note that the fines are not the only potential legal consequence for companies. If a consumer is harmed by a product that contains excessive levels of D4/D5 siloxanes or other harmful substances, the company could also face lawsuits, damages, and reputational harm.To avoid fines and other legal consequences, it's crucial for companies to comply with all relevant regulations and conduct proper testing and siloxane analysis of their products. To make sure your products comply with the regulations of your country, contact Filab to advise you and perform your analysis.
How to perform siloxane analysis?
Siloxane analysis can be performed using a number of different analytical techniques, depending on the specific application and desired level of sensitivity. Here are some commonly used methods: Gas chromatography-mass spectrometry (GC-MS): This is a widely used method for analyzing D4 and D5 siloxanes in environmental and personal care products. It involves separating the siloxanes from the sample matrix using gas chromatography, and then identifying and quantifying them using mass spectrometry. Liquid chromatography-mass spectrometry (LC-MS): This method is similar to GC-MS, but uses liquid chromatography instead of gas chromatography to separate the siloxanes from the sample matrix. It is often used for analyzing siloxanes in biological samples, such as blood or urine. Fourier transform infrared spectroscopy (FTIR): This method measures the chemical bonds between atoms in a sample, and is often used for analyzing siloxanes in silicone-based materials, such as medical devices or industrial coatings. Nuclear magnetic resonance (NMR) spectroscopy: This method uses the magnetic properties of atomic nuclei to identify and quantify siloxanes in a sample. It is often used for analyzing complex mixtures of siloxanes, such as those found in silicone oils or greases. Solid-phase microextraction (SPME): This method involves extracting siloxanes from a sample matrix using a small, coated fiber, which is then analyzed using GC-MS. It is often used for analyzing volatile organic compounds in air or water samples.Each of these methods has its own advantages and limitations, and the choice of method will depend on the specific application and requirements of the analysis.
What are the specificities of D5 and D4 siloxane in cosmetics?
Siloxanes are commonly used in cosmetics due to their unique properties, but there are concerns about their potential impact on human health and the environment. Here are some specificities of siloxanes in cosmetics and why analyzing their content within products is important: Potential toxicity: Some research has suggested that certain siloxanes, like D4 and D5, may have endocrine-disrupting effects and could potentially be harmful to human health. This is a concern for products that are applied directly to the skin or mucous membranes, such as lipsticks or vaginal creams. Environmental impact: Siloxanes can have a negative impact on the environment, particularly when they are released into waterways through the use of wash-off products. Siloxanes like D4 and D5 have been found to bioaccumulate in aquatic organisms and can persist in the environment for long periods of time, which can have cascading effects on ecosystems. Regulatory restrictions: Due to these concerns, siloxanes like D4 and D5 are subject to regulatory restrictions in some regions, particularly in Europe. Analyzing the content of these compounds within cosmetic products can help ensure compliance with these regulations and provide consumers with information about the safety and environmental impact of the products they use. Product formulation: Analyzing the content of siloxanes within cosmetic products is also important for product formulation. Different types of siloxanes have different properties and may be more or less suitable for different types of products. Analyzing the content of siloxanes within a product can help ensure that it performs as intended and meets consumer expectations. Analyzing the content of siloxanes within cosmetic products is important for ensuring the safety and environmental impact of these products, as well as for product formulation and compliance with regulatory requirements.
Sectors of activity
Excipient analysis laboratory for the pharmaceutical industry
Your needs : to reliably analyze excipients found in your pharmaceutical products to meet regulatory requirements
Used in the pharmaceutical and cosmetics industries, an excipient is the name given to any substance present in a product that is not the active ingredient. While not having intrinsic therapeutic properties, excipients will give the final product new properties such as greater stability, better taste, a more desirable color, a different shape, etc.
To avoid any risks of chemical interactions or even toxic reactions, excipients are subject to stringent regulatory constraints especially as some of them can trigger allergies or intolerances (lactose, aspartame, formaldehyde, mannitol, wheat starch)
Pharmaceutical laboratories and excipient suppliers must verify that their excipients comply with relevant standards (detection of impurities) as well as evaluating their compatibility with the active ingredient, packaging and final use of the product. To achieve this, support from a laboratory specialized in analyzing active pharmaceutical ingredients will allow you to carry out regular inspections to ensure that your excipients stay in line with changing regulations.
Our solution : to provide you with the tools and experience needed to quickly and reliably evaluate your excipients
For over 30 years, FILAB has had the experience and specific analytical fleet needed to be able to assist pharmaceutical companies in analyzing their substances and excipients, all while providing tailored support.
From analysis to analytical development, FILAB can support your industrial projects while abiding by safety standards by providing the following services :
Excipient characterization using GC-MS, LC-MS/MS, NMR…
ICP-AES and ICP-MS screening and determination
Particulate or contaminant analysis of excipients
Detection of elemental impurities in excipients in accordance with the USP 233 (ICH Q3D)
Compatibility testing between active ingredients and excipients
Analytical development and validation of methods for determining excipient contents in accordance with relevant standards (ICH, USP, EP, ISO...)
Reverse engineering of finished products
Our services
Chemical analysis of industrial adhesives in a laboratory
Your needs : to analyze an industrial adhesive or to characterize a defect found in a regular or industrial adhesive
What is an industrial adhesive used for ?
An adhesive is a bonding agent used in industrial manufacturing processes to assemble different metallic or plastic parts together. The efficiency of an adhesive is directly linked to its composition, it must therefore meet certain criteria :Resistance to traction and movementResistance to outside constraints (joint seals) over timeCure time optimization based on industrial processes
Why analyze an adhesive or an industrial adhesive ?
Chemical analysis of an adhesive can be useful for various reasons :To verify that an adhesive is compliant with safety data sheetsTo analyze its chemical compositionTo study its behavior in any given conditionsTo study a defect or product failure following the application of an adhesiveAnalysis and characterization of an adhesive can be needed after a defect is found in the way a product is assembled (adhesive problems, disbonding, trace residues…) Analytical methods allow for the origin of the defect to be characterized and to determine whether it is due to the composition of the adhesive or the state of the product’s surface.Assistance from an analytical laboratory will allow you to ensure that your products are in compliance with relevant standards.
Our solution : to analyze the quality of your adhesives and to provide you with tailored solutions to optimize their characteristics
Our adhesive analysis services
Relying on extensive experience in analytical chemistry, FILAB laboratory can provide analysis and characterization services for adhesives, adapted to your requests :Conformity analysis of the adhesive’s compositionImpurity and contaminant detection in your adhesivesAdvice in the choice of adhesive (double sourcing, stress testing)Deformulation/Reverse engineering servicesCuring time optimization using DSCDisbonding expertise Coupled with surface analysis, our adhesive analysis services are carried out using various techniques :Gas chromatography coupled with mass spectrometry (GC-MS)Scanning electron microscopy (SEM-FEG-EDX)Optical microscopyThermal analysis (DSC)Infrared spectrometry (FTIR)ICP-AES and ICP-MSMS spectrometry
Why FILAB ?
As an independent laboratory, with a team made up of experienced doctors and engineers, FILAB guarantees the reliability of its results, ensures a quick turnover for requests and provides tailored support for its clients.
Sectors of activity
Laboratory analysis of glass and fiber glass
Your needs : to design glass materials or bottles that are both of high quality and safe
Glass is a material with many different applications, which makes it difficult for manufacturers or subcontractors to analyze and use. Studying the characteristics of flat glass, hollow glass, fiberglass or clear glass allows companies to better control their composition, their durability and their practical use.As major players in the glass industry you face a variety of challenges relating to the quality of the materials being used, product failures, or even problems with container/contents interactions.Inspections and chemical analysis before and after marketing will contribute to the quality of the finished product.
Our solution : to assess the conformity of a glass or fiber glass sample and to characterize any failures using specific analytical techniques
FILAB, being specialized in analytical chemistry and material characterization assists glass manufacturers in analyzing, inspecting and assessing their products. Organic and inorganic chemistry as well as material science are all areas of expertise are that sought after by the glass industry and brought together in our laboratory guaranteeing responsiveness and high-quality results.FILAB can offer the following services :
ANALYSIS
Custom chemical analysis using ICP-MS and ICP-AES
Surface characterization and coating thickness measurements
Crystallinity analysis
REACH Analysis
Material characterization : physicochemical analysis, thermal and morphological characteristics
Granulometric analysis
Laboratory audit and team training
EXPERTISE
Expert chemical analysis
Deformulation services
Failure analysis : fissures, particulate contamination, adhesive failure, corrosion, metallographic examination, weld analysis
Deposit or pollutant identification
Stability analysis
Laboratory audit and analytical training
R&D
Literature reviews
Research into substitutions for raw materials
Development of new industrial procedures
Creation and transfer of analytical techniques
Creation of new substances
OUR FACILITIES
Organic analysis : GCMS, Py-GCMS, LC-MSMS, GPC, NMR, FTIR
Thermal analysis : TGA, DSC
Powder analysis : XRD, SEM-FEG EDX, BET
Mineral analysis : ICP, XRD, IC
Metallurgical analysis : ICP, SEM-FEG EDX, OES
Surface analysis : SEM-FEG EDX, PES, ToF-SIMS
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Laboratory analysis of industrial resin
Your resin : to analyze the properties and performances of a resin by studying its composition.
