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Reverse engineering of plastic (polymer) matter
Your needs: to identify the chemical composition of a polymer or composite material
You are looking to reverse engineer polymer or composite materials with the aim of :Determining the chemical composition of a reference materialVerifying that polymers comply with their Safety Data Sheet (SDS)Comparing the physicochemical properties of multiple plastic products
Our solution: to provide you with a wide range of diverse techniques for characterizing polymers
Our laboratory’s analytical services
For over 30 years, FILAB laboratory has had the experience and specific analytical fleet to be able to assist companies in physiochemically characterizing their plastic and polymer materials.FILAB is able to provide a combination of analytical techniques to reverse engineer a polymer by studying their properties and chemical composition of your polymers :Infrared microscopy (FTIR) : polymer family identificationGC-MS : detection of organic additivesICP : detection of mineral elements (fillers and additives)SEM FEG EDX : dimensional and morphological observationsGPC : molecular weight measurementPy-GC-MS : characterization of the presence of organic additivesTGA-FTIR : identification of released gasses based on temperatureXRD : study of crystalline phasesDSC : polymerization measurements
Why FILAB?
As an independent laboratory with a team made up of highly qualified personnel, FILAB guarantees the reliability of its results, a quick turnaround for requests and tailored support for clients.
Our services
Reverse Engineering in Laboratory
You want to determine the composition of a product by the reverse engineering method.
Reverse engineering, also called deformation or reverse engineering, is a method to determine the chemical composition of a complex mixture using various chemical analysis.In addition to providing a better understanding of a material, reverse engineering allows for a better understanding of structural issues but also its defective quality. Thus, the objective of reverse engineering can, among other things, be to improve the performance of a material and/or to better target a new supplier.This application concerns different types of products, formulas and materials: paints, metals, alloys, varnishes, plastics, cosmetics, aqueous formulations, composites...The method of successful reverse engineering lies in a good knowledge of the targeted application and the implementation of rigorous analytical methods to characterize the composition of organic and mineral fractions.
FILAB supports you in your reverse engineering efforts
Reverse engineering can be used to meet various needs such as:
Our services
Analyze and determine the composition of an unknown mixture
Check compliance with a Safety Data Sheet (SDS) or a technical data sheet
Compare the composition of several products (double-sourcing or multi-sourcing)
Analyze and identify a pollution or an impurity
Par ailleurs, l'ingénierie inverse implique un ensemble de techniques diversifiées, parfois très pointues notamment:
our resources
Gas chromatography coupled to mass spectrometry (GCMS)
XRD
FTIR
Scanning Electron Microscopy (SEM)
Nuclear Magnetic Resonance (NMR analysis)
Liquid chromatography coupled to mass spectrometry (LCMS)
ICP-MS
Thanks to its experience and its state-of-the-art analytical facilities (5 200m² analytical laboratory), FILAB laboratory can assist you with your most complex reverse engineering analysis needs, whatever the nature of your sample: aqueous solution, powder, polymer, ceramic, metallic material...
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Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Sectors of activity
Laboratory reverse engineering of a pharmaceutical product
Your needs : to reverse engineer a pharmaceutical product to identify and quantify the substances making up the product
What is reverse engineering ?
Deformulation or reverse engineering of a pharmaceutical product (injectable solutions, drugs, packaging materials…) is a process of analytical decomposition with the aim of separating, identifying and quantifying the substances making up the product, these are the active ingredient (API) and excipients. Reverse engineering requires the use of many different types of chemical analysis.
Why reverse engineer your pharmaceutical products ?
This process is often used in industry for :The development of a new pharmaceutical productComparative analysis between similar products (double sourcing or multi-sourcing) or packaging materialsThe determination of the exact composition of a pharmaceutical productAssessing and verifying the compliance of substances used in a pharmaceutical product compared to an SDS (Safety Data Sheet)Analyzing and identifying an impurity found in a pharmaceutical product
Our solution : to assist you with the process of reverse engineering your pharmaceutical product
The success of this process leads to a better understanding of the product and to the implementation of precise, tailored analytical methods.Equipped with a cutting-edge analytical fleet spread over 5 200m² and working with qualified and experienced partners, FILAB is able to assist you with the process of reverse engineering your pharmaceutical product while providing tailored support.To best assist clients in reverse engineering their products, FILAB uses a variety of techniques :Gas Chromatography paired with Mass Spectrometry (GC-MS)Liquid Chromatography paired with Mass Spectrometry (LC-MS)ICP-MS and ICP-AES spectrometryIon Chromatography (IC)Scanning Electron Microscopy paired with an EDX microprobe (SEM FEG EDX)Nuclear Magnetic Resonance (NMR)Infrared Microscopy (FTIR)…
Our services
Laboratory reverse engineering services
Determine product composition through reverse engineering services
What is reverse-engineering ?
The FILAB laboratory performs Reverse Engineering analysis. Reverse Engineering is a method of determining the chemical composition of a complex mixture by means of various chimical analysis.Reverse engineering enables us to gain a better understanding of a material, its structural problems and its failures. The aim is to improve a material's performance or better target a new supplier.The key to successful Reverse Engineering lies in a thorough understanding of the target application and the use of rigorous analytical methods to characterize the composition of organic and inorganic fractions.
Which matrices are concerned by reverse engineering services?
Our reverse engineering services cover a wide range of matrices: aqueous solutions, powders, polymers, ceramics, metallic materials
Reverse engineering applications ?
Pharmaceutical : analysis of a drug's composition to identify its formulation and excipients.Cosmetics : identification of active ingredients and additives present in a product.Materials : study of the composition of polymers, ceramics or composites to optimize their properties.R&D : inspiration from existing products to create improved formulations.
The FILAB laboratory supports manufacturers in Reverse Engineering services
Why choose FILAB for Reverse Engineering services ?
Thanks to its experience in Reverse Engineering analysis and its state-of-the-art analytical facilities, the FILAB laboratory can assist you with your most complex Reverse Engineering analysis needs, whatever the nature of your sample.Reverse Engineering enables us to meet a wide range of needs, such as :
our services
Analyse and determine the composition of an unknown mixture
Check compliance with a Safety Data Sheet (SDS) or technical data sheet
Compare the composition of several products (double-sourcing or multi-sourcing)
Analyse and identify pollution or impurities
Our reverse engineering services involve a wide range of techniques, some of which are highly specialized :
our technical resources
Gas Chromatography-Mass Spectrometry (GC-MS)
X-ray diffraction (XRD)
Fourier transform infrared spectroscopy (IRTF)
Scanning Electron Microscopy(SEM)
Nuclear Magnetic Resonance (NMR)
Liquid chromatography coupled with mass spectrometry (LC-MS)
Inductively Coupled Plasma (ICP-MS)
Our technical resources
GPC (or SEC) analysis in a laboratory
Your needs : to characterize the size of your molecules using GPC or SEC
What do we mean by GPC/SEC?
Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a characterization technique used to determine the average molecular mass and distribution of molecular masses in a given sample. The dissolved sample is injected in a mobile phase (the eluent) into a column with controlled porosity (called the stationary phase).By using this type of chromatography with a series of detectors (IR, UV, RALS light diffusion, Viscometer), the GPC/SEC technique allows for the exact mass and size of molecules to be determined as well as the intrinsic viscosity of polymer structures to be measured.
How is GPC/SEC used ?
GPC/SEC is an analytical technique used to characterize a wide variety of polymers or other macromolecules found in mixtures.Used in quality control processes, when optimizing a procedure (ex. polymerization kinetics) or as part of an expertise (detection of pollutants or of contaminants…), this technique can meet the requirements of many industrialists in various fields : pharmaceuticals, plastics, chemistry, automobiles, foodstuffs, paints, lubricants, adhesives…
GPC polymer characterization
Gel permeation chromatography (GPC) is a useful technique for polymer characterization. Gel permeation chromatography can be used to analyze copolymer and oligomers. GPC is especially useful for determining molecular weight distributions of polymeric materials, and for monitoring degradation processes. To proceed with polymer characterization, Gel permeation chromatography (GPC) is a valuable technique. Considering its efficacy, gel permeation chromatography is extensively utilized across various industries for polymer analysis. From pharmaceuticals to food packaging, gel permeation chromatography provides an accurate and precise method for measuring the molecular weight distribution of polymer samples. Its ability to separate individual polymers within complex mixtures makes it an invaluable tool for researchers and manufacturers looking to better understand the properties and behavior of polymer materials. With its widespread use and versatility, gel permeation chromatography has become a standard tool for analyzing polymers across a broad range of industries.This technique is particularly important when examining the critical quality attributes of medical products such as bio-pharmaceuticals and vaccines, making gel permeation chromatography an indispensable tool in material science and biomedicine research.
Our solution : to characterize the structure of your macromolecules using GPC/SEC
Our services
From analysis to R&D, FILAB laboratory provides multidisciplinary expertise to fulfil different requests surrounding the GPC/SEC technique :
Inspection of the average molecular mass and distribution of masses in polymer-based materials and substances (Mn, Mw, Mp ?, dispersity index). The NF T 51-505 standard and the ISO 13885 set cover this service.
Structural characterization, namely branching analysis of macromolecular chains
Optimization of manufacturing procedures in order to improve synthesis, application and curing conditions
Defect expertise of thermoplastic parts linked to degradations of the polymeric fraction (shearing of the material leading to chain scission)
Deformulation/Reverse engineering of polymers to understand their physicochemical properties using techniques such as FTIR, TGA, GC-MS, Py-GC-MS, LC-MS…
Protein and polysaccharide characterization (sugars).
For this type of service, FILAB laboratory uses cutting edge analytical techniques such as Gel Permeation Chromatography (GPC/SEC) as well as Gas Chromatography coupled to a Mass Spectrometer after undergoing pyrolysis (Py-GCMS), Liquid Chromatography (LC-MSMS, HPLC…) followed up with other characterization techniques or even chemical analysis techniques (ICP-AES, ICP-MS, IC…).
Why FILAB ?
As an independent laboratory, with a team made up of experienced doctors and engineers, FILAB guarantees the reliability of its results, ensures a quick turnaround for requests and provides tailored support for its clients.
Our FAQ
Why is GPC useful in polymer characterization?
By examining the size, shape, and charge of molecules, laboratories can better understand the properties of polymers, as well as their behavior in various conditions. The technique works by separating molecules with smaller molecules passing through a porous gel matrix more quickly than larger ones.GPC analysis is particularly useful for gaining insights into the structure of complex polymer materials, making it a valuable tool for researchers and manufacturers looking to optimize their materials for specific applications. This type of analysis is essential for creating new materials, improving existing ones, and optimizing production processes. The ability to fine tune polymer properties can have far-reaching implications, from improving medical devices to developing new and advanced technologies.
