Deformulation of an active ingredient in the laboratory
You want to make a deformulation of your active ingredient?
What is an active ingredient?
An active ingredient is a chemical substance present in the composition of a drug that gives it its therapeutic or preventive properties.
There are several ways to synthesize active ingredients on an industrial scale:
- They can be extracted from natural sources, an interesting technique especially when the active substances are relatively complex
- By chemical means, when the active ingredients are simple
- and finally, by genetic engineering by inserting a gene coding for a protein into a bacterium, for example.
Why distort the active ingredient of your pharmaceutical products?
This process of deformulation is particularly used by manufacturers in order to :
- Develop a new formulation of the active ingredient
- Analyze two formulations of the active ingredient in a comparative way (double-sourcing or multi-surcing)
- Determine the exact composition of the active ingredient
- Analyze and identify an impurity in the active ingredient
Our solutions: to accompany you in your project of deforming the active ingredient of a pharmaceutical product
Successful deformulation is the result of a good knowledge of the targeted application and the implementation of precise and tailor-made analytical methods.
With its state-of-the-art analytical facilities (a technical platform of more than 2,100 m2) and qualified and experienced staff, FILAB can assist you in your pharmaceutical deformulation projects, with tailor-made monitoring and expertise.
In order to support its customers in their active ingredient deformulation projects, FILAB has a range of diversified and sometimes very advanced techniques:
our resources
Gas chromatography coupled to mass spectrometry (GCMS)
Spectrometric analysis by ICP-MS and ICP-AES
Analysis by liquid chromatography using CLI