A resin is a polymer used as a precursor in the production of plastics, textiles, paints/varnishes and adhesives. They are used for their thermosetting, mechanical or esthetic propertiesConfronted with a product failure or a change of suppliers, you are looking to characterize the composition and properties of an industrial resin in order to evaluate its performance according to the final use of your product. To achieve this, you wish to carry out chemical analysis with the support of a specialized laboratory.
Our solution : to provide you with our analytical equipment and the expertise of our engineers for the analysis and the optimization of your industrial resins
Thanks to the fact that our facilities complement each other well and our dual expertise in chemistry and materials science, FILAB can perform physicochemical analysis to determine the chemical composition of a resin and polymers in general :Chemical analysis of varnish or resinDetermination of the different compounds making up a resinSurface characterization of a resinPolymer analysisAccelerated aging tests on resinsProduct reverse engineering to determine its compositionDSC curing analysisTGA and TGA-FTIR analysisAnalytical development and validationWith three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Laboratory analysis and determination of isopropanol contents
Your needs : to determine the isopropyl alcohol (isopropanol) contents in your products in accordance with relevant standards
Isopropanol or isopropyl alcohol is a secondary alcohol and is usually a colorless, volatile and flammable liquid. Isopropyl alcohol is used in industry as a degreasing agent, a disinfectant, a dissolvent or as an additive in gasoline. Isopropanol can therefore be found in numerous products such as paints and varnishes, adhesives, perfumes, makeup removers… Isopropanol is toxic to humans. If ingested, absorbed by the respiratory system or through skin contact, isopropanol can cause irritations, rashes and can even damage the central nervous system.Subject to very many regulations due to its toxicity, isopropanol requires constant monitoring to comply with standards.
Our solution : to provide you with cutting-edge analytical tools for determining the isopropanol contents in your products
As an independent laboratory, FILAB has been assisting industrialists for over 30 years in overcoming their challenges relating to isopropanol. To fulfil your needs, FILAB can provide the following services :
OUR SERVICES
Determination of isopropanol contents using HS-GC-MS or GC-MS
R&D support : deformulation/reverse engineering, literature reviews…
Analytical development and validation of techniques for determining isopropanol contents in your matrices
Sectors of activity
Laboratory analysis of medications
Your needs : to verify that your medications comply with relevant standards
As manufacturers producing medication for human or animal consumption (generic drugs, injectable solutions…) you need fulfil many quality requirements surrounding your product. These requirements affect the process of bringing a product to market just as much as the other parts of a medication’s lifecycle. Stringent regulations require you to carry out numerous quality inspections in accordance with the standards stated in the European Pharmacopeia.Non-compliance in medication (presence of impurities, active ingredient/excipient interactions) can cause a product to not receive the necessary authorization to go to market or can cause it to be taken off the market.To overcome these technical challenges, you are looking to cooperate with a reliable and reactive analytical laboratory.
Our solution : to assist medication producers by providing analyzes and compliance testing for their products
FILAB offers its high level of technical skill and cutting-edge analytical fleet to pharmaceutical industrialists, providing services meeting their criteria all while abiding by regulatory standards relating to galenic medications.To precisely and reliably solve overcome these challenges, FILAB offers tailored support with the analysis of your medications :Chemical analysis of your medications using GC-MS, LC-MS, ICP…Detection of elemental impurities (ICH Q3D) using ICP-MS and ICP-AESParticulate analysis (troubleshooting) using SEM-EDX, FTIR, LC-MS/MS…Reverse engineering of medicationsE&L testingFor more information about our analytical services for your pharmaceutical products (medications, packaging, injectable solution…), feel free to contact us via email at contact@filab.fr, over the phone by calling +33 (0)3 80 52 32 05 or you can request a free quote online here.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Laboratory analysis and determination of methanol contents
Your needs : to determine the methanol contents in your products to comply with established limits
Methyl alcohol or methanol is a colorless, volatile and flammable liquid. Methanol is used as a solvent (in paints and dyes or to dissolve grease, plastics or mineral salts) as an antifreeze (in coolant) or even as a fuel. Methanol is a raw material used to make plastics or synthetic resins.Methanol, just like ethanol, is toxic to humans. This is why its use and its presence in various products are subject to numerous regulations. Support from a qualified laboratory will allow you to analyze and determine the methanol contents present in your products to comply with relevant standards.
Our solution : to provide you with our analytical facilities to determine the methanol contents of your products in accordance with relevant standards
FILAB laboratory is equipped with a cutting-edge analytical fleet and is made up of a team of qualified experts with extensive experience in handling methanol-based products. To determine the methanol contents of your products, FILAB provides various reliable services :Determination of methanol contents using HS-GC-MS or GC-MSAnalytical development and validation of methods for determining methanol contentsR&D support : deformulation/reverse engineering, literature reviews…Determination of the methanol contents in cosmetic products (perfumes, cremes, gels…)
Our services
Laboratory analysis of PEEK polymers
Your needs : to verify that the performances of your PEEK polymers comply with relevant standards using cutting edge techniques
The use of plastics has become increasingly widespread in industrial fields. Among them, polyether ether ketones (or PEEKs) are high performance materials, chosen for their thermal stability and chemical resistance.PEEKs are used in many industrial applications such as aeronautics, medical devices, energy production...
Our solution : to provide reliable and responsive analysis services as part of the inspection of PEEK materials
With extensive experience in material analysis and characterization, FILAB laboratory can assist you in understanding the behavior of your PEEK substances and in finding appropriate solutions in the event of a failure.Thanks to an analytical fleet spread over 2100 m², FILAB laboratory offers several analytical services for PEEK substances :- Determination of the nature of polymers using GC-MS, FTIR, TGA or DSC- Deformulation/Reverse engineering of polymers- Determination of additives in PEEK products- Failure analysis of PEEK products- Conformity inspection as part of REACH analysis- Thermal and thermogravimetric analysis- Development of analysis procedures.As an independent laboratory located in Dijon, with our team of 100 people, ensure efficient results and quick turnaround for your requests.
Our services
Nitrosamines : the first deadlines for marketing authorization holders are close
At the request of the EMA (European Medicines Agency), Marketing Authorization Holders (MAH) are required to monitor the presence of nitrosamines in their medicines, by presenting, among other things, an assessment of the potential contamination risks. This evaluation must be done before March 26th 2020 in France and before May 15th 2020 in Switzerland.
Nitrosamines classified as “dangerous” found in certain medicines
Chemical reactions between amines, ammonia salts and nitrites, cross contaminations, the use of contaminated ingredients, packaging, cleaning protocols… potential sources of nitrosamines are numerous and widespread.Classified as, or suspected to be carcinogens, European and American markets have more than once had to carry out mass recalls of medicines designed for human consumption containing trace amounts of nitrosaminesIn 2018, the EMA lead investigations and information campaigns with the support of competent authorities to reduce the risk of nitrosamines being present in pharmaceutical products. In September of 2019, the EMA and the CMD published a document titled “Information on nitrosamines for marketing authorization holders” detailing the importance of evaluating the risk of nitrosamine contaminations during production processes.New requirements are also added to the responsibilities of MAHs for the inspection of impurities as well as of active ingredients and some other components (dyes, solvents, catalysts…).
Steps to follow :
In this regard, measures must be implemented quickly, following these steps :Step 1 : Risk assessment and management in accordance with ICH Q9 guidelinesClassification of APIs and medicines by priority (daily dose, treatment duration, route of administration, patient profile…)Determination of the risk of potential nitrosamine contaminations depending on the production processDetailed conclusions on the presence of absence of a riskThe EMA has asked for a report on these evaluations before March 26th 2020SWISSMEDIC set their deadline to May 15th 2020.Step 2 : Confirmation testsIf a potential risk has been identified, analysis must be carried out in the order set in the first step, sorting by priority and in accordance with the following requirements :The analytical methods must be validatedLoQ must be under 30 ppbThe analysis being carried out must comply with GMPAuthorities will have to be informed if the results reveal that nitrosamines are present, whatever the amount may be.Step 3 : Implementation of corrective procedures Corrective procedures (a change in the production process, a change in the supplier’s scope statement…) will need to be implemented before September 26 2022, 3 years after the EMA published their document and November 15th 2021, 2 years after SWISSMEDIC published theirs.
FILAB : providing specific services for evaluating the risks of nitrosamine contamination
To assist producers in developing and controlling the quality of their product, while complying with the changes in regulations mentioned above, FILAB laboratory provides its cutting-edge analytical fleet making it possible to detect and quantify nitrosamines (NDMA, NDEA, NDMEA, NDPA…) and their precursors in samples.The limits of detection for determining nitrosamine contents vary from 1 to 10 µk/kg depending on the nitrosamine and matrix being used.It is important to note that FILAB uses many methods which have been validated by COFRAC, a member of ILAC, for determining nitrosamine contents using LC-MS/MS. FILAB also provides other services that can fulfil your needs relating to nitrosamines :Development, validation and transfer of methods for determining nitrosamine contentsDeformulation/Reverse engineering (additives, adjuvants…)REACH analysisCompatibility and stability testingNanomaterial characterizationTroubleshootingElemental impurity analysis (ICH Q3D)
Ask a quotation
Our services
Thermal analysis on polymers
How to better monitor and analyze the thermal characteristics of your polymers?
Thermal analysis of a polymer makes it possible to characterize its behavior when subjected to thermal constraints (high heat).This step is used to be able to anticipate the performance or potential degradation of a polymer in specific thermal conditions throughout its lifecycle (from creation to its final use).