What industries are concerned with GPC analysis for gpc polymer characterization?
Gel permeation chromatography (GPC) analysis is used across various industries: petrochemicals, biopharmaceuticals, food and beverages, and polymers. Its versatility makes it indispensable for analyzing proteins and biomolecules in pharmaceutical development and quality control.GPC is also used in monitoring process-related changes in polymers, such as those found in adhesives and coatings. In the food industry, it facilitates the analysis of additives, stabilizers, and monitoring product shelf life. The petrochemical sector commonly relies on a GPC for petroleum analysis, fuel quality assessment, and oil spill detection. Moreover, GPC aids researchers in obtaining vital information on product quality within the polymer industry.
What are the advantages of gel permeation chromatography analysis?
GPC offers many advantages including its detection speed, reproducible results, high accuracy and precise size resolution. The technique also requires minimal sample preparation and allows the use of aqueous mobile phases, which can be advantageous when analyzing hydrophobic compounds or sensitive biomolecules. The technique is versatile enough to accommodate a variety of materials such as proteins, polymers and synthetic molecules.
Sectors of activity
Laboratory analysis of luxury goods
Your needs : to design luxury products using high quality materials.
Major brands, manufacturers and subcontractors in the luxury industry are all subject to common priorities and requirements : the pursuit of zero defects, higher production speed, better assembly reliability and the use of high-quality, durable materials.In order to meet these challenges specific to the luxury industry, inspection of the materials used is an essential step. Several factors can affect the life cycle of a luxury product :Defective raw materialsNon-conforming raw materialsAppearance of defects in the final productProblems in the suppliers' production process leading to delays in deliveryetc.For assistance with these industrial challenges you are searching for a reliable, independent laboratory with high added technical value.
Our solution : to offer tailored assistance to luxury industrialists by combining analytics, expertise and counselling on the design of their products.
FILAB laboratory being specialized in analysis and material characterization, has been assisting luxury industrialists in designing and inspecting their products using analytical techniques specific to their needs.Based on experience and its state-of-the-art analytical equipment, FILAB has a wide range of accurate and reliable tools at its disposal to provide the following services :
ANALYSIS
Chemical analysis (raw materials, finished products))
Packaging analysis
Precious metal analysis
REACH analysis
Material characterization : polymers, leather, metals, composite materials, ceramics…
Powder analysis
Surface analysis and coating thickness measurements
Nickel release test
EXPERTISE
Expert chemical analysis
Compatibility studies (container/contents interactions, extractables and leachables)
Pollutant identification using SEB or FTIR
Failure analysis : ruptures, corrosion, coloring and odor problems, etc.
Laboratory audit et analytical training
Deformulation services
R&D
Creation and transfer of analytical techniques
Research into substitutions for allergenic or toxic raw materials
Industrial project development
R&D assistance (Literature review, project management, choice of materials…)
Creation of an innovative product
OUR FACILITIES
Organic analysis : GCMS, Py-GCMS, LC-MSMS, GPC, NMR, FTIR
Mineral analysis : ICP, XRD, IC
Thermal analysis : TGA, DSC
Metallurgic analysis : ICP, SEM-FEG EDX, OES
Powder analysis : XRD, SEM-FEG EDX, BET
Surface analysis : SEM-FEG EDX, PES, TOF-SIMS
Our services
Analysis and characterization of composite materials
Your needs : to verify the quality and the performance of your composite materials as part of the designing process or to improve your products
As major players in the transportation, medical devices or sports equipment sectors, you are looking to optimize your manufacturing processes through the use of lighter and stronger composite materials.The diversity of composite material matrices makes them complex to analyze and requires periodic inspections to verify that they comply with relevant standards.For assistance in overcoming your manufacturing challenges or problems relating to product failures, you are looking for the support of a reliable and responsive laboratory specializing in the analysis and characterization of composite materials.
Our solution : to assist you in analyzing your composite materials and to characterize your problems relating to defects
With a team of experts in materials and an analytical fleet spread over 5 200m², FILAB laboratory provides analysis and characterization services for composite materials to assist you in overcoming your industrial challenges.From the designing process to the improvement of your composite material-based products, FILAB laboratory provides the following services:
Failure analysis of composite materials : aging, ruptures, non-compliances, apparition of deposits or of particulates…
Chemical analysis of the composition of a composite material
Composite material characterization : length, diameter, morphology…
Deformulation/Reverse engineering services
To achieve this, our laboratory has a Scanning Electron Microscope, coupled to an EDX probe, as well as numerous GC-MS and Py-GCMS machines to study the composition of composite materials (carbon fiber, fiberglass, ceramic...).Additionally, TGA thermal analysis coupled to FTIR will highlight the physicochemical properties of the composite material depending on temperature.
Sectors of activity
Tests and analysis for the aeronautics industry
Your needs: to design reliable and efficient aeronautical equipment
As major players or subcontractors in the aeronautics or space industries, the quality and reliability of your materials and equipment are paramount to ensure the security of the goods or the comfort the people being transported.Studying your materials and aeronautical equipment will allow you to increase the performance of your materials (lifespan, weight, noise output) and to optimize your costs (price of materials, maintenance) all while complying with environmental norms.These challenges prompt you to seek help from a responsive and reliable laboratory offering high added technical value.
Our solution : to assist our clients in the aeronautics industry with analysis and with the development of new materials
FILAB is an independent laboratory situated in the French city of Dijon and is made up of a team of 63 people, including doctors and engineers.FILAB has been approved by SAFRAN for chemical analysis of metal alloys or of mineral products relating to aeronautics.With an analytical fleet spread over 2100m² and extensive experience in assisting as part of projects in the aeronautics or space industry FILAB can offer the following services :
ANALYSIS
Chemical analysis : fluids, industrial oils, resins…
Metallic alloy inspection
Surface analysis and coating thickness measurement
Determination of trace amounts and impurities (heavy metals)
Analysis in relation to a regulatory compliance study (AS9100 standard)
Material characterization : polymers, composites, metallurgical analysis
Powder analysis
Thermal analysis
Analysis of leachable volatile organic compounds using GC-MS and HS-GCMS
EXPERTISE
Accelerated aging tests
Deformulation/Reverse engineering services
Failure analysis : fissures, contaminant or particle analysis, adhesive problems, corrosion, metallographic examination, weld analysis…
Assistance in getting cleaning procedures validated
Identification of unknown pollutants
Regulatory compliance testing (container/contents interactions, extractable and leachable substances)
Analytical training and laboratory audits
R&D
Creation and transfer of new analytical methods
Research into substitutions for carcinogens
Literature reviews
Development of a new chemical formula or of a new material
OUR FACILITIES
Organic analysis : GCMS, Py-GCMS, LC-MSMS, GPC, NMR, FTIR
Thermal analysis : TGA, DSC
Powder analysis : XRD, FEG-SEM-EDS, BET
SIMS analysis
Mineral analysis : ICP analysis, XRD analysis, IC
Metallurgical analysis : ICP, FEG-SEM-EDS, SEO
Surface analysis : FEG-SEM-EDS, PES, TOF-SIMS
Our services
Chemical analysis for paint and varnish testing in a laboratory
Your needs : to do a paint or varnish testing, to characterize a defect found in a batch of industrial paint or varnish
What is industrial paint made of ?
Paint or varnish is liquid mixture allowing for the surfaces of industrial products to be protected, dyed or improved. Paint is generally made up of 3 main components :- The pigment (dye and opacity)- The binder, giving the paint its consistency and transparency- The solvent, allowing for easier application as a liquid. Once the paint is applied the solvent evaporates and the paint hardens.Other ingredients can be added to strengthen the paint’s resistance to outside influencesPaint is generally applied in multiple layers on a smooth, clean surface.
Why analyze a paint or vanish ?
The chemical analysis of a paint or varnish can have different goals :- to verify that the product is compliant with relevant standards- to analyze the chemical composition of a paint or varnish- to reverse engineer a varnish- to study a defect or product failure after paint or varnish was appliedAnalysis and testing of paint or varnish can in fact be needed after a defect is detected on a product’s surface (stain, adhesive problems, scales, color change…). After the identification process, analysis allow for the origin of the defect to be characterized.The application of paint or varnish must abide by a scope statement in line with standards and regulations or industrial requirements, with particular attention given to :- The quality of raw materials being used to make the paint- The desired characteristics of the finished product- The quality of the coating faced with different outside constraintsAssistance from an analytical laboratory will allow you to ensure that the paints and varnishes you use are in compliance with relevant standards.
Our solution : to analyze the quality of your paints and varnishes and to provide you with tailored solutions to optimize their characteristics
Our services
Relying on extensive experience in analytical chemistry, FILAB laboratory can provide analysis and testing services for your industrial paints and varnishes, adapted to your requests :Conformity analysis of your paints and varnishesPigment analysisImpurity and contaminant detectionAdvice in the choice of paintsVarnish, paint and polymer stress testingLead and heavy metal analysis of paintsVOC analysis (Volatile Organic Compounds)Deformulation/Reverse engineering services These chemical analysis are performed using different techniques :Gas chromatography coupled with mass spectrometry (GC-MS)Scanning electron microscopy (SEM-FEG-EDX)Optical microscopyThermal analysis (DSC)Infrared spectrometry (FTIR)ICP-AES and ICP-MSMS spectrometry
Why FILAB ?
As an independent laboratory, with a team made up of experienced doctors and engineers, FILAB guarantees the reliability of its results, ensures a quick turnaround of requests and provides tailored support for its clients.For more information about our analysis of paints and varnishes, feel free to contact us
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Our services
Analytical Chemistry Laboratory
Your needs : to inspect and analyze the chemical substances that make up your products
What is analytical chemistry ?
Analytical chemistry refers to a whole field of chemistry aimed at analyzing and characterizing a product or a substance in order to understand its properties. Analytical chemistry can use qualitative chemical analysis (identification and characterization of a compound) or quantitative analysis (measurement of the concentration or dosage of a compound).
Our solutions: a high added-value analytical chemistry service
FILAB's analytical chemistry laboratory is equipped with the latest and most varied analytical equipment, and can offer you tailor-made support in the control of your raw materials and finished products. From quality control analysis to the development and validation of analytical methods, our expertise and multi-disciplinary skills enable us to respond to any type of request in analytical chemistry.
