OECD 125: Measurement of particle size and particle size distribution of nanomaterials in the laboratory

OECD 125 establishes a precise framework for measuring the size and particle size distribution of particles and fibres in the range 1 to 1000 nm. This characterisation is crucial for :

• Validate the properties of a material in a research and development context.
• Compare different production batches to ensure product consistency and quality.
• Understanding the behaviour of nanomaterials, particularly in terms of reactivity and interactions with the environment.

The use of nanomaterials is subject to strict regulations in various sectors (cosmetics, pharmaceuticals, medical devices, chemicals, etc.). Following the OECD 125 standard allows you to :

• Meet regulatory obligations relating to the classification of nanomaterials (REACH, FDA, ISO, etc.). nanomatériaux (REACH, FDA, ISO, etc.).
• Provide reliable data to the authorities for the registration and marketing authorisation of products containing nanomaterials.
• Demonstrate the safety of a product in relation to current regulations.

The methods recommended by OECD 125 are based on proven techniques (SEM, TEM, DLS, SAXS, etc.) and validated by inter-laboratory studies. This guarantees

• Standardised results, enabling reliable comparisons between laboratories and studies.
• Better traceability of analysis, essential for manufacturers and regulatory bodies.

In sectors such as aeronautics, medical devices and energy, controlling particle size makes it possible to optimise :

• Materials performance (e.g. mechanical, thermal and optical properties).
• Product formulations (e.g. suspension stability, reactivity control).
• Quality control of industrial production, by ensuring that the characteristics of nanoparticles comply with specifications.