How can FILAB assist you with your need to carry out thermal analysis on your polymers?
For over 30 years, FILAB laboratory has had the experience and specific analytical fleet needed to be able to fulfil requests for thermal analysis for many industrial clients. Polymers and composites alike, FILAB is able to support companies in characterizing their materials through reliable and personalized thermal analysis and by helping interpret their results.FILAB uses various thermal analysis techniques, making it possible to highlight the physicochemical specificities of a polymer depending on outside temperature:Pyrolysis analysis paired with GC-MS (Py-GC-MS)Thermogravimetric analysis (TGA, TGA paired with FTIR)Differential Scanning Calorimetry (DSC)Gas Chromatography (GC-MS)Thermal Desorption analysis (Thermal Desorption Unit paired with Gas Chromatography TDU-GC-MS)Differential Thermal Analysis (DTA)
And to go even further?
Going past thermal analysis, FILAB is able to fulfil a wide range of requests regarding polymers, such as :- Reverse engineering- Quality control- Failure characterization- Stability testing- And more…
Our services
Laboratory analysis of toxic trace residue
Your needs: to characterize any unknown trace residue found in your products and to ensure they comply with standards
Following the discovery of a non-compliant product or as part of a procedural improvement, industrialists can be required to carried out elemental analysis looking for trace residue in organic or inorganic matrices. Even in trace amounts, certain elements such as heavy metals (Lead, Mercury, Cadmium…) can pose a considerable health risk to consumers. Being subject to very stringent regulatory constraints, it is crucial to monitor their presence in all kinds of products.Inspections looking for trace residue require precise tools, needing to be able to detect concentrations down to the ppm or even ppb range. Support from a specialized laboratory is will therefore allow you to quickly and precisely analyze your samples.
Our solution: to provide you with quick and reliable trace analysis services for any kind of matrix
As an independent laboratory situated in Dijon, France, FILAB have been active for 30 years supporting industrialists from all fields by providing trace element analysis and characterization services. Equipped with a diverse and cutting-edge analytical fleet (ICP, GC-MS, IC, SEM EDX…) FILAB can adapt its methods to fit any kind of matrix needing to be studied (Liquids, Solids, Powders…).These are some of the services we are able to provide:
Our services
SEM-EDX trace element characterization on surfaces
Elemental analysis
Analysis of metallic impurities in pharmaceutical products (ICH Q3D)
Reverse engineering of finished products
Analysis and determination of heavy metal content using ICP-MS and ICP-AES in chemical matrices (Lead, Mercure, Cadmium, Chromium…)
Detection of elemental impurities (contaminations, pollutions, residue…)
Development of custom analytical methods
Ensuring a quick turnaround for your requests, FILAB is able to assist industrialists with regular or one-off inspections looking for trace residue. FILAB is also ISO accredited for many of these analysis for the pharmaceutical and cosmetics industries and for environmental analysis.
Our services
Deformulation, study of the chemical composition of formulas or materials
What is reverse engineering?
Reverse engineering of a commercial product, often made up of a complex mixture, involves determining the nature and quantities of the raw materials present in the formulation, by means of various chemical analyses.This application can be applied to different types of products, formulas and materials: paints, plastics (polymers), composites, metals and metal alloys, varnishes...
In what context do industries need to check the chemical composition of products or materials?
Analyze and determine the composition of an unknown mixture
Check compliance with a Safety Data Sheet (SDS) or technical data sheet
Compare the composition of several products (double-sourcing or multi-sourcing)
Analysis of competing products
Analyse and identify pollution or impurities
The success of deformulation depends on a thorough understanding of the target application and the use of rigorous analytical methods to characterize the chemical composition of the organic and inorganic fractions.
Deformulation
Our services
We can perform deformulation in a wide range of cases:
• Materials
Materials
• Glue
Glue
• Mixture
Mixture
• Polymers
Polymers
• Varnish
Varnish
• Composite
Composite
• Competing product
Competing product
• Active substance
Active substance
• Pharmaceutical product
Pharmaceutical product
• Elastomer
Elastomer
• Silicon
Silicon
• Rubber
Rubber
Our technical resources
Gas phase chromatography
(GCMS, HS-GC/MS, GC-FID, Py-GC/MS)
Infrared microscopy (IRTF)
Nuclear Magnetic Resonance (NMR)
Liquid chromatography
LCMS, LC-UV, LC-QTOF, LC-CAD...
Scanning Electron Microscopy (SEM)
Les Filab
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Contactez-nous
Pour répondre à toutes ces prestations, n'hésitez pas à contacter notre équipe.
Nous contacter
+33 (0)3 80 52 32 05
Demander un devis
Our technical resources
Laboratory determination of water contents by Karl Fischer titration
You are looking to measure the water content of a sample using the Karl Fischer method…
Karl Fischer titration is a method for determining water content in a sample. It is particularly well adapted to measure the water content of a liquid or to detect trace amounts of water, down in the ppm range, in other types of samples. The whole procedure is based on the oxidation of sulfur dioxide by diiodine.Measuring water content by Karl Fischer titration can be done with different types of samples : pharmaceutical, chemical, petroleum-based, plastic…
Our solution : to provide you with our analytical equipment designed to measure water content by Karl Fischer titration
As part of an R&D project, FILAB is able to assist industrialists from various fields in measuring the water content of their product by Karl Fischer titration.Complementary to this type of analysis, FILAB is able to study the overall characteristics of your products by providing the following services :
Our services
Chemical analysis using GC-MS, LC-MS/MS, NMR, ICP-MS…
Raw material inspections
Reverse engineering services
Determination of heavy metal content
E&L testing
Development and transfer of analytical methods
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Sectors of activity
Laboratory analysis and testing for the defense and security sector
Your needs : to design efficient, innovative and reliable materials with regard to security
As major players in the arms industry, as manufacturers of security devices, as producers of electronic components for high tech equipment, as experts in the production of nanomaterials, you are searching for a way to improve in the field of safe, reliable micro technology.Inspection of raw materialsSurface functionalizationIntegrating multiple functions into the same chipUnderstanding defects and anomaliesMiniaturizing your productsTo assist you with these various technological challenges, cooperation with a reliable, reactive laboratory with high added technical value guarantees that your products will conform to regulations and will assist you in your innovative efforts.
Our solution : to assist industrialists from the defense sector in analyzing and characterizing materials and in the development of new procedures.
As an independent laboratory situated in Dijon and housing a 2100m² analytical fleet, FILAB has a lot of experience in providing assistance as part of projects for the defense and security systems industry. FILAB offers its analytical services, its expertise and R&D advice for the following activities :
ANALYSIS
Chemical analysis : VOC, residual solvents, heavy metals, additives...
Surface analysis : welding, surface treatment, coating thickness measurements…
Microsection characterization
REACH analysis
Material characterization : metallic alloys, polymers, composite materials, glass, ceramics…
Thermal analysis
Granulometric analysis
EXPERTISE
Expertise in analytical chemistry
Deformulation services
Failure analysis : studying fissures, adhesive problems, corrosion, metallographic examination, weld analysis…
Using SEM-EDX and FTIR to identify pollutants and deposits
Compatibility studies
Laboratory audit and team training
R&D support
Creation, validation and transfer of analytical techniques
Searching for product substitutions
Literature reviews
Developing a new formula or a new product
our resources
Organic analysis : GCMS, Py-GCMS, LC-MSMS, GPC, NMR, FTIR
Thermal analysis : TGA, DSC
Powder analysis : XRD, SEM-FEG EDX, BET
Mineral analysis : ICP, XRD, IC
Metallurgic analysis : ICP, SEM-FEG EDX, OES
Surface analysis : SEM-FEG EDX, PES, ToF-SIMS
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
REACH testing in a laboratory
Your needs: to reliably analyze your chemical substances in a laboratory to be able to submit your REACH applications
REMINDER : REACH is the set of European regulations which dictate that manufacturers and chemical producers (mixtures included) producing over one ton of a substance per year must register these substances with the ECHA (European Chemical Agency based in Helsinki)
Products cannot be launched without having provided data
The REACH regulations have three registration deadlines for substances that have been pre-registered. The latest deadline of 1 June 2018 applies to substances manufactured or imported even in very small quantities (between 1 and 100 tons/year). If these substances have not been registered by June 1, 2018, they can no longer be put on the market.
60,000 applications have been registered in Europe. To date only 10,000 have been submitted.
For 2018, "between 20,000 and 25,000 substances should be registered in Europe," stated Mr. Mortureux, Director-General of Risk Prevention at the Ministry of Ecological Transition. This registration consists, for companies, of putting together records with information on the physicochemical, toxicological and ecotoxicological properties of substances, an assessment of the risks to health and the environment (based on the uses of these substances throughout their life cycle) and relevant management practices."We are expecting 60,000 applications to be registered in Europe. To date, 10,000 have been submitted," he added. This means that 50,000 French companies will have to register their chemical substances with ECHA before the deadline. This third phase of REACH registration should impact many SMEs in various sectors "the essential oils sector that may be affected," said Marc Mortureux. The new step "will affect companies that until now did not necessarily consider themselves involved". All substances are being targeted, including natural substances, organic substances and metals. Those used in industrial processes and those found in mixtures, such as in cleaning products, paints as well as substances contained in products such as textiles, furniture, computer equipment or electronic components.In January 2015, the ECHA published its “Reach 2018” roadmap which divides the registration process into seven phases and describes the key steps of each phase.