Our chemical analysis services
Composition and purity analysis
Determining the chemical composition of samples
Identification d'impuretés et de contaminantsIdentification of impurities and contaminants
Measuring the purity of raw materials, intermediate and finished products
Pharmaceutical quality control
Stability testing on drugs
Validation of analytical methods in accordance with regulatory standards (FDA, EMA, etc.)
Analysis of the release of active ingredients
Characterization of materials
Analysis of polymers, composites, metals and ceramics
Determination of electrical and mechanical properties
Surface and interface studies, thermal analysis
Research and development
Synthesis and characterization of new chemical compounds
Development of formulations
Chemical process optimisation
our technical resources
Gas chromatography (GC-MS, GC-MS/MS, HS-GCMS, GC-FID UV)
Gel Penetration Chromatography: GPC/ SEC
SEM-EDX
Liquid chromatography (HPLC-MS/MS , HPLC-CAD, LC-QTOF, LC-UV, LC-Orbitrap, LC-ELSD, LC-RI)
Elementary analysers: CHONS
NMR
FILAB, analytical chemistry laboratory
Why choose FILAB for your analytical chemistry analysis?
In a demanding industrial environment, guaranteeing the purity, stability and conformity of products is essential. Impurities, variations in raw materials or instability in formulations can have an impact on their performance and their marketing.Using an analytical chemistry laboratory enables chemical substances to be identified, quantified and characterised with precision. FILAB supports you in quality control, regulatory validation and process optimisation, ensuring reliability and compliance.FILAB, an analytical chemistry laboratory, specialises in the use of chemical analysis techniques and methods to determine the composition, structure and quantity of substances.Our expertise enables us to meet various objectives:
Qualitative analysis: Identifying the components of a sample, to find out which substances are present.
Quantitative analysis: measuring the quantity or concentration of substances in a sample
Characterization of compounds: Determining the chemical structure and physical properties of compounds, to understand the behaviour and potential interactions of substances.
As an independent analytical chemistry laboratory with a team of experienced doctors and engineers, FILAB guarantees the reliability of your results, ensures rapid processing of requests and provides personalised support for its customers.
Where can a chemical product be analysed?
To guarantee the quality, safety and conformity of your products, it is essential to carry out chemical analyses in a specialised analytical chemistry laboratory. FILAB uses state-of-the-art equipment and proven methodologies to identify, quantify and characterise the substances present in your samples. As an independent laboratory, FILAB can help you analyse your chemical products, whether raw materials, formulations, residues or impurities. Using advanced techniques (chromatography, spectrometry, microscopy, etc.), we provide you with reliable results that comply with current regulations.
Why is analytical chemistry used ?
Mostly used as part of quality control, as part of compliance studies following a product failure (trace residues, discoloration, odor problems…), analytical chemistry has taken an important place in various industrial fields. Identifying toxic residue or an impurity in abnormal proportions can lead to a momentary cease in production or in some cases can lead to a product being called back after being put on the market.Analytical chemistry can also be used to improve the performance of a substance or product by studying its behavior when subjected to various exterior phenomena (temperature, light…) Regularly inspecting the consistency of products has become essential ; laboratories specialized in analytical chemistry such as FILAB are here to assist you with these endeavors : to ensure your product’s quality, performance and safety.
More about analytical chemistry
Our analytical chemistry methods and services
Our analytical chemistry techniques can be used to perform qualitative or quantitative analyses, with varying degrees of invasiveness and sample destruction.Analytical chemistry techniques encompass a range of methods for detect, identify, characterise and quantify chemical substances.FILAB's analytical chemistry methods are particularly useful in the context of support for research and development, and for the quality control of pharmaceutical products.However, the applications of these methods are diverse, encompassing the different stages in the life cycle of an analytical method.Selecting a laboratory with the necessary expertise to develop these methods is often a challenge for industries.
FAQ
What is analytical chemistry?
Analytical chemistry is a branch of chemistry whose aim is to identify and quantify the chemical compounds present in a substance. It includes techniques and methods for analysing the chemical composition of samples, whether for qualitative applications (determining the components) or quantitative applications (measuring the quantities of these components).
What analysis techniques are used in analytical chemistry?
In analytical chemistry, various techniques are used, such as spectrometry, chromatography, titration and other methods, to obtain precise information about chemical substances.
Why should manufacturers use analytical chemistry?
Manufacturers may need to use analytical chemistry in a number of different situations:Quality control: analytical chemistry is used to ensure that raw materials, intermediate products and finished products meet the required quality standards. It ensures regulatory compliance and customer satisfaction.Product development: this discipline is essential for the research and development of new chemical, pharmaceutical and cosmetic products. It is used to characterise components and optimise formulations.In a manufacturing process, it aims to monitor chemical reactions and process parameters. It aims to improve the efficiency, safety and profitability of industrial production.Safety of pharmaceutical products: in the pharmaceutical sector, analytical chemistry is crucial for verifying the purity, safety and efficacy of products.Materials control: industries using metals, polymers or composite materials can use analytical chemistry to guarantee their quality and performance.
What are the analytical chemistry methods?
Analytical chemistry is a branch of chemistry dedicated to the analysis of chemical substances. It is used to identify the chemical composition of samples and measure their quantity.Different methods are used to analyse substances, including mass spectrometry, chromatography, infrared spectroscopy and thermal analysis. The results obtained are invaluable for a variety of disciplines, including medicine, the pharmaceutical industry, agriculture and scientific research.
What properties are measured in analytical chemistry?
In analytical chemistry, a variety of properties are measured and analysed. They include the concentration of molecules in a sample, the composition of the substance, its structure, molecular weight, pH, density and electrical conductivity.These properties are essential for understanding the nature of a substance and carrying out accurate quantitative and qualitative analyses. Analytical chemistry is therefore an important branch of chemistry with applications in many fields, from the production of medicines to environmental protection and the analysis of food products.
What are the applications of analytical chemistry?
Analytical chemistry is a fundamental discipline in chemistry. Laboratory analysis is used to determine the precise chemical composition of samples, whether liquid, solid or gaseous, in quantitative or qualitative terms.Analytical chemistry has a wide range of applications, from the characterisation of raw materials to the detection of pollutants or pathogens. The industries using these laboratory analyses are extremely diverse: cosmetics manufacturers, drug producers, water treatment companies, and many others. Analytical chemistry plays a crucial role in many areas, contributing to product quality and safety.
How complex is analytical chemistry?
The complexities of analytical chemistry include the need to choose the right tools and techniques for each analysis, the need to understand how environmental variables can affect the results and the need to verify and validate data before using it. Our FILAB experts in analytical chemistry guarantee the rigour and reliability of the analyses and results.
Sectors of activity
Laboratory analysis of active ingredients for the pharmaceutical industry
Your needs : to analyze and determine the active ingredient contents in your products to meet regulatory requirements
An active pharmaceutical ingredient (API), also called active substance are the substances in medication which given them their biological and therapeutic properties. From natural (mineral, animal or vegetal) or synthetic origins, active ingredients are completed by excipients which give the medication its flavor, shape or even color.Just like excipients, active pharmaceutical ingredients (APIs) are subject to important regulatory constraints in order to avoid any risk of toxicity for the consumer. For this reason, pharmaceutical companies and industrial suppliers must regularly inspect the quality of their active ingredients in order to remain in line with regulatory changes.
Our solution : to provide you with our expertise and our technical facilities to analyze the active ingredients of your pharmaceutical products
As an independent laboratory situated in Dijon, France, FILAB has been active in the pharmaceutical industry for over 30 years by performing compliance checks and inspecting raw materials used in medication.From the designing process to production, all the way to the product being put on the market, FILAB can assist you in properly carrying out your industrial projects, abiding by security standards. These are a few examples :ICP determination of active ingredient contentsCharacterization of active ingredients using GC-MS, NMR, LC-MS/MS…Detection of elemental impurities in pharmaceutical products in accordance with the USP 233 standard (ICH Q3D)Stability and compatibility studiesDevelopment of analytical methods of determination in accordance with relevant referencesDeformulation/reverse engineering of finished productsBy guaranteeing a quick turnaround for your requests, FILAB supports pharmaceutical industrialists with their needs for complex chemical analysis as well as with their R&D projects (literature review, scope statements, substitution research, synthesis…)
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Our services
Analytical laboratory
Your needs: to analyze and inspect the chemical substances which make up your raw materials and finished products
Why conduct chemical analysis?
The rise of international competition and complication of regulations incite industrialists to optimize the performance of their products by better understanding the products physicochemical properties. To achieve this, analytical chemistry can be used to obtain quantitative (concentration and determination of compounds) or qualitative (overall chemical nature of a compound) analysis of the product.As part of quality control, of regulatory compliance or following the discovery of a product failure, analytical chemistry plays an essential role in all sectors of industry.Our laboratory, being specialized in chemical analysis and equipped with state-of-the-art analytical techniques, is here to assist you in your endeavors.
Our solution: to assist industrialists in overcoming their challenges by providing chemical analysis with high added value
Thanks to its highly trained team the FILAB laboratory can offer a multitude of analytical services to inspect your raw materials or finished products.
OUR ANALYTICAL SERVICES
Custom chemical analysis
REACH analysis
Elemental analysis
Chemical analysis of polymers, composite materials, metallic materials and ceramics
Heavy metal analysis
Biocompatibility analysis in accordance with ISO 10993
Bisphenol A analysis
Analysis of cleaning product residue on medical devices THC/TOC
Deformulation services
ISO 17025 accredited laboratory
Raw material analysis (impurity detection)
Industrial analysis
Contamination or pollutant analysis
Chemical analysis following a product failure
Surface treatment bath analysis
Analysis of phthalates and of DEHP
Residual solvent analysis
Granulometric analysis
Development and validation of new analytical techniques
Paint/Varnish analysis
OUR FACILITIES
GC-MS, HS-GCMS (Gas chromatography)
ICP-AES, ICP-MS
DSC
IC (Ionic chromatography)
HPLC-MS/MS, HPLC-DAD (Liquid Chromatography)
FTIR (Infrared spectroscopy)
UV-Vis spectrometry
SEM-EDX (scanning electron microscopy)
With three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Our services
Laboratory analysis of additives
Your needs : to analyze the different properties and the performance of an additive by studying its composition
An additive is a chemical substance added to the composition of a material or product to improve its final properties. It is important to distinguish food additives (dyes, preservatives, sweeteners) from polymer additives (heat resistance, elasticity, plasticity…) and from additives put into industrial paints and varnishes.As part of the development or optimization processes of a product, of changes in regulations, or following a product failure, you are looking to characterize and determine the additive contents of your products with support from a specialized laboratory.
Our solution : to provide you with our analytical equipment and the expertise of our engineers for your analysis and for the optimization of your industrial additives
Thanks to the fact that our facilities complement each other well and our dual expertise in chemistry and materials science, FILAB can perform physicochemical analysis to characterize the presence of additive in your industrial materials :Determination of the additive contents of a productInspection of the composition of a product compared to its SDSAccelerated aging tests on products containing additivesProduct reverse engineering to determine the presence of additivesAnalytical development and validationTo provide these services, FILAB laboratory uses a wide range of analytical techniques :DSC or ATG thermal analysisChromatographical analysis (GC-MS or HPLC) to identify volatile additivesSpectrometric analysis (FTIR, ICP-MS and ICP-AES) to measure the presence of an additive in a polymerWith three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Sectors of activity
API testing in a laboratory
Your needs : to verify that your APIs comply with relevant standards and regulations
APIs, or active pharmaceutical ingredients, are substances contained in drugs that are responsible for the health benefits they bring to the patient.Subject to numerous international regulations, including ICH Q7, the quality and safety of APIs is a primary requirement for any pharmaceutical manufacturer to get their product to market.In light of this, the use of a specialized inspection laboratory guarantees compliance with standards, efficiency and safety of your pharmaceutical products.
Our solution : to provide you with our methods and our technical facilities to be able to characterize your active pharmaceutical ingredients
For 30 years, the laboratory has been assisting manufacturers in the pharmaceutical industry with analysis, inspections and the development of reliable and compliant products.From analysis to project management, FILAB provides the following services :API analysis using GC-MS, NMR or LC-MSMSInspections of finished productsAPI compatibility and stability testingDetection of elemental impurities in pharmaceutical products in accordance with USP 233Development of new analytical procedures for determining API contents in accordance with relevant standardsDeformulation/Reverse engineering of finished productsFILAB provides direct technical support to answer all your questions and to guarantee a quick turnaround of your requests.
Our services
Laboratory analysis of biological medicine
Your needs: to ensure a high level of quality for your biological medicine in accordance with relevant pharmaceutical standards
Biological medicines are medications with active ingredients taken from living sources. They differ from conventional medications as their active ingredients are not chemically synthesized.Biological medicines encompass vaccines, therapeutic proteins and monoclonal antibodies which are often administered in the form of injectable drugs.These biological medicines are subject to the same types of stringent regulations as conventional medicines. Many chemical analysis must therefore be carried out on these substances.Compliance of biological medicines is critical for them to be able to go to market and is essential for their life cycle.A poorly aging product, the presence of impurities, interactions between active ingredients and excipients… These scenarios all hinder a biological medicine’s chances of going to market and can cause them to be called back.To overcome these technical challenges, you are looking to cooperate with a reliable and reactive analytical laboratory.
Our solution: to assist you in expertly analyzing your biological medicine and monitoring its quality
FILAB offers its high level of skill and its advanced technical know-how along with a cutting-edge analytical fleet to pharmaceutical industrialists by providing services fulfilling various compliance requirements. FILAB is the only laboratory in France to be ISO 17025 accredited (www.cofrac.fr accreditation n°1-1793) for carrying out analysis of elemental impurities found in pharmaceutical matrices.From analysis to R&D, FILAB laboratory is able to provide its expertise to fulfil various types of requests relating to biological medicines :Chemical analysis of biological medicines using GC-MS, LC-MS, ICP…Detection of elemental impurities (ICH Q3D)Particulate analysis (troubleshooting) using SEM-EDX, FTIR, LC-MS/MS…Reverse engineering of biological medicinesE&L testingAnalytical developmentValidation of methods in accordance with ICH Q2Analysis of residual solvents found in pharmaceuticals in accordance with the ICH Q3D guidelineNitrosamine analysis For more information about our analytical services relating to biological medicine, feel free to contact us via email at contact@filab.fr or over the phone by calling +33 (0)3 80 52 32 05. You can also request a free quote online here.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Our services
Laboratory analysis and determination of D4 and D5 siloxane content
The analysis of D4 and D5 siloxanes at FILAB is important for industries utilizing these chemicals, especially in cosmetic products. Employing advanced gas chromatography and other analytical techniques, FILAB's services ensure that products comply with environmental and safety standards. This chemical analysis process is vital for confirming that siloxane levels in products are within legal and safe limits, supporting both product safety and environmental sustainability.
Your needs: to monitor the use of D4 and D5 siloxane in your production processes
What do we mean by Siloxanes?
The name Siloxane is derived from Silicon, Oxygen and alkane. They are a family of chemical substances composed of primarily of silicon. Usually found in cosmetic products, (makeup, crème, deodorant…) and in cleaning as a whole, in paint, etc. They are used for they particular chemical properties: they are odorless, colorless, non-greasy, easy to apply and dry rapidly.This family encompasses multiple categories of substances: Cyclotetrasiloxanes (D4), Cyclopentasiloxanes (D5) and Cyclohexasiloxanes (D6). The term “silicone” can also be used to refer to siloxanes.
Why analyze siloxanes?
Found in some household products, humans can de exposed to siloxanes through skin contact or by inhalation. D4 siloxanes have been classified as endocrine disruptors by the European Union due to their suspected toxicity to the human reproductive system. However, risks linked to the use of cosmetic products containing D4 siloxanes has not yet been proven. Regarding D5 siloxanes, regulatory authorities consider its use to be risk free.Ecological concerns have been raised surrounding the use of these two substances; D4 and D5 siloxanes are suspected to be toxic to aquatic life due to the fact that they are not biodegradable in water or living tissue.The monitoring of scientific advances relating to the use of siloxanes and their impact on human and environmental health is an important topic in the cosmetics industry. Therefore, support from a specialized laboratory will allow you to adapt your production procedures to stay in line with changes in regulations.
Our solution: to reliably analyze and quantify the presence of D4 and D5 siloxane in your finished products to asses the risk they pose
Our analytical services for D4/D5 siloxanes
Thanks to the know-how of its team and its cutting-edge analytical fleet, FILAB laboratory is able to assist companies with analysis of D4 and D5 siloxanes and in verifying that their products comply with standards:Determination and analysis of siloxane contents in your productsAnalytical development and validation of methods for determining content in accordance with relevant ISO standardsR&S assistance: product substitution, reverse engineering, literature review…D4 and D5 siloxanes are analyzable using gas chromatography (GC-MS) due to their volatility. Being organic compounds, it is possible to determine their structure using Nuclear Magnetic Resonance (NMR).
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
What are the restrictions regarding D4 et D5 siloxane content?
In Europe, the use of D4 siloxane (octamethylcyclotetrasiloxane) and D5 siloxane (decamethylcyclopentasiloxane) in wash-off cosmetic products is restricted by the European Chemicals Agency (ECHA) due to their potential environmental impact. The restriction applies to leave-on products that are intended to stay on the skin or hair, as well as wash-off products that are applied to areas of the body where they may be washed off and enter the environment. However, the restrictions do not apply to rinse-off products where the product is immediately rinsed off the body, such as shampoos and soaps. The restrictions are based on the potential for these compounds to bioaccumulate in aquatic organisms and their tendency to persist in the environment. The use of D4 siloxane and D5 siloxane in other consumer products, such as adhesives, sealants, and coatings, is not restricted in Europe, although their use is subject to evaluation and may be restricted in the future if they are found to pose a risk to human health or the environment.
What are the risks if you do not perform D4 and D5 siloxane analysis?
The fines that companies could face for violating regulations regarding siloxanes in cosmetics and other products can vary depending on the specific country and regulations involved. In Europe, the fines may be imposed by the national authorities responsible for enforcing cosmetic regulations, such as the European Chemicals Agency (ECHA).If a company is found to be in violation of these regulations about siloxane analysis, they may face fines, as well as other legal consequences like product recalls or injunctions. The fines can vary widely depending on the severity of the violation and the specific country involved.For example, in France, violations of the country's cosmetic regulations can result in fines of up to €150,000 and two years of imprisonment. In the UK, fines for violating cosmetic regulations can reach up to £20,000 per offense.It's important to note that the fines are not the only potential legal consequence for companies. If a consumer is harmed by a product that contains excessive levels of D4/D5 siloxanes or other harmful substances, the company could also face lawsuits, damages, and reputational harm.To avoid fines and other legal consequences, it's crucial for companies to comply with all relevant regulations and conduct proper testing and siloxane analysis of their products. To make sure your products comply with the regulations of your country, contact Filab to advise you and perform your analysis.
How to perform siloxane analysis?
Siloxane analysis can be performed using a number of different analytical techniques, depending on the specific application and desired level of sensitivity. Here are some commonly used methods: Gas chromatography-mass spectrometry (GC-MS): This is a widely used method for analyzing D4 and D5 siloxanes in environmental and personal care products. It involves separating the siloxanes from the sample matrix using gas chromatography, and then identifying and quantifying them using mass spectrometry. Liquid chromatography-mass spectrometry (LC-MS): This method is similar to GC-MS, but uses liquid chromatography instead of gas chromatography to separate the siloxanes from the sample matrix. It is often used for analyzing siloxanes in biological samples, such as blood or urine. Fourier transform infrared spectroscopy (FTIR): This method measures the chemical bonds between atoms in a sample, and is often used for analyzing siloxanes in silicone-based materials, such as medical devices or industrial coatings. Nuclear magnetic resonance (NMR) spectroscopy: This method uses the magnetic properties of atomic nuclei to identify and quantify siloxanes in a sample. It is often used for analyzing complex mixtures of siloxanes, such as those found in silicone oils or greases. Solid-phase microextraction (SPME): This method involves extracting siloxanes from a sample matrix using a small, coated fiber, which is then analyzed using GC-MS. It is often used for analyzing volatile organic compounds in air or water samples.Each of these methods has its own advantages and limitations, and the choice of method will depend on the specific application and requirements of the analysis.
What are the specificities of D5 and D4 siloxane in cosmetics?