The laboratory can help you with the REACH analysis of your substances
For over 30 years, our laboratory has had the experience and specific analytical fleet to be able to assist companies with analyzing their substances as well as their mixtures and polymer or composite materials, all while providing tailored support.
OUR ANALYSIS SERVICES IN ACCORDANCE WITH REACH
Analysis of the chemical composition of a substance as part of a REACH dossier
Sameness analysis between two substances
Characterisation of nanomaterials under REACH
Deforming substances
Determination of chloroalkanes (SCCP) in accordance with REACH
OUR ANALYSIS TECHNIQUES IN LINE WITH REACH REGULATIONS
For organic substances: NMR, UV/Visible, HR-MS, GC, HPLC
For inorganic substances: IC, ICP-OES, SAA, XRD, XRF
Did you know ?
FILAB assists clients as part of the development of new chemical formulas (ex. CMR substances). For many years, FILAB has been called upon to find formulas, products or materials containing CMR substances based on REACH definitions.We provide our industrial clients with our R&D skills as well as our extensive experience to allow them to use better quality and more environmentally friendly formulas in their processes.If you wish to call on our experts to request REACH analysis or identification services, feel free to contact us !*Source : https://www.actu-environnement.com/ae/news/reach-enregistrement-substances-chimiques-juin-2018-29349.php4
Our services
REACH substance identification in a laboratory
Your needs : to characterize the chemical composition of your substances as part of the REACH registration process
REMINDER : REACH is a European regulation which requires that producers or importers of chemical substances, including mixtures register their substances with the ECHA (European CHemical Agency) if they produce/import more than one metric ton of said substances per year.
As part of this regulation, industrialists need to inspect and precisely characterize their substances to ensure that they comply with standards in order to be registered.
Any given substance must have a chemical name, a number and in the case of mixtures, their composition must be given (components + amounts). The quality of the data provided will influence the time it takes to add the substance to either the authorization or restriction list.
Before filling a REACH registration request, you are looking to cooperate with an analytical laboratory to identify and name your substances…
Our solution : to provide you with our reliable, diverse and precise analytical techniques making it possible to quickly identify the chemical nature of a substance or of a mixture
Relying on a cutting edge-analytical fleet spread over 2100m² and a team of experts in chemistry and materials science, FILAB laboratory is able to assist you in obtaining REACH registration by providing analysis and identification services for all kinds of substances :
Custom chemical analysis for identifying substances (heavy metals, residual solvents, additives…)
Purity testing
Determination of elemental contents
Raw material inspection
Chemical reverse engineering
Development of analytical methods
Material characterization
Development of Substance Identification Profiles (SIP)
To carry out these tests on all kinds of matrices, FILAB uses a diverse set of analytical techniques :
NMR : 1H, 13C, 17O, 31P…
GC-FID, GC-MS, HS-GC-MS (Gas Chromatography)
HPLC-MS/MS, HPLC-DAD (Liquid Chromatography)
IC (Ion Chromatography)
ICP-AES, ICP-MS
FTIR (Infrared Spectroscopy)
UV-Vis
DSC
XRD
TGA
SEM-EDX (Scanning Electron Microscopy)
If you wish to know more about our substance identification services, feel free to contact us !
What is the REACH regulation?
REACH is a European regulation which came into effect in 2007 to secure the manufacture and use of chemical substances in the pharmaceutical industry. In order to comply with the regulations set by the REACH registration process, substance identification is a crucial step.
Indeed, the registration process relies heavily on REACH analysis, and therefore on substance identification offered by a REACH laboratory.
What is the purpose of substance identification in a REACH laboratory ?
A substance identification lab handles a procedure involving detailed chemical analysis, which enables the identification of the exact composition of a substance. It is required to accurately characterize each component and provide reliable data on their hazards.
The chemical industry is well-versed in the importance of calling a substance identification lab as it ensures the safe handling and use of chemicals by all users and helps establish an appropriate risk management strategy.
What services does a REACH analysis laboratory offer?
A REACH laboratory provides a range of services to support companies in their REACH registration process. FILAB is capable of planning this test, in accordance with REACH chemical testing requirements.These services include testing, advice, and support to help companies comply with the complex and ever-changing REACH regulations.
A REACH analysis laboratory conducts tests to determine the chemical composition and potential hazards of products, and advises on the appropriate use of chemicals in line with REACH regulations. They also offer support in preparing and submitting REACH dossiers, and ensuring compliance with the latest updates and changes in the REACH registration process.
What is the regulation for REACH nanomaterials?
The use of nanomaterials is rapidly growing, offering numerous innovative applications, especially in the industrial sector. There are a large number of products with nanomaterials available on the European market, such as coatings, batteries, cosmetics, food products, antibacterial clothing, or textiles.
The regulation of REACH nanomaterials is an essential component of the REACH registration
process. It is a comprehensive framework that covers all aspects of nanomaterials as the properties, uses, and their potential impact on human health and the environment. The regulation requires companies to identify the nanomaterials in their products and register them with the European Chemicals Agency (ECHA).
Our services
Inspection, laboratory analysis and registration of "PMUC" products
Your needs : to have an EDF approved laboratory confirm that your products comply with PMUC regulations
“PMUC” (Products and materials for use in a power plant or “Produits et Matériaux Utilisés en Centrale électrique” in French) labeled products can potentially have corrosive effects on steel if they contain halogenated or sulfurous compounds.To be authorized to go on the market PMUC labeled products must be registered by EDF after analysis have been carried out in an approved laboratory.
The products in question are those used in power stations during production, construction, maintenance or just normal operation. There are 24 categories of “PMUC” labeled products listed by EDF : glues, varnishes/paints, anti-seize compounds, cleaning products, decontamination products, protection products, plastics, joints, products for finding or sealing leaks, abrasives...
Are you looking for a laboratory of registration PMUC products ?
PMUC analysis consists in determining the halogen (Fluorine / Fluorides, Chlorine / Chlorides, Bromine / Bromides) and sulfur contents of products designed to be used in a power station, following EDF protocols specific to each category of products.Once the analysis has been carried out a report is drafted and sent to the client to present the results to EDF for them to grant the product with the PMUC label.
Our PMUC analysis services approved by EDF
FILAB has been approved by EDF to carry out various typological PMUC analysis :Assessment of your product prior to requesting PMUC registrationRegistration testing : Chemical analysis to obtain PMUC registration productsInspections and follow-up analysis of PMUC productsPMUC chemical analysis carried out by FILAB comply with EDF’s D5713/ DJX / RB 90 0295 procedure.Inspections carried out by the laboratory consist in analyzing the halogen (Fluorides F-, Chlorides Cl-, Bromides Br-) and sulfur contents of PMUC labeled products with the aim of confirming their compliance with EDF’s specifications.Did you know ? FILAB is also a member of the Nuclear Valley organization
What does PMUC mean?
PMUC means ‘products and materials used in nuclear power plants’. They correspond to consumables used for the construction, maintenance and operation of nuclear power plants, such as stainless steel, aluminum alloys, and refractory materials.Nuclear power plants operate by harnessing nuclear energy to generate electricity, which requires products and materials capable of withstanding extreme temperatures and pressures, this is why they are subject to strict standards to ensure safety, about products and materials used.
Why do nuclear power plants need PMUC analysis ?
Determining the compliance of products and materials used in nuclear power plants (PMUC) requires laboratory analysis for each collected sample.The analysis verifies if the products meet the specified regulatory requirements. Products and materials used in nuclear power plants must meet stringent quality standards to guarantee the safety of everyone involved in the operation of the plant.The PMUC referenced products are specifically designed to meet the requirements and specifications of nuclear power plants in France.
What are the referenced products and materials used in nuclear power plants ?
Here is a non-exhaustive list of PMUC products affected by the regulations. There are 24 categories of PMUC classified products, including cleaning, decontamination, temporary protection, leak detection or sealing products, anti-seize, plastics, abrasives, paints, adhesives, oils, seals... Each category is characterized by its content of sulfur and halogen species and more specifically fluorine, bromine, chlorine. Construction materials for the plant often include stainless steel, concrete, graphite, and ceramics. Components such as reactors, steam generators, and heat exchangers are also made from heat and corrosion-resistant materials like zirconium, titanium, and stainless steel.Products used, such as lubricants and chemicals Therefore, it is important to stay updated on regulatory updates regarding PMUC (products and materials used in nuclear power plants) to ensure the safety of people and the environment.
Our services
R&D support
Are you looking for R&D support and assistance in developing or improving a product or process?
As an industrial project manager, laboratory manager, researcher or R&D engineer, you are looking for an analytical service provider to support your R&D projects.With a team of engineers and PhDs with a wide range of skills, the FILAB laboratory offers its multi-industry knowledge and R&D expertise in chemical analysis and materials characterisation.
We want to support you in your research and innovation needs through a range of services:
development of customised methods
Feasibility study
Customised training for your teams in the new method
Setting up a tailor-made method
Validation method
Transfer the method to your site
PRODUCT DEVELOPMENT OR OPTIMISATION
Literature review
Reverse engineering of materials
Laboratory tests
Industrial Transposition Assistance
Advice on the choice of materials (dual sourcing assessment)
Substitution of a CMR product
Patent registration
Internal production
PROCESS OPTIMIZATION
Determining the root cause of high scrap rates
Process audit
Optimising production processes and implementing long-term solutions
Development of surface treatment or cleaning processes
Demander un devis
FILAB : experts in R&D support
To provide you with the best possible support, the FILAB laboratory is accredited for Research Tax Credit (CIR) purposes.Through our three levels of services - analysis, expertise and R&D support - FILAB assists companies of all sectors and sizes in solving their industrial problems, providing its customers with the know-how and experience of its team.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
About us
Laboratory providing analytical and R&D services
Are you looking for a reliable laboratory to provide analytical services ?