Siloxanes are commonly used in cosmetics due to their unique properties, but there are concerns about their potential impact on human health and the environment. Here are some specificities of siloxanes in cosmetics and why analyzing their content within products is important: Potential toxicity: Some research has suggested that certain siloxanes, like D4 and D5, may have endocrine-disrupting effects and could potentially be harmful to human health. This is a concern for products that are applied directly to the skin or mucous membranes, such as lipsticks or vaginal creams. Environmental impact: Siloxanes can have a negative impact on the environment, particularly when they are released into waterways through the use of wash-off products. Siloxanes like D4 and D5 have been found to bioaccumulate in aquatic organisms and can persist in the environment for long periods of time, which can have cascading effects on ecosystems. Regulatory restrictions: Due to these concerns, siloxanes like D4 and D5 are subject to regulatory restrictions in some regions, particularly in Europe. Analyzing the content of these compounds within cosmetic products can help ensure compliance with these regulations and provide consumers with information about the safety and environmental impact of the products they use. Product formulation: Analyzing the content of siloxanes within cosmetic products is also important for product formulation. Different types of siloxanes have different properties and may be more or less suitable for different types of products. Analyzing the content of siloxanes within a product can help ensure that it performs as intended and meets consumer expectations. Analyzing the content of siloxanes within cosmetic products is important for ensuring the safety and environmental impact of these products, as well as for product formulation and compliance with regulatory requirements.
Sectors of activity
Excipient analysis laboratory for the pharmaceutical industry
Your needs : to reliably analyze excipients found in your pharmaceutical products to meet regulatory requirements
Used in the pharmaceutical and cosmetics industries, an excipient is the name given to any substance present in a product that is not the active ingredient. While not having intrinsic therapeutic properties, excipients will give the final product new properties such as greater stability, better taste, a more desirable color, a different shape, etc.
To avoid any risks of chemical interactions or even toxic reactions, excipients are subject to stringent regulatory constraints especially as some of them can trigger allergies or intolerances (lactose, aspartame, formaldehyde, mannitol, wheat starch)
Pharmaceutical laboratories and excipient suppliers must verify that their excipients comply with relevant standards (detection of impurities) as well as evaluating their compatibility with the active ingredient, packaging and final use of the product. To achieve this, support from a laboratory specialized in analyzing active pharmaceutical ingredients will allow you to carry out regular inspections to ensure that your excipients stay in line with changing regulations.
Our solution : to provide you with the tools and experience needed to quickly and reliably evaluate your excipients
For over 30 years, FILAB has had the experience and specific analytical fleet needed to be able to assist pharmaceutical companies in analyzing their substances and excipients, all while providing tailored support.
From analysis to analytical development, FILAB can support your industrial projects while abiding by safety standards by providing the following services :
Excipient characterization using GC-MS, LC-MS/MS, NMR…
ICP-AES and ICP-MS screening and determination
Particulate or contaminant analysis of excipients
Detection of elemental impurities in excipients in accordance with the USP 233 (ICH Q3D)
Compatibility testing between active ingredients and excipients
Analytical development and validation of methods for determining excipient contents in accordance with relevant standards (ICH, USP, EP, ISO...)
Reverse engineering of finished products
Our technical resources
LC MS and HPLC MS analysis in the laboratory
Your needs : to analyze active substances or impurities in your products using HPLC or LC-MS
In the pharmaceutical, cosmetics and chemical sectors, the detection and identification of trace compounds helps to guarantee the conformity, safety and performance of products.Using LC MS or HPLC MS analysis, liquid chromatography coupled with mass spectrometry, our laboratory provides an analytical solution tailored to complex matrices and the most stringent regulatory requirements.
What is HPLC MS?
HPLC-MS: High Performance Liquid Chromatography (HPLC) coupled with Mass Spectrometry (MS) is used to identify and quantify non-volatile organic substances in various matrices.It is a particularly useful technique for analysing cosmetics and pharmaceutical products in the laboratory, although it can be applied to all industries.
What is LC MS analysis?
LC-MS (Liquid Chromatography-Mass Spectrometry) is a powerful analytical technique that combines the separation capabilities of liquid chromatography (LC) with the chemical analysis capabilities of mass spectrometry (MS).Liquid chromatography (LC) is used to separate the different components of a mixture. In LC, the sample is dissolved in a solvent and passed through a column containing a stationary phase. The different compounds in the sample interact with this material in different ways and move at different speeds, enabling them to be separated.Mass spectrometry (MS): after separation by LC, the compounds are analysed using this technique, which identifies the compounds by measuring the mass/charge ratio of their ions. The ions are separated according to their mass and charge. The mass spectrometer then produces a spectrum that can be used to determine the molecular mass of compounds and to identify their chemical structure.
Analysis of impurities by LC MS or HPLC MS
Impurity analysis using LC-MS (Liquid Chromatography-Mass Spectrometry) or HPLC-MS (High-Performance Liquid Chromatography-Mass Spectrometry) is a technique used in many fields, particularly in the pharmaceutical industry.The combination of LC and MS allows specific analysis of complex mixtures. These methods are used to detect, identify and quantify impurities or contaminants present in a sample.
Our solutions: liquid chromatography analysis (LC and HPLC) coupled with an MS or MS/MS detector
For over 30 years, our FILAB laboratory has had the experience and specific analytical equipment to support companies in LC MS or HPLC MS analysis for the control of raw materials or finished products through tailor-made support.
LC-MS or HPLC-MC: state-of-the-art equipment
Liquid chromatography (HPLC) coupled to a mass (MS) or mass-mass (MS-MS) detector is used to determine the purity of raw materials or compounds in a sample.LC MS analysis in the laboratory enables precise identification and quantification of compounds in complex samples. From the pharmaceutical sector to the chemical industry, our state-of-the-art LC-MS equipment is the solution of choice for the detection of impurities and contaminants to the characterisation of new compounds. When you choose our laboratory for your LC-MS analysis needs, you benefit from cutting-edge technology and expertise in impurity analysis.
The advantages of LC MS or HPLC MS analysis
LCMS or HPLCMS analysis uses chromatography coupled with spectrometry.
This combination of two cutting-edge technical resources offers high sensitivity in the identification and quantification of components and impurities.
HPLC efficiently separates compounds, while MS provides precise identification based on molecular weight and structure.
This approach is particularly useful for analysing complex samples where impurities are present in very low concentrations.
Our services using LC MS or HPLC MS
LC MS - HPLC MS
Dosage of active ingredients
Impurity analysis
Development of analytical methods
Validation of analytical methods
Deformulation analysis
Why use an LC-MS analysis laboratory?
Liquid chromatography coupled to mass spectrometry (LC-MS) is a state-of-the-art technique for identifying, quantifying and characterising organic or organometallic compounds, even at trace levels (ng/mL or less).It is essential when it comes to analysing complex matrices or validating the conformity of products and materials in demanding industrial contexts.
Applications of lc-ms analysis
Our other technical resources
HPLC UV analysis
LC CAD analysis
Pic unknown analysis
What is LC-MS analysis?
Liquid chromatography-mass spectrometry (LC-MS analysis) is a powerful analytical technique used to identify and quantify different compounds in complex samples. By separating and identifying the components of a sample, LC-MS analysis can provide detailed information about the composition of a sample, such as its identity, concentration, structure and other characteristics. LC MS analysis is used in sectors ranging from drug development to environmental monitoring. The method involves separating the components of a sample using liquid chromatography before analysing them using mass spectrometry to identify them. The data obtained from an LC-MS analysis is often used to verify the purity or quality of compounds or to obtain quantitative data for comparing samples. LC-MS analysis can be used to measure small quantities of substances such as drugs, toxins, hormones and metabolites in biological samples. It is also used to look for contaminants in food and drink products, detect traces of toxic chemicals in the environment and analyse the contents of pharmaceutical products.As well as providing important analytical data, LC-MS analysis is increasingly being used for diagnostic purposes, notably to detect metabolic disorders or identify biomarkers associated with certain diseases. Its use for diagnostic purposes could revolutionise healthcare by providing clinicians with powerful tools for the early detection and treatment of disease. By providing detailed information about the composition of a sample, LC-MS analysis can prove invaluable to research and development efforts, helping researchers to identify new compounds or better understand existing ones.
What are the differences between LC MS and MSMS analysis?
The main difference between LC-MS and MS/MS analysis is that LC-MS involves the separation of compounds by liquid chromatography before they are analysed by mass spectrometry, which is not the case with MS/MS. In LC-MS, the components of a sample pass through a stationary phase (such as a column) to separate them before being analysed by mass spectrometry. In MS/MS analysis, on the other hand, the compound passes directly into the mass spectrometer without first being separated. This results in faster analysis and greater sensitivity than LC-MS. However, because it involves no preliminary separation step, MS/MS analysis cannot provide detailed information about the composition or structure of the sample. It is mainly used for qualitative analysis.
Why use our laboratory for LC MS or MSMS analysis?
At the Filab laboratory, we offer state-of-the-art LC-MS and MS/MS laboratory analysis services to meet our customers' needs. Our experienced team is committed to providing you with accurate and reliable results in the shortest possible time. Our LC-MS laboratory is at your disposal for any requests you may have.
Differences between LC-MS and HPLC-MS techniques
The main difference between LC-MS and HPLC-MS lies in the type of liquid chromatography used.In HPLC, resolution and separation efficiency are generally higher than in traditional LC methods. This is due to the use of finer columns, smaller stationary phase particles and higher operating pressures in HPLC. HPLC-MS is often preferred in situations where high sensitivity and precision are required, such as in the analysis of trace contaminants.
Our services
Chemical analysis of industrial adhesives in a laboratory
Your needs : to analyze an industrial adhesive or to characterize a defect found in a regular or industrial adhesive
What is an industrial adhesive used for ?
An adhesive is a bonding agent used in industrial manufacturing processes to assemble different metallic or plastic parts together. The efficiency of an adhesive is directly linked to its composition, it must therefore meet certain criteria :Resistance to traction and movementResistance to outside constraints (joint seals) over timeCure time optimization based on industrial processes
Why analyze an adhesive or an industrial adhesive ?
Chemical analysis of an adhesive can be useful for various reasons :To verify that an adhesive is compliant with safety data sheetsTo analyze its chemical compositionTo study its behavior in any given conditionsTo study a defect or product failure following the application of an adhesiveAnalysis and characterization of an adhesive can be needed after a defect is found in the way a product is assembled (adhesive problems, disbonding, trace residues…) Analytical methods allow for the origin of the defect to be characterized and to determine whether it is due to the composition of the adhesive or the state of the product’s surface.Assistance from an analytical laboratory will allow you to ensure that your products are in compliance with relevant standards.