Confronted with the multiplication of industrial challenges and with the increasingly complex issues companies are facing, service providing analytical laboratories are called being upon to assist in providing the experience needed to fulfil various types of requests :Chemical composition analysisCompliance inspectionsNon-compliance of industrial batchesProblems due to impurities, contaminations or pollutantsIncomprehension of a product failureEvaluation of the performance of industrial proceduresThese services can be called upon for various reasons from routine quality control to the implementation of more complex projects such as the analytical development or improvement of procedures.
FILAB, a laboratory providing analytical and R&D services, fulfilling your requests and with tailored support
FILAB provides services for industry relying on its dual expertise in chemistry and materials science, its cutting-edge analytical fleet and the experience of its doctors and engineers to fulfil requests relating to :
Quality Control :
Custom chemical analysisMaterial characterizationSurface analysisFailure analysis : identification of particulates and deposits, fractography, corrosion, adhesive problems…
Analytical Research and Development :
Analytical developmentClient / Supplier litigation supportR&D assistance : literature reviews, reverse engineering services, industrial transposition…Audits and analytical trainingAs an independent, service providing laboratory with a team made up of highly qualified personnel, FILAB guarantees the reliability of its results, a quick turnaround for requests and tailored support for clients. For more information about our laboratory services, feel free to contact us !
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Sectors of activity
Determination of acetaldehyde content found in cosmetic products
Your needs : to determine acetaldehyde found in your cosmetic products in accordance with relevant regulations
Acetaldehyde or ethanal is a chemical substance belonging to the aldehyde family. Acetaldehyde is a colorless liquid, naturally occurring in plants but can also be synthesized.
Found in cosmetic products, particularly perfume, acetaldehyde is used as an additive, deodorant or even as a fragrance.
Acetaldehyde is classified as a toxic substance and a suspected carcinogen. For this reason, its use in cosmetics is highly regulated and limited to low concentrations.
Are you looking for a reliable and reactive laboratory to determine acetaldehyde content in your pharmaceutical products ? Call on FILAB !
FILAB provides analytical services for the determination of acetaldehyde content in your cosmetic products
For over 10 years, FILAB laboratory has been developing a diverse analytical skillset applied to the field of cosmetics. Our laboratory is equipped with a cutting-edge analytical fleet spread over 2100m² to be able to provide services for the determination of acetaldehyde in cosmetics while fulfilling your criteria relating to product compliance.
FILAB provides tailored services for the analysis of your cosmetic products :
ANALYSES
Analysis and determination of trace amounts of acetaldehyde in your cosmetics using chromatographic techniques : HS-GC-MS, HPLC-UV, GC-MS…
Determination of active ingredients : organic and inorganic UV filters, vitamins…
Analysis of packaging : polymers, composites, glass
Expertise of non-compliances : particulates, deposits, unidentified spikes, degradations…
Compatibility testing (container/contents interactions, extractables and leachables)
Analysis of undesirable substances found in raw materials and finished products : heavy metals, residual solvents, phthalates, bisphenol A…
Determination of preservatives (phenoxyethanol, parabens, chlorphenesin…) by HPLC-UV, HPLC-MS/MS and GC-MS
Analytical validation in accordance with the ISO 12787 standard
Reverse engineering of cosmetic products
Laboratory audits and analytical training
For more information about our services for the determination of acetaldehyde content found in your cosmetic products, feel free to contact us via email at contact@filab.fr or over the phone by calling +33 (0)3 80 52 32 05
Sectors of activity
Forced degradation (stress testing) in a laboratory
Your needs : to carry out a forced degradation study on a pharmaceutical product or active pharmaceutical ingredients (API) as part of pharmaceutical development
Forced degradation studies or stress testing is a stability test used to simulate the changes in the behavior of a pharmaceutical products or active pharmaceutical ingredients. The aim is to highlight the stability of medication over time and to observe the effects of purity and the product’s compliance with standards.
These degradation studies can be performed on both active ingredients and finished products.
Are you looking to cooperate with a reliable and reactive laboratory for your forced degradation studies ? Call on FILAB !
Our solutions : to assist you in testing stability and in conducting forced degradation studies on your pharmaceutical products
FILAB laboratory is able to conduct stability testing services and to carry out forced degradation studies on your pharmaceutical products as part of an R&D project or as part of quality control. Thanks to our cutting-edge analytical fleet spread over 2100m² FILAB can provide the following services :
Stability testing and forced degradation studies in accordance with the ICH Q1A guideline
Custom chemical analysis to study a product’s stability
Method development and validation
Chemical composition analysis of a product depending on specific environmental conditions (temperature, humidity, exposure to light…) by GC-MS, HPLC or FTIR
Study of Container/Contents interactions
Analysis and identification of impurities
Analysis of active ingredients
Analysis and determination of degradation product
Reverse engineering of degradation products
Reverse engineering of pharmaceutical products
For more information about our services surrounding forced degradation studies, feel free to contact us via email at contact@filab.fr, over the phone by calling +33 (0)3 80 52 32 05 or you can request a free quote online here.
The positive aspects of FILAB
A highly qualified team
Responsiveness in responding to and processing requests
A COFRAC ISO 17025 accredited laboratory
(Litters available on www.cofrac.com - Accreditation number: 1-1793)
A complete analytical park of 2100m²
Tailor-made support
A SAFRAN approval
Our services
Laboratory study of plasticizer migration phenomena
Are you looking to study the migration of plasticizers found in your packaging materials ?
Plasticizers, including phthalates, are oily, odorless liquids that are regularly used to improve the physical properties of plastic materials. These plasticizers can be dangerous for human health and the environment if they are released or if they leach into a product. The EU and the FDA have regulated the use of plasticizers to limit such risks. As an industrialist, you are required to meet these requirements to avoid any product degradation and any health risks for your customers. A study of plasticizer migration into your product is therefore essential to better understand these phenomena.
FILAB laboratory is able to provide you with its analytical equipment to study the risks of plasticizer migration in your packaging materials
For over 30 years, FILAB has been developing a wide analytical skill set in relation with plasticizer migration phenomena. Our laboratory is equipped with a cutting-edge analytical fleet spread over 2100m² and offers a high level of technical skill to be able to provide services fulfilling our clients’ compliance criteria as part of plasticizer migration testing.FILAB is able to provide tailored services for the analysis of your packaging materials and of hazardous substances :Migration testing on packaging after an accelerated aging procedureDetermination of unwanted substances, namely plasticizers found in formulations by GC-MS, LC-MS, HS-GC-MS, FTIR…Determination of phthalates and other substances of concern : heavy metals, bisphenol A, solar filters…Physicochemical characterization of packaging materialsReverse engineering of cosmetic products
Our services
Identification and determination of additives in your polymers
An additive is a chemical substance incorporated into polymers to improve their final properties. Additives can be used to have a positive effect on production, storage, treatment, during and after a product’s use.These additives can be plasticizers, dyes, solvents, lubricants, etc.As part of the development or optimization of a product, after a change in regulations or following a product failure, you are looking to characterize and determine the presence of additives in your polymers with support from a specialized laboratory.
FILAB is able to provide you with our analytical equipment and the expertise of our engineers for the determination and analysis of additives in polymers
With the use of complementary analytical tools and our dual expertise in chemistry and materials science, FILAB is able to carry out physicochemical analysis making it possible to characterization the presence of additives in your polymers :Identification of additives found in a polymerDetermination of additive content in a polymerVerification of the composition of a polymer compared with its SDS, namely its additive contentAccelerated aging testsReverse engineering of polymers to measure the presence of additivesDevelopment and analytical validation specific to additives To carry out these different services, FILAB laboratory uses a wide range of analytical techniques, such as :Thermal analysis by DSC or TGAChromatographic analysis (GC-MS or HPLC) to identify volatile additivesSpectrometric analysis (FTIR, ICP-MS and ICP-AES) to measure the presence of an additive in a polymerWith three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Sectors of activity
Laboratory analysis of pharmaceutical formulations
Why monitor the quality of your pharmaceutical formulations ?
The pharmaceutical industry is one of the more stringent industries in terms of regulations. For this reason, many industrial pharmaceutical producers, of products intended for either animal or human consumption, are faced with numerous quality requirements.Regulations surrounding the quality of pharmaceutical formulations are not just applied during a product’s lifecycle, but also during development and marketing phases. All these quality control tests on pharmaceutical formulations are referenced in Pharmacopeias (USP, EP).The non-compliance of a pharmaceutical formulation (impurities, API/excipient interactions…) could cause the product to not be authorized to be put to market or to be called back.Are you looking for a reliable and reactive for the analysis of pharmaceutical formulations ? Call on FILAB !