Our solution : to analyze the quality of your adhesives and to provide you with tailored solutions to optimize their characteristics
Our adhesive analysis services
Relying on extensive experience in analytical chemistry, FILAB laboratory can provide analysis and characterization services for adhesives, adapted to your requests :Conformity analysis of the adhesive’s compositionImpurity and contaminant detection in your adhesivesAdvice in the choice of adhesive (double sourcing, stress testing)Deformulation/Reverse engineering servicesCuring time optimization using DSCDisbonding expertise Coupled with surface analysis, our adhesive analysis services are carried out using various techniques :Gas chromatography coupled with mass spectrometry (GC-MS)Scanning electron microscopy (SEM-FEG-EDX)Optical microscopyThermal analysis (DSC)Infrared spectrometry (FTIR)ICP-AES and ICP-MSMS spectrometry
Why FILAB ?
As an independent laboratory, with a team made up of experienced doctors and engineers, FILAB guarantees the reliability of its results, ensures a quick turnover for requests and provides tailored support for its clients.
Sectors of activity
Laboratory analysis of glass and fiber glass
Your needs : to design glass materials or bottles that are both of high quality and safe
Glass is a material with many different applications, which makes it difficult for manufacturers or subcontractors to analyze and use. Studying the characteristics of flat glass, hollow glass, fiberglass or clear glass allows companies to better control their composition, their durability and their practical use.As major players in the glass industry you face a variety of challenges relating to the quality of the materials being used, product failures, or even problems with container/contents interactions.Inspections and chemical analysis before and after marketing will contribute to the quality of the finished product.
Our solution : to assess the conformity of a glass or fiber glass sample and to characterize any failures using specific analytical techniques
FILAB, being specialized in analytical chemistry and material characterization assists glass manufacturers in analyzing, inspecting and assessing their products. Organic and inorganic chemistry as well as material science are all areas of expertise are that sought after by the glass industry and brought together in our laboratory guaranteeing responsiveness and high-quality results.FILAB can offer the following services :
ANALYSIS
Custom chemical analysis using ICP-MS and ICP-AES
Surface characterization and coating thickness measurements
Crystallinity analysis
REACH Analysis
Material characterization : physicochemical analysis, thermal and morphological characteristics
Granulometric analysis
Laboratory audit and team training
EXPERTISE
Expert chemical analysis
Deformulation services
Failure analysis : fissures, particulate contamination, adhesive failure, corrosion, metallographic examination, weld analysis
Deposit or pollutant identification
Stability analysis
Laboratory audit and analytical training
R&D
Literature reviews
Research into substitutions for raw materials
Development of new industrial procedures
Creation and transfer of analytical techniques
Creation of new substances
OUR FACILITIES
Organic analysis : GCMS, Py-GCMS, LC-MSMS, GPC, NMR, FTIR
Thermal analysis : TGA, DSC
Powder analysis : XRD, SEM-FEG EDX, BET
Mineral analysis : ICP, XRD, IC
Metallurgical analysis : ICP, SEM-FEG EDX, OES
Surface analysis : SEM-FEG EDX, PES, ToF-SIMS
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Our services
Laboratory analysis of industrial resin
Your resin : to analyze the properties and performances of a resin by studying its composition.
A resin is a polymer used as a precursor in the production of plastics, textiles, paints/varnishes and adhesives. They are used for their thermosetting, mechanical or esthetic propertiesConfronted with a product failure or a change of suppliers, you are looking to characterize the composition and properties of an industrial resin in order to evaluate its performance according to the final use of your product. To achieve this, you wish to carry out chemical analysis with the support of a specialized laboratory.
Our solution : to provide you with our analytical equipment and the expertise of our engineers for the analysis and the optimization of your industrial resins
Thanks to the fact that our facilities complement each other well and our dual expertise in chemistry and materials science, FILAB can perform physicochemical analysis to determine the chemical composition of a resin and polymers in general :Chemical analysis of varnish or resinDetermination of the different compounds making up a resinSurface characterization of a resinPolymer analysisAccelerated aging tests on resinsProduct reverse engineering to determine its compositionDSC curing analysisTGA and TGA-FTIR analysisAnalytical development and validationWith three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Our services
Laboratory analysis and determination of isopropanol contents
Your needs : to determine the isopropyl alcohol (isopropanol) contents in your products in accordance with relevant standards
Isopropanol or isopropyl alcohol is a secondary alcohol and is usually a colorless, volatile and flammable liquid. Isopropyl alcohol is used in industry as a degreasing agent, a disinfectant, a dissolvent or as an additive in gasoline. Isopropanol can therefore be found in numerous products such as paints and varnishes, adhesives, perfumes, makeup removers… Isopropanol is toxic to humans. If ingested, absorbed by the respiratory system or through skin contact, isopropanol can cause irritations, rashes and can even damage the central nervous system.Subject to very many regulations due to its toxicity, isopropanol requires constant monitoring to comply with standards.
Our solution : to provide you with cutting-edge analytical tools for determining the isopropanol contents in your products
As an independent laboratory, FILAB has been assisting industrialists for over 30 years in overcoming their challenges relating to isopropanol. To fulfil your needs, FILAB can provide the following services :
OUR SERVICES
Determination of isopropanol contents using HS-GC-MS or GC-MS
R&D support : deformulation/reverse engineering, literature reviews…
Analytical development and validation of techniques for determining isopropanol contents in your matrices
Sectors of activity
Laboratory analysis of drugs
Your needs : to verify that your drugs comply with relevant standards
As manufacturers producing medication for human or animal consumption (generic drugs, injectable solutions…) you need fulfil many quality requirements surrounding your product. These requirements affect the process of bringing a product to market just as much as the other parts of a medication’s lifecycle. Stringent regulations require you to carry out numerous quality inspections in accordance with the standards stated in the European Pharmacopeia.Non-compliance in medication (presence of impurities, active ingredient/excipient interactions) can cause a product to not receive the necessary authorization to go to market or can cause it to be taken off the market.To overcome these technical challenges, you are looking to cooperate with a reliable and reactive analytical laboratory.
Our solution : to assist drug producers by providing analysis and compliance testing for their products
FILAB offers its high level of technical skill and cutting-edge analytical fleet to pharmaceutical industrialists, providing services meeting their criteria all while abiding by regulatory standards relating to galenic drugs.To precisely and reliably solve overcome these challenges, FILAB offers tailored support with the analysis of your drugs :Chemical analysis of your medications using GC-MS, LC-MS, ICP…Detection of elemental impurities (ICH Q3D) using ICP-MS and ICP-AESParticulate analysis (troubleshooting) using SEM-EDX, FTIR, LC-MS/MS…Reverse engineering of medicationsE&L testingFor more information about our analytical services for your pharmaceutical products (medications, packaging, injectable solution…), feel free to contact us via email at contact@filab.fr, over the phone by calling +33 (0)3 80 52 32 05 or you can request a free quote online here.
Our services
Laboratory analysis and determination of methanol contents
Your needs : to determine the methanol contents in your products to comply with established limits
Methyl alcohol or methanol is a colorless, volatile and flammable liquid. Methanol is used as a solvent (in paints and dyes or to dissolve grease, plastics or mineral salts) as an antifreeze (in coolant) or even as a fuel. Methanol is a raw material used to make plastics or synthetic resins.Methanol, just like ethanol, is toxic to humans. This is why its use and its presence in various products are subject to numerous regulations. Support from a qualified laboratory will allow you to analyze and determine the methanol contents present in your products to comply with relevant standards.
Our solution : to provide you with our analytical facilities to determine the methanol contents of your products in accordance with relevant standards
FILAB laboratory is equipped with a cutting-edge analytical fleet and is made up of a team of qualified experts with extensive experience in handling methanol-based products. To determine the methanol contents of your products, FILAB provides various reliable services :Determination of methanol contents using HS-GC-MS or GC-MSAnalytical development and validation of methods for determining methanol contentsR&D support : deformulation/reverse engineering, literature reviews…Determination of the methanol contents in cosmetic products (perfumes, cremes, gels…)
Our technical resources
Laboratory NMR (Nuclear Magnetic Resonance) Testing
Would you like to carry out a laboratory NMR testing / NMR analysis?
In the FILAB laboratory, we offer NMR (Nuclear Magnetic Resonance Spectroscopy) analysis to provide accurate, in-depth solutions for different industries. This technique allows us to probe the molecular structure and chemical composition of substances, providing information for research, product development, quality control and much more.
The FILAB laboratory provides analytical and expertise services using NMR
Our technical resources: NMR
As part of the development of a new product, a conformity study or following a defect in your product, FILAB offers you a specific NMR analysis service:BRUKER 300 MHzBRUKER 400 MHzBRUKER 500 MHz with CMAS solid probeBRUKER 600 MHz with liquid nitrogen cryoprobe / HRMAS60MH low-field NMR apparatusThe NMRs are also equipped with autosamplers. The nuclei considered are generally the following: H, C, F, Si, P, B, Sn, Se, Pt... FILAB offers these analysis with the support of a partner laboratory.
Our rmn analysis services
Custom NMR chemical analysis of liquids or solids
Interpretations of NMR spectra
NMR molecular characterization
Molecule modification
Development of analytical techniques using NMR
Molecular structural analysis of a sample using NMR
REACH Registration
What is Nuclear Magnetic Resonance (NMR)?
Nuclear Magnetic Resonance (NMR) is an analytical technique used primarily to determine the structure and composition of molecules, by characterising them.NMR is extremely effective for determining the structure of organic and inorganic molecules, and identifying functional groups and the arrangement of atoms in a molecule. Thanks to this analysis, the laboratory can identify the molecular structure, chemical bonds and dynamics of molecules.In addition, NMR is a non-destructive technique, enabling samples to be analysed without altering or destroying them.
What is NMR analysis?
NMR (Nuclear Magnetic Resonance) analysis is an analytical technique used to determine the structure, dynamics, chemical reactivity and molecular environment of molecules. It is based on the magnetic properties of certain atomic nuclei.Nuclear magnetic resonance spectroscopy is used to analyse the characteristics of various materials such as polymers, lubricants, adhesives, surfactants, additives and specifically synthesised molecules.
The principles of NMR analysis
Nuclear Magnetic Resonance (NMR) analysis is based on three fundamental principles: the magnetic field and nuclear spin, radio frequency excitation and the analysis of NMR signals.It is based on the principle that certain atomic nuclei, such as hydrogen and carbon, have magnetic properties. When placed in a strong magnetic field and exposed to specific radiofrequency waves, these nuclei absorb and emit energy at characteristic frequencies, enabling them to be identified. NMR is therefore based on the detection and analysis of the signals emitted by these nuclei.