FILAB is able to assist you in analyzing the compliance of your pharmaceutical formulations
FILAB offers pharmaceutical industrialists with a high level of skill and a cutting-edge analytical fleet to provide services fulfilling their criteria in terms of compliance to standards relevant to all kinds of galenic pharmaceutical formulations.FILAB laboratory is the only French laboratory to be ISO 17025 accredited (www.cofrac.fr accreditation n°1-1793) for the analysis of elemental impurities in pharmaceutical matrices and for the analysis of pharmaceutical formulations in accordance with GMPs.To reliably and precisely resolve these problems, FILAB offers tailored support for the analysis of your pharmaceutical formulations :Chemical analysis of your pharmaceutical formulations by GC-MS, LC-MS, ICP…Analysis of pharmaceutical formulations following ICH and VICH guidelinesDetection of elemental impurities in your pharmaceutical formulations by ICP-MS or ICP-AESAnalysis of particulates in your pharmaceutical formulations (troubleshooting) by MEB-EDX, FTIR, LC-MS/MSReverse engineering of your pharmaceutical formulationsExtractables and leachables (E&L) testing For more information about our analytical services relating to pharmaceutical formulations, feel free to contact us via email at contact@filab.fr, over the phone by calling +33 (0)3 80 52 32 05 or request a free quote online here.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Sectors of activity
Laboratory analysis of pharmaceutical powder
Are you looking to analyze your pharmaceutical powder or raw materials in accordance with relevant regulations?
According to the European Pharmacopeia, a pharmaceutical powder is defined as “as a dry, solid substance, composed of finely divided drugs with or without excipients and intended for internal or external use. It is a solid substance in finely divided state typically obtained by crushing, grinding, or comminuting”.
Powdered medications can be found in various forms : pills, effervescent powders, inhalable products, powders intended for injectable solutions… Powdered medications are mainly administered orally, nasally or by inhalation.
The quality requirements of powdered medications can need to be analyzed both during the process of putting a medication to market and at any point during a product’s lifecycle. Assurance of the high quality of powders leads pharmaceutical industrialists to carry out numerous quality control tests in accordance with well-defined references such as pharmacopeias.
Our solution : to assist pharmaceutical producers in analyzing their products (raw materials and finished products)
FILAB offers pharmaceutical industrialists a high level of technical skill and a cutting-edge analytical fleet to provide them with services fulfilling their criteria relating to product compliance and adherence to regulatory standards for all kinds of powdered medications.
To reliably and precisely resolve these problems, FILAB provides tailored support for the analysis of pharmaceutical powders :
Purity testing on active ingredients
Chemical composition analysis of your pharmaceutical powders by GC-MS, LC-MS, ICP…
Polymorphism testing
Physicochemical testing : PSD, flowability, morphology, porosity…
Detection of elemental impurities in your pharmaceutical powders (ICH Q3D) by ICP-MS or ICP-AES
Reverse engineering of your pharmaceutical powders
Problem solving : odor, discoloration, degradation…
The positive aspects of FILAB
A highly qualified team
Responsiveness in responding to and processing requests
A COFRAC ISO 17025 accredited laboratory
(Litters available on www.cofrac.com - Accreditation number: 1-1793)
A complete analytical park of 2100m²
Tailor-made support
A SAFRAN approval
Sectors of activity
Laboratory analysis of pharmaceutical products intended for animal consumption
Your needs : to inspect the quality of your pharmaceutical products intended for animal consumption
Just as is the case for products intended for human consumption, animal health industrialists are also confronted with drug quality standards. These quality requirements, which apply to both the marketing of a drug and its life cycle, require the manufacturers of animal health products to carry out several quality-control tests.The non-compliance of pharmaceutical products intended for animal health (presence of pollutants, container/contents interactions) could lead to a product being called back or for a product to not be authorized to go to market.To overcome these technical challenges, you are looking to cooperate with a reliable and reactive analytical laboratory.
Our solution : to assist animal healthcare industrialists in analyzing the quality of pharmaceutical products
FILAB offers animal healthcare industrialists a high level of technical skill along with a cutting-edge analytical fleet to be able to provide services fulfilling their criteria in terms of compliance with relevant standards applicable to all kinds of galenic medications
Did you know that
?
FILAB laboratory is the only French laboratory to have ISO 17025 accreditation (www.cofrac.fr – accreditation n°1-1793) for the analysis of elemental impurities in pharmaceutical matrices and carries out analysis of medications in line with GMPs.To solve these problems, FILAB provides tailored support for analysis of pharmaceutical products intended for animal consumption :
our services
Chemical analysis of your medications by GC-MS, LC-MS, ICP…
Detection of elemental impurities in your medications (VICH) by ICP-MS and ICP-AES
Reverse engineering of your animal medications
Analysis following VICH guidelines
Particulate analysis of your medications (troubleshooting) by SEM-EDX, FTIR, LC-MS/MS…
Extractible and leachable testing
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Laboratory analysis of Polyvinyl chloride (PVC) materials
Your needs: to verify the quality and the performance of your polyvinyl chloride materials
Polyvinyl chloride or PVC is a widely used thermoplastic polymer which can often be found as a white, odorless powder. This powder can be used with different additives and take on many different shapes.After setting, PVC can be either solid or flexible, transparent or opaque, colorless or dyed.PVC is widely used, most notably in construction, packaging, clothing and in automobiles…Chemical analysis and characterization of polyvinyl chlorides is an essential step to controlling their transformation into usable products and in preventing the apparition of potential defects. Analysis is manly used to :Determine the chemical composition of polyvinyl chloridePhysiochemically and thermally characterize PVC materials : density, molecular mass, thermal analysis, calorimetric analysis…Identify the chemical nature of a PVC sample and its additivesDetermine the mineral filler being used (chalk, talc…)To characterize a defect (adhesive problem, disbonding, inclusions…)Verify that a finished product complies with standardsWorking with plastics, as producers of raw materials or as manufacturers using plastics, you are looking to cooperate with a reliable laboratory offering analysis with high added technical value to analyze and characterize your PVC materials.
Our solution: to assist you in analyzing and characterizing your polyvinyl chloride samples
By combining analytical tools specific to polyvinyl chlorides with our precise and reliable scientific knowledge, FILAB laboratory is able to assist industrialists in optimizing their production processes, in researching possible material substitutions and in resolving problems caused by defects found in PVC materials.With extensive experience in analyzing polyethylene and being equipped with a diverse analytical fleet, FILAB laboratory is able to provide the following services :Characterization of PVC materials : physicochemical and thermal properties by DSC, TGA, TGA-FTIR, GPC, NMR, SEM and FTIRCustom chemical analysis : detection of additives by GC-MS, Py-GC-MS, LC-MS/MS, IC…Detection of impurities : heavy metals, residual solvents, degradation products, contaminations…Reverse engineering of polyvinyl chloride materialsDetermination of molecular mass by GPCCompatibility testing between PVC materials and various fluids
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Laboratory measurement of osmolality
FILAB's laboratory measurement of osmolality is an essential chemical analysis service, particularly vital for sectors like pharmaceuticals and cosmetics. This analysis helps ensure product safety and efficacy by measuring the concentration of solutes in a solution, which can affect product stability and performance. FILAB employs advanced methodologies to provide precise osmolality measurements, aligning with strict industry standards to support client needs in quality control and regulatory compliance.
Osmolality
Osmolality is a concentration that can be measured after osmosis has occurred. Osmosis is a physical law corresponding to the passage of a solution from a hypotonic medium to a hypertonic medium through a semipermeable membrane. Osmolality this therefore defined as the number of osmoles of solutes per kilogram of solvent, measured in osmol/kg.Osmolality is used because the volume of solvent stays constant in any conditions (temperature, pressure, etc.) . FILAB laboratory realise mesurement of osmolality.
Measurement of osmolality for the cosmetics industry
In the cosmetics industry, osmolality measurements can be needed to measure the effectiveness of active ingredients. While making a cosmetic crème, the osmolality of raw materials can give an indication of the quantity of particles capable of seeping through semipermeable cell walls. It is therefore possible to determine if a crème containing the active ingredient will be effective or not. It is also possible to determine if the active ingredient disturbs the balance in a cell, which would disqualify the sample.As an industrialist in the cosmetics industry, you are looking to measure the osmolality of your solutions.
Measurement of osmolality for the pharmaceutical industry
Osmolality therefore applies to any element (ion, molecule) capable of attracting water molecules though a membrane. That is why this property is often sort after for a better tolerance (ex. injectable solutions).The European Pharmacopeia 2.2.35 “Osmolality Standards USP 785” describes the principle behind analytical methods, provides a clear and detailed description of a sampling procedure et provides precision requirements for sampling.FILAB laboratory is able to assist you in measuring osmolality in accordance with the European Pharmacopeia
FILAB is able to measure osmolality in its laboratory and can assist you with your analytical needs
FILAB is an independent laboratory situated in Dijon, France and can assist you in measuring osmolality to resolve your quality, safety and performance problems.Our experts provide multiple analytical services centered around osmolality measurements :
our services
Osmolality measurements in accordance with the European Pharmacopeia
Osmolarity measurements
Detection of elemental impurities in excipients in accordance with the USP 233 (ICH Q3D)
Analytical development and validation of methods for quantifying substances in accordance with various standards : ICH, USP, EP, ISO…
Expertise to understand osmolality differences between samples
Particulate count and analysis
Compatibility testing between active ingredients and excipients
Reverse engineering of finished products
What is the difference between osmolality and osmolarity measurement ?