Why carry out an NMR analysis in the laboratory?
Carrying out NMR (Nuclear Magnetic Resonance) analysis in the laboratory has many advantages, making this technique essential in various fields of research and industry:Purity and composition analysis: this is used to analyse the purity of compounds and detect impurities, even in very low concentrations, as part of chemical analysis and product quality control. Pharmaceutical development: in the pharmaceutical industry, NMR is essential for the design and validation of drugs, enabling the structure and conformity of active ingredients to be analysed. Polymers and materials: it is also used to characterize materials such as polymers, by determining their chemical composition and physical properties.In short, NMR is a versatile and powerful technique, indispensable in many sectors for its ability to provide complete and accurate information on the chemical structure and properties of molecules.
Our complementary analysis services
FILAB laboratory also offers analytical services complementary to NMR analysis, strengthening the value of the analysis :Determination of absolute molecular weight using GC/SECGC-MS analysisLiquid chromatography analysis coupled to a mass spectrometer (LC-MS)Matrix-assisted desorption/ionization mass spectrometer (MALDI-MS)Analytical development and validation for measuring the molecular weight of your samples
FAQ
What is nuclear magnetic resonance (NMR) and what is it used for?
Nuclear magnetic resonance (NMR) is an analytical technique used to determine the chemical structure of molecules by observing the interactions of atomic nuclei with a magnetic field. This method is essential for identifying compounds, assessing the purity of a sample and understanding its molecular properties.
How do you interpret an NMR spectrum?
An NMR spectrum provides information about the different chemical environments of nuclei in a sample. Analysis of a 1st order NMR spectrum allows molecular structure to be deduced by examining parameters such as NMR chemical shift and coupling constants.
What is chemical shift in NMR?
NMR chemical shift measures the change in resonance frequency of a nucleus relative to a standard reference. It reflects the electronic environment of the nucleus and helps to identify the different atoms within a molecule. It is a key element in the analysis of an NMR spectrum.
What is the difference between NMR spectroscopy and nuclear magnetic resonance (NMR)?
NMR spectroscopy is the experimental technique used to obtain NMR spectra. The term ‘nuclear magnetic resonance (NMR)’ refers to the underlying physical phenomenon, while NMR spectroscopy refers to the use of this technique to analyse samples.
What types of samples can be analysed by NMR in the FILAB laboratory?
The Filab laboratory offers NMR analysis for a wide range of samples, including organic compounds, polymers and pharmaceuticals. Using NMR spectroscopy, we can identify molecular structures and assess the purity of submitted samples.
How does the Filab laboratory use NMR spectroscopy in its analysis?
In the Filab laboratory, we use NMR spectroscopy to analyse samples, focusing on the interpretation of NMR spectra, the study of chemical shifts and spin-spin couplings. These analyses provide accurate results on the composition and molecular structure of samples.
Our services
Laboratory analysis of PEEK polymers
Your needs : to verify that the performances of your PEEK polymers comply with relevant standards using cutting edge techniques
The use of plastics has become increasingly widespread in industrial fields. Among them, polyether ether ketones (or PEEKs) are high performance materials, chosen for their thermal stability and chemical resistance.PEEKs are used in many industrial applications such as aeronautics, medical devices, energy production...
Our solution : to provide reliable and responsive analysis services as part of the inspection of PEEK materials
With extensive experience in material analysis and characterization, FILAB laboratory can assist you in understanding the behavior of your PEEK substances and in finding appropriate solutions in the event of a failure.Thanks to an analytical fleet spread over 5 200m², FILAB laboratory offers several analytical services for PEEK substances :- Determination of the nature of polymers using GC-MS, FTIR, TGA or DSC- Deformulation/Reverse engineering of polymers- Determination of additives in PEEK products- Failure analysis of PEEK products- Conformity inspection as part of REACH analysis- Thermal and thermogravimetric analysis- Development of analysis procedures.- Identification of chemical composition
Our services
Nitrosamines: analysis laboratory for the pharmaceutical industry
At the request of the EMA (European Medicines Agency), Marketing Authorization Holders (MAH) are required to monitor the presence of nitrosamines in their medicines, by presenting, among other things, an assessment of the potential contamination risks. This evaluation must be done before March 26th 2020 in France and before May 15th 2020 in Switzerland.
Nitrosamines classified as “dangerous” found in certain medicines
Chemical reactions between amines, ammonia salts and nitrites, cross contaminations, the use of contaminated ingredients, packaging, cleaning protocols… potential sources of nitrosamines are numerous and widespread.Classified as, or suspected to be carcinogens, European and American markets have more than once had to carry out mass recalls of medicines designed for human consumption containing trace amounts of nitrosaminesIn 2018, the EMA lead investigations and information campaigns with the support of competent authorities to reduce the risk of nitrosamines being present in pharmaceutical products. In September of 2019, the EMA and the CMD published a document titled “Information on nitrosamines for marketing authorization holders” detailing the importance of evaluating the risk of nitrosamine contaminations during production processes.New requirements are also added to the responsibilities of MAHs for the inspection of impurities as well as of active ingredients and some other components (dyes, solvents, catalysts…).
Steps to follow :
In this regard, measures must be implemented quickly, following these steps :Step 1 : Risk assessment and management in accordance with ICH Q9 guidelinesClassification of APIs and medicines by priority (daily dose, treatment duration, route of administration, patient profile…)Determination of the risk of potential nitrosamine contaminations depending on the production processDetailed conclusions on the presence of absence of a riskThe EMA has asked for a report on these evaluations before March 26th 2020SWISSMEDIC set their deadline to May 15th 2020.Step 2 : Confirmation testsIf a potential risk has been identified, analysis must be carried out in the order set in the first step, sorting by priority and in accordance with the following requirements :The analytical methods must be validatedLoQ must be under 30 ppbThe analysis being carried out must comply with GMPAuthorities will have to be informed if the results reveal that nitrosamines are present, whatever the amount may be.Step 3 : Implementation of corrective procedures Corrective procedures (a change in the production process, a change in the supplier’s scope statement…) will need to be implemented before September 26 2022, 3 years after the EMA published their document and November 15th 2021, 2 years after SWISSMEDIC published theirs.
FILAB : providing specific services for evaluating the risks of nitrosamine contamination
The FILAB laboratory has developed precise and optimised analysis methods to detect and measure the following nitrosamines, among others, using the LC-MSMS technique:The limits of detection for determining nitrosamine contents vary from 1 to 10 µk/kg depending on the nitrosamine and matrix being used.It is important to note that FILAB uses many methods which have been validated by COFRAC, a member of ILAC, for determining nitrosamine contents using LC-MS/MS. NDMA (CAS : 62-75-9)NDEA (CAS : 55-18-5)NEIPA (CAS : 16339-04-1)NDIPA (CAS : 601-77-4)NMBA (CAS : 61445-55-4)NDBA (CAS : 924-16-3)NMPA (CAS : 614-00-6)NDPA (CAS: 621-64-7)FILAB also provides other services that can fulfil your needs relating to nitrosamines :Development, validation and transfer of methods for determining nitrosamine contentsDeformulation/Reverse engineering (additives, adjuvants…)REACH analysisCompatibility and stability testingNanomaterial characterizationTroubleshootingElemental impurity analysis (ICH Q3D)
Our services
Thermal analysis on polymers
How to better monitor and analyze the thermal characteristics of your polymers?
Thermal analysis of a polymer makes it possible to characterize its behavior when subjected to thermal constraints (high heat).This step is used to be able to anticipate the performance or potential degradation of a polymer in specific thermal conditions throughout its lifecycle (from creation to its final use).
How can FILAB assist you with your need to carry out thermal analysis on your polymers?
For over 30 years, FILAB laboratory has had the experience and specific analytical fleet needed to be able to fulfil requests for thermal analysis for many industrial clients. Polymers and composites alike, FILAB is able to support companies in characterizing their materials through reliable and personalized thermal analysis and by helping interpret their results.FILAB uses various thermal analysis techniques, making it possible to highlight the physicochemical specificities of a polymer depending on outside temperature:Pyrolysis analysis paired with GC-MS (Py-GC-MS)Thermogravimetric analysis (TGA, TGA paired with FTIR)Differential Scanning Calorimetry (DSC)Gas Chromatography (GC-MS)Thermal Desorption analysis (Thermal Desorption Unit paired with Gas Chromatography TDU-GC-MS)Differential Thermal Analysis (DTA)
And to go even further?
Going past thermal analysis, FILAB is able to fulfil a wide range of requests regarding polymers, such as :- Reverse engineering- Quality control- Failure characterization- Stability testing- And more…
Our services
Laboratory analysis of toxic trace residue
Your needs: to characterize any unknown trace residue found in your products and to ensure they comply with standards
Following the discovery of a non-compliant product or as part of a procedural improvement, industrialists can be required to carried out elemental analysis looking for trace residue in organic or inorganic matrices. Even in trace amounts, certain elements such as heavy metals (Lead, Mercury, Cadmium…) can pose a considerable health risk to consumers. Being subject to very stringent regulatory constraints, it is crucial to monitor their presence in all kinds of products.Inspections looking for trace residue require precise tools, needing to be able to detect concentrations down to the ppm or even ppb range. Support from a specialized laboratory is will therefore allow you to quickly and precisely analyze your samples.
Our solution: to provide you with quick and reliable trace analysis services for any kind of matrix
As an independent laboratory situated in Dijon, France, FILAB have been active for 30 years supporting industrialists from all fields by providing trace element analysis and characterization services. Equipped with a diverse and cutting-edge analytical fleet (ICP, GC-MS, IC, SEM EDX…) FILAB can adapt its methods to fit any kind of matrix needing to be studied (Liquids, Solids, Powders…).These are some of the services we are able to provide:
Our services
SEM-EDX trace element characterization on surfaces
Elemental analysis
Analysis of metallic impurities in pharmaceutical products (ICH Q3D)
Reverse engineering of finished products
Analysis and determination of heavy metal content using ICP-MS and ICP-AES in chemical matrices (Lead, Mercure, Cadmium, Chromium…)
Detection of elemental impurities (contaminations, pollutions, residue…)
Development of custom analytical methods
Ensuring a quick turnaround for your requests, FILAB is able to assist industrialists with regular or one-off inspections looking for trace residue. FILAB is also ISO accredited for many of these analysis for the pharmaceutical and cosmetics industries and for environmental analysis.
Our services
Deformulation, study of the chemical composition of formulas or materials
What is reverse engineering?