Osmolality and osmolarity are both measurements that refer to the concentration of solutes in a solution, but they are measured in different ways. Osmolality is a measure of the total number of particles in a solution per unit of solvent, typically expressed as osmoles per kilogram of solvent (osmol/kg). Osmolality is determined by measuring the freezing point depression of the solution using an osmometer. This method takes into account all solutes present in the solution, regardless of whether they dissociate in water or not. Osmolarity, on the other hand, is a measure of the total number of particles in a solution per unit of volume of solution, typically expressed as osmoles per liter of solution (osmol/L). Osmolarity is calculated based on the concentrations of individual solutes and their contributions to the overall osmotic pressure of the solution. This method assumes that all solutes in the solution are fully dissociated in water. The main difference between osmolality and osmolarity measurement is the way they take into account the presence of non-dissociating solutes (such as urea), which contribute to osmolality but not osmolarity. Osmolality is considered to be a more accurate measure of the effective osmotic pressure of a solution, while osmolarity is useful for calculating the expected movement of water across cell membranes. In summary, osmolality measures the total number of particles in a solution per unit of solvent, while osmolarity measures the total number of particles per unit of volume of solution.
How to measure osmolarity ?
Osmolarity can be measured using several methods, including: Freezing point depression: This method involves measuring the freezing point depression of a solution compared to a pure solvent. Osmometers are specialized instruments that use this method to calculate the osmolarity of a solution based on its freezing point depression. Vapor pressure: Vapor pressure osmometry measures the decrease in vapor pressure caused by the presence of solutes in a solution. This method is commonly used for measuring the osmolarity of biological fluids such as blood and urine. Calculation: Osmolarity can also be calculated based on the concentrations of individual solutes in a solution, using the formula: Osmolarity = (sum of [solute] x number of particles per molecule) / volume of solution For example, a 0.9% saline solution contains 9 grams of NaCl per 1000 ml of solution. The osmolarity of NaCl is 2, so the osmolarity of the solution can be calculated as: Osmolarity = (9 g/L x 2) / 0.1000 L = 180 Osm/L Conductivity: Another method for measuring osmolarity is by measuring the electrical conductivity of a solution. The conductivity of a solution is proportional to the concentration of ions present, which can be used to calculate the osmolarity.Overall, choosing how to measure osmolarity depends on the type of solution being tested and the equipment available in the chemical analysis laboratory.
How to know if I need osmolality or osmolarity measurement ?
Whether to measure osmolality or osmolarity depends on the type of sample being tested and the purpose of the test. When making a request to a chemical analysis laboratory, it is important to provide as much information as possible about the sample being tested and the purpose of the analysis. Based on this information, the laboratory professionals can recommend whether osmolality or osmolarity measurement is more appropriate for the specific needs of the experiment or analysis. Osmolality measurement is often preferred in clinical settings and for biological samples such as blood, urine, and other bodily fluids, as it is a more accurate measure of the solute concentration in a solution. This is because osmolality is not affected by changes in temperature or pressure, which can affect osmolarity measurements. Additionally, certain solutes present in biological samples, such as urea, contribute to osmolality but not osmolarity, making osmolality a more comprehensive measure of solute concentration. On the other hand, osmolarity may be more appropriate for solutions with well-characterized solutes, such as salt solutions used in cell culture. In these cases, specific solutes are known, and their contributions to the total osmotic pressure can be accurately calculated using osmolarity measurements. Ultimately, the choice between osmolality and osmolarity measurements depends on the specific needs of the experiment or analysis being conducted. If you are unsure which measurement to use, consulting with a laboratory professional or an expert in the field can help determine the best approach.
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Chemical analysis laboratory Brussels
Your needs from Brussels and Belgium: analyse the chemical substances that make up your finished products and raw materials
Chemical analysis has become increasingly vital in the industry today, given the rise of global competition and growing complexity of regulatory constraints. The accurate measurement and understanding of chemical properties and performance are essential to ensure product quality and safety. In most industries, chemical analysis is used to guarantee that raw materials and finished products meet specific standards and comply with regulations. It is therefore crucial to adopt a robust analytical approach to monitor critical attributes and achieve high-quality products. Failure to do so can lead to significant consequences, including regulatory penalties, damage to the reputation of the brand, and, in extreme cases, a risk to public health. Hence, chemical analysis has become an essential tool for maintaining product integrity and ensuring compliance with regulations in today's competitive business environment.The FILAB laboratory, which specialises in chemical analysis and has state-of-the-art analytical methods, is there to help you in your processes.Located in Burgundy, in Dijon, in the middle of the Paris-Lyon axis, the Filab laboratory is easily accessible by train or car.With more than 15 years of experience, particularly with an increasingly important Belgian clientele, the Filab chemical and analytical laboratory is a privileged service provider thanks to its knowledge of the problems encountered by companies based in Brussels and in Belgium.
I contact the FILAB laboratory
Our solutions: supporting manufacturers with tailor-made chemical analysis services.
Thanks to its high-level, multidisciplinary team, the FILAB analytical chemistry laboratory offers a wide range of chemical analysis services to control all your raw materials and finished products.
Our chemical analysis
Analysis of raw materials (search for impurities)
REACH analysis
Industrial chemical analysis
Basic chemical analysis
Analysis of contamination and pollution
Analysis of polymeric and composite materials, metallurgy and ceramics
Chemical analysis following failure
Heavy metal analysis
Analysis baths surface treatment
ISO 17025 accredited analysis laboratory
Laboratory analysis and biocompatibility testing according to ISO 10993
Analysis of phthalates and DEHP
Analysis of Bisphenol A
Analysis of residual solvents
Analysis of cleaning product residues on medical devices: HCT / TOC
Particle size analysis
Paint and varnish analysis
Chemical deformation (reverse engineering)
Development and validation of chemical analysis methods
Our techniques
GC-MS, HS-GCMS (Gas Chromatography)
HPLC-MS/MS, HPLC-DAD (Liquid Phase Chromatography)
ICP-AES, ICP-MS
FTIR (Infrared Spectroscopy)
DSC
UV (UV-Visible spectroscopy..)
IC (Ion Chromatography)
SEM-EDX (Scanning Electron Microscopy)
The FILAB laboratory helps companies of all sectors and sizes to solve their industrial problems. We provide you with the know-how and experience of our team of PhD students and engineers.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Cities
Chemical analysis laboratory Geneva
Your needs from Switzerland and Geneva: analyse the chemical substances that make up your finished products and raw materials
The performance and properties of industrial products have directly influenced the success of many companies. To ensure that these products meet the regulatory standards and comply with quality control, chemical analysis has become a necessity in all industrial sectors. Conducting chemical analysis helps manufacturers identify the presence of any contaminants or impurities that may compromise the product's quality. This process provides insight into the product's chemical composition and helps identify discrepancies that may result in product failure. As such, chemical analysis plays a crucial role in maintaining the overall integrity and safety of industrial products.Our laboratory, which specialises in chemical analysis and has state-of-the-art analytical methods, is there to help you in this process.Located in the heart of Burgundy, in Dijon, in the middle of the Paris-Lyon-Geneva axis, the Filab laboratory is quickly accessible for companies based in Switzerland.How long is the journey from Geneva to Dijon by car?It takes about 2h45 by car from Geneva to Dijon on the motorway.How long does it take to get from Geneva to Dijon by train?The fastest TGV takes about 2h40 from station to station. Once in Dijon, the Filab laboratory is easily accessible by tram or the city's bus network.
I contact the FILAB laboratory
Our solutions: supporting manufacturers with tailor-made chemical analysis services.
Thanks to its high-level, multidisciplinary team, the FILAB analytical chemistry laboratory offers a wide range of chemical analysis services to control all your raw materials and finished products.With over 20 years of experience, specifically catering to a growing Swiss clientele, Filab is a renowned chemical and analytical laboratory. We specialize in understanding and resolving challenges faced by businesses in and around Geneva.
Our chemical analysis
Analysis of raw materials (search for impurities)
REACH analysis
Industrial chemical analysis
Basic chemical analysis
Analysis of contamination and pollution
Analysis of polymeric and composite materials, metallurgy and ceramics
Chemical analysis following failure
Heavy metal analysis
Analysis baths surface treatment
ISO 17025 accredited analysis laboratory
Laboratory analysis and biocompatibility testing according to ISO 10993
Analysis of phthalates and DEHP
Analysis of Bisphenol A
Analysis of residual solvents
Analysis of cleaning product residues on medical devices: HCT / TOC
Particle size analysis
Paint and varnish analysis
Chemical deformation (reverse engineering)
Development and validation of chemical analysis methods
Our techniques
GC-MS, HS-GCMS (Gas Chromatography)
HPLC-MS/MS, HPLC-DAD (Liquid Phase Chromatography)
ICP-AES, ICP-MS
FTIR (Infrared Spectroscopy)
DSC
UV (UV-Visible Spectrometry..)
IC (Ion Chromatography)
SEM-EDX (Scanning Electron Microscopy)
The FILAB laboratory helps companies of all sectors and sizes to solve their industrial problems. We provide you with the know-how and experience of our team of PhD students and engineers.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Cities
Chemical analysis laboratory Lausanne
Your needs from Switzerland and Lausanne: analyse the chemical substances that make up your finished products and raw materials
In today's industrial world, companies have to ensure the safety and performance of their products. One of the best ways to achieve this is through chemical analysis. By analyzing the performance and properties of products, companies can ensure regulatory compliance and prevent product failure. Chemical analysis is a vital tool in quality control as it provides valuable insights into the components of a product and how they interact with each other. Whether it's the composition of a pharmaceutical drug or the properties of a new building material, chemical analysis is essential to maintain safety and quality standards in every industrial sector. To do this, the use of analytical chemistry makes it possible to obtain quantitative chemical analysis (concentration and dosage of components) or qualitative analysis (nature of a chemical composition).The FILAB analytical chemistry laboratory, that has high-level analytical methods, is there to help you in this process.Located in the Burgundy-Franche-Comté region, in Dijon, the Filab laboratory is quickly accessible for companies based in Switzerland and near Lausanne.How long is the journey from Lausanne to Dijon by car?It takes about 2 hours and 43 minutes to drive from Lausanne to Dijon on the motorway.How long does it take to get from Lausanne to Dijon by train?The fastest TGV takes about 2 hours from station to station. Once in Dijon, the Filab laboratory is easily accessible by tram or the city's bus network.
I contact the FILAB laboratory
Our solutions: supporting manufacturers with tailor-made chemical analysis services.
Thanks to its high-level, multidisciplinary team, the FILAB analytical chemistry laboratory offers a wide range of chemical analysis services to control all your raw materials and finished products. With over 15 years of experience, particularly catering to a growing and significant customer base in Switzerland, Filab chemical and analytical laboratory stands out as a trusted service provider. Our expertise in addressing the challenges faced by businesses in Lausanne and throughout Switzerland sets us apart.
Our chemical analysis
Analysis of raw materials (search for impurities)
REACH analysis
Industrial chemical analysis
Basic chemical analysis
Analysis of contamination and pollution
Analysis of polymeric and composite materials, metallurgy and ceramics
Chemical analysis following failure
Heavy metal analysis
Analysis baths surface treatment
ISO 17025 accredited analysis laboratory
Laboratory analysis and biocompatibility testing according to ISO 10993
Analysis of phthalates and DEHP
Analysis of Bisphenol A
Analysis of residual solvents
Analysis of cleaning product residues on medical devices: HCT / TOC
Particle size analysis
Paint and varnish analysis
Chemical deformation (reverse engineering)
Development and validation of chemical analysis methods
Our techniques
GC-MS, HS-GCMS (Gas Chromatography)
HPLC-MS/MS, HPLC-DAD (Liquid Phase Chromatography)
ICP-AES, ICP-MS
FTIR (Infrared Spectroscopy)
DSC
UV (UV-Visible Spectrometry..)
IC (Ion Chromatography)
SEM-EDX (Scanning Electron Microscopy)
The FILAB laboratory helps companies of all sectors and sizes to solve their industrial problems. We provide you with the know-how and experience of our team of PhD students and engineers.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Cities
Chemical analysis laboratory Paris
Your needs: analyse the chemical substances that make up your finished products and raw materials in the Ile-de-France region and Paris (75)
Ensuring product performance and quality is crucial for any industrial sector to thrive. This is where chemical analysis plays a pivotal role. From identifying contaminants, to checking composition and physical properties, chemical analysis can provide valuable insights into any product's characteristics. In addition, adherence to regulatory compliance is paramount in any industry. Chemical analysis helps ensure compliance with laws and regulations while detecting any failure that may have occurred. By utilizing chemical analysis, industrial sectors can remain competitive while providing high-quality products to their customers. To accomplish this, the use of analytical chemistry makes it possible to obtain quantitative chemical analysis (concentration and dosage of components) or qualitative analysis (nature of a chemical composition).Our laboratory specialized in chemical analysis and has cutting-edge analytical methods, is there to guide you in this process.Located in the heart of Burgundy, in Dijon, in the middle of the Paris-Lyon axis, the Filab laboratory is quickly accessible for companies based in the Paris region and Ile-de-France.How long is the journey from Paris to Dijon by car?It takes about 3 hours by car on the A6 motorway, direction Lyon, from Paris to reach Dijon.How long is the journey from Paris to Dijon by train?The average train journey between Paris and Dijon is 2.5 hours. The fastest TGV takes about 1.5 hours from station to station. There are currently 16 possible journeys per day. Once in Dijon, the Filab laboratory is easily accessible via the tram or the city's bus network.
I contact the FILAB laboratory
Our solutions: supporting manufacturers with tailor-made chemical analysis services.
Thanks to its high-level, multidisciplinary team, the FILAB analytical chemistry laboratory offers a wide range of chemical analysis services to control all your raw materials and finished products.With over 15 years of experience, especially serving a growing Parisian clientele, the Filab chemical and analytical lab is a trusted provider due to its expertise in addressing the challenges faced by businesses in Paris and the surrounding areas.
Our chemical analysis
Analysis of raw materials (search for impurities)
REACH analysis
Industrial chemical analysis
Basic chemical analysis
Analysis of contamination and pollution
Analysis of polymeric and composite materials, metallurgy and ceramics
Chemical analysis following failure
Heavy metal analysis
Analysis baths surface treatment
ISO 17025 accredited analysis laboratory
Laboratory analysis and biocompatibility testing according to ISO 10993
Analysis of phthalates and DEHP
Analysis of Bisphenol A
Analysis of residual solvents
Analysis of cleaning product residues on medical devices: HCT / TOC
Particle size analysis
Paint and varnish analysis
Chemical deformation (reverse engineering)
Development and validation of chemical analysis methods
Our techniques
GC-MS, HS-GCMS (Gas Chromatography)
HPLC-MS/MS, HPLC-DAD (Liquid Phase Chromatography)
ICP-AES, ICP-MS
FTIR (Infrared Spectroscopy)
DSC
UV (UV-Visible Spectrometry..)
IC (Ion Chromatography)
SEM-EDX (Scanning Electron Microscopy)
The FILAB laboratory helps companies of all sectors and sizes to solve their industrial problems. We provide you with the know-how and experience of our team of PhD students and engineers.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Laboratory analysis of Azodicarbonamide (CAS No.123-77-3)
The determination of azodicarbonamide by FILAB is an essential chemical analysis service tailored for industries using this chemical in products like plastics and resins. FILAB's comprehensive testing ensures accurate characterization of azodicarbonamide through advanced methods such as chromatography and spectrometry, supporting both quality control and regulatory compliance. This service is vital for assessing product safety and enhancing material properties.
What is Azodicarbonamide (CAS No.123-77-3)?
Azodicarbonamide is a molecule often found in the form of an odorless reddish yellow powder and is used as a food additive (E927). It is a chemical blowing agent added to flour in order to improve dough. However, it is not used in the European Union as a flour treatment agent.Azodicarbonamide is also used in foaming plastics to make them stronger, lighter, spongy and more malleable.This molecule is also known as a chemical processing agent for thermoplastics and epoxy resins, its gas yield of 220 ml/g makes it very economical.Azodicarbonamide is also a solid explosive. It can explode on impact or by friction, heat or other means with rapid decomposition to produce large quantities of gas.
Our solution : to analyze Azodicarbonamide (CAS No.123-77-3)
Techniques used to analyze azodicarbonamide
Thanks to the complementarity of our analytical tools and our dual expertise in chemistry and materials science, FILAB laboratory is able to carry out physicochemical analysis to characterize the presence of azodicarbonamide in your industrial materials :Determination of azodicarbonamideAssessment of a product’s composition compared to their SDSChemical analysis of varnish and resinPolymer analysisAccelerated aging test on a product containing azodicarbonamideReverse engineering of a product to assess the presence of azodicarbonamideAnalytical development and validationTo carry out these various services, FILAB laboratory uses a wide variety of analytical techniques such as :Thermal analysis by DSC or TGAChromatographic analysis (GC-MS or HPLC) to identify any volatile azodicarbonamideSpectrometric analysis (FTIR, ICP-MS and ICP-AES) to measure the presence of azodicarbonamide in a polymer
Why call on FILAB to analyze azodicarbonamide ?
With three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 2100m²
Un accompagnement sur-mesure
Our services
Substance characterization laboratory for a REACH registration
You want to characterize a substance for a REACH
registration...
REACH is a European regulation that requires all manufacturers and importers of chemical substances, including mixtures, with a volume of more than one ton per year, to register these substances with the ECHA (European Chemicals Agency).Within the context of this regulation, manufacturers are required to precisely characterize the identity of their substances in order to guarantee their compliance with the registration process.Indeed, a substance must be associated with a chemical name, a number and, for mixtures, a detailed chemical composition (components + dosages). The quality of the data provided will allow to quickly classify these substances in the authorization or restriction lists.Before a REACH registration, you are looking for a chemical analysis laboratory to characterize a substance.
FILAB laboratory offers you its analytical equipment and the expertise of its engineers to characterize a substance within the framework of REACH
With an analytical park of 2,100m² and a team of experts in chemistry and materials, the FILAB laboratory can assist you in characterizing a substance for REACH registration by offering the following analytical services :Custom chemical analysis and substance identification (heavy metals, residual solvents, additives...)Purity analysisDetermination of elementsControl of raw materialsChemical deformationDevelopment of analytical methodsMaterial characterizationSubstance Identification Profile (SIP)To perform these controls on all types of matrices, FILAB has various analytical means at its disposal:RMN: 1H, 13C, 17O, 31P...GC-FID, GC-MS, HS-GCMS (Gas Chromatography)HPLC-MS/MS, HPLC-DAD (Liquid Phase Chromatography)IC (Ion Chromatography)ICP-AES, ICP-MSFTIR (Infrared Spectroscopy)UV/ VisibleDSCDRXTGASEM-EDX (Scanning Electron Microscopy)If you want to know more about our services of substance characterization for a REACH registration, contact us!
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