The deformulation or "reverse engineering" of a commercial product, often made up of a complex mixture, consists of determining, through various chemical analyses, the nature and quantities of raw materials present in the formulation.This application can be applied to different types of products, formulas and materials: paints, plastics (polymers), composites, metals and metal alloys, varnishes, etc.
In what context do industries need to check the chemical composition of products or materials?
Analyse and determine the composition of an unknown mixture
Check compliance with a Safety Data Sheet (SDS) or technical data sheet
Comparing the composition of several products (double-sourcing or multi-sourcing)
Analysis of competing products
Analyse and identify pollution or impurities
The success of deformulation depends on a good understanding of the target application and the use of rigorous analysis methods to characterise the chemical composition of the organic and mineral fractions.
Deformulation
Our services
We can carry out deformulation in a very large number of cases:
Materials
The deformation of materials makes it possible to determine their composition, facilitating the improvement of existing materials and the development of new products. This analysis is essential in industries such as aerospace and automotive, where precise knowledge of materials contributes to performance and safety.
Glue
Adhesive deformation helps to understand the chemical composition and adhesion properties of adhesives used in various industrial applications. This analysis is common for sectors such as construction and electronics, where optimal adhesion is required to ensure the durability and reliability of assemblies.
Mix
Mixture deformation involves the analysis of complex formulations to identify and quantify components. This technique is particularly useful in industries where compliance with safety standards and product innovation are priorities.
Polymers
Polymer deformation enables polymer materials to be analysed to reveal their structure and additives. This knowledge is essential in the plastics industry to develop products that are stronger, lighter and more environmentally friendly.
Varnish
By deforming varnishes, laboratories can discover the resins, plasticisers and other components used. This type of analysis supports industries by ensuring the quality and durability, in particular, of surface finishes.
Composite
The deformation of composite materials helps to identify the matrices and reinforcements used, which is essential for sectors requiring high-performance materials, but also when lightness and strength are key characteristics.
Competing product
This type of reverse-engineering analysis enables companies to understand the formulations of competing products, providing an opportunity to optimise their own products or develop competitive alternatives. It is particularly valued in highly competitive sectors such as cosmetics and chemicals.
Active substance
The deformulation of active ingredients is essential for the pharmaceutical industry in particular, enabling the composition and mechanism of action of active substances to be understood. This analysis contributes to your innovation process and ensures regulatory compliance.
Pharmaceutical product
The analysis of pharmaceutical products through deformation helps to identify excipients and active agents, essential for guaranteeing the efficacy and safety of medicines, thus meeting strict regulatory requirements.
Elastomer
The deformation of elastomers details the composition and properties of these flexible materials, used by industries where durability and adaptability are essential, such as automotive and seal manufacturing. This analysis enables formulations to be refined to improve characteristics such as elasticity and resistance to extreme environmental conditions.
Silicone
Silicone deformation helps to identify the specific components and formulations of these versatile materials, which are essential for sectors requiring high performance and biocompatibility, such as medical and electronics. This analysis helps to optimise properties such as thermal resistance and flexibility, which are crucial to the development of safe, durable products. It also supports innovation and continuous improvement in silicone applications.
Rubber
The deformation of rubber reveals the components and additives used in its manufacture, offering valuable insights into improving the quality and performance of rubber products. This analysis is particularly important for the automotive industry, where high quality tyres are essential for safety and durability.
Our technical resources
Gas chromatography
(GCMS, HS-GC/MS, GC-FID, Py-GC/MS)
Infrared microscopy (IRTF)
Nuclear Magnetic Resonance (NMR)
Liquid Chromatography
LCMS, LC-UV, LC-QTOF, LC-CAD...
Scanning Electron Microscopy (SEM)
RAMAN Spectrometry
Karl Fischer
Discover our case study
How did FILAB help one of its customers understand the yellowing of a silicone?
Find out more
Our technical resources
Laboratory determination of water contents by Karl Fischer titration
You are looking to measure the water content of a sample using the Karl Fischer method…
Karl Fischer titration is a method for determining water content in a sample. It is particularly well adapted to measure the water content of a liquid or to detect trace amounts of water, down in the ppm range, in other types of samples. The whole procedure is based on the oxidation of sulfur dioxide by diiodine.Measuring water content by Karl Fischer titration can be done with different types of samples : pharmaceutical, chemical, petroleum-based, plastic…
Our solution : to provide you with our analytical equipment designed to measure water content by Karl Fischer titration
As part of an R&D project, FILAB is able to assist industrialists from various fields in measuring the water content of their product by Karl Fischer titration.Complementary to this type of analysis, FILAB is able to study the overall characteristics of your products by providing the following services :
Our services
Chemical analysis using GC-MS, LC-MS/MS, NMR, ICP-MS…
Raw material inspections
Reverse engineering services
Determination of heavy metal content
E&L testing
Development and transfer of analytical methods
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Our services
Literature review services
Your needs: to conduct a swift and complete literature review as part of an R&D project or an investigation
What does a literature review entail?
A literature review consists of assembling any available technical and scientific information such as articles, patents, work projects etc. which may be useful in understanding a current problem or industrial challenge. Reviews can also be conducted as part of research and development projects (R&D) in any industrial field.
Why carry out a literature review?
The literature review will provide an overview of the current state of the art in the field, leading to the development of a number of working hypotheses that can then be verified through laboratory experiments (formulation, performance tests, chemical analysis and characterization of materials, etc.).
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.A genuine tool for innovation, the literature review can be useful for :
integrating new markets
material substitution
understanding non-conformities (changes in product colour, odour problems, etc.)
the development of new materials
optimisation of production processes
With this in mind, the support of a specialised laboratory enables you to centralise research and application testing in a single location, making your R&D projects more efficient, responsive and reliable.
Our solution: to provide you with complete literature reviews with specific technical and scientific assistance
Why call on FILAB for a literature review?
With dual expertise in chemistry and materials science, and a team made up of experienced doctors and engineers, FILAB is able to conduct literature reviews to assist industrialists with their R&D projects.Are you short on time? On internal means for conducting a literature review?FILAB can provide you with the necessary expertise and support to carry out literature reviews and provides assistance at every step of the way:
Drafting of a scope statement
Formation of a hypothesis
Tests in real world conditions
Patent registration
Study of what already exists
Research proposal to test the hypothesis
Industrialization phase
Our R&D support goes beyond literature reviews
Product development or optimisation
Selecting materials with Granta Selector
Advice on the choice of materials (dual sourcing assessment)
Specific characterization tests
Deformulation (Reverse engineering) of materials
Laboratory tests
With three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Our services
Material Testing & Chemical Analysis Services for Industry
Advanced Material Testing Solutions for industrial applications
Filab is a leading independent chemical analysis and material testing laboratory based in France, dedicated to serving industrial clients (B2B). Whether you're developing a new product, validating material specifications, or facing a production challenge, Filab provides high-level expertise in materials characterization, chemical composition analysis, and compliance testing.We offer a complete range of industrial material testing services, tailored to meet the strictest quality and regulatory standards.Our ISO 17025-accredited laboratory works with clients in the pharmaceutical, automotive, aerospace, cosmetics, energy, metallurgy, and construction sectors.
Our material testing and chemical analysis services
We offer a broad spectrum of material testing solutions and chemical characterization services. Here are our main areas of expertise:
Chemical Composition Analysis
Determine the exact elemental or molecular composition of your raw materials, semi-finished goods, or end products. Techniques include:
ICP-MS / ICP-OES
CHONS elemental analysis
Thermogravimetric Analysis (TGA)
Whether you need to check metal content, detect impurities, or confirm compliance with REACH or RoHS, Filab is your trusted partner.
Material Characterization
Understand how the structure and properties of a material relate to its performance in real-world conditions.
XRD (X-ray Diffraction) for crystal structure
SEM/EDX (Scanning Electron Microscopy)
FTIR and Raman Spectroscopy
DSC (Differential Scanning Calorimetry)
Porosity and surface area measurement (BET)
Our material characterization experts help you select the right materials, validate surface treatments, or troubleshoot unexpected behavior in use.
Industrial quality control testing
We support manufacturing facilities with routine batch testing, raw material verification, and finished product validation.
Compliance with ISO, ASTM, or client-specific standards
Surface cleanliness testing
pH, viscosity, and density checks
Failure analysis & troubleshooting
When components fail or defects occur, our lab performs root-cause investigations using analytical and structural techniques:
Microstructure examination
Corrosion or contamination studies
Phase analysis via XRD
Coating integrity checks
Know more about our material testing services
If you’re searching for a material testing laboratory, chemical analysis services, or a partner for industrial material inspection, Filab is your solution.
We can help you with:
Advanced materials analysis
Material characterization testing
Industrial material testing services
Chemical testing for industry
Failure analysis and root cause studies
Structural and surface analysis
Analytical testing of substances
Quality control testing in manufacturing
Raw material inspection services
What analysis techniques are used to characterise materials?
The FILAB laboratory's analytical facilities cover 5,200m² and offer a range of techniques to best meet your materials characterisation needs. In addition, the laboratory invests heavily each year in its analytical facilities in order to maintain its high-performance technical resources.
Our techniques
Analysis of the organic fraction
IRTF, GC-MS, HPLC
Surface analysis
MEB, EBSD, AFM, TOF-SIMS, XPS
Mineral fraction analysis
ICP, SEO, DRX, Elemental analysers
Thermal analysis
ATG, Py-GCMS, DSC
Other
BET, Optical Microscope, Helium Pycnometry, GPC, DMA/TMA, Goniometer, Granulo Laser, IGA, RAMAN...
Why choose Filab for your material testing needs?
As a B2B chemical analysis partner, we understand the challenges industries face: tight deadlines, stringent norms, and high-performance expectations. That’s why we offer:
Certified Expertise
Our laboratory is ISO 17025 accredited and complies with GLP/GMP when required. Our chemists, engineers, and PhD scientists provide in-depth analysis using state-of-the-art instrumentation.
Customized Testing Protocols
We don’t believe in one-size-fits-all. Every material assessment or chemical testing request is tailored to your needs—whether for R&D, quality control, or failure investigation.
Speed and Responsiveness
We deliver fast turnaround times without compromising reliability. Our technical team is always available to discuss results, regulatory requirements, or emergency testing.
We collaborate with your technical team to understand the problem, identify causes, and recommend corrective actions.
our clients
Filab supports clients across Europe in sectors such as:
Pharmaceutical and Biopharmaceutical
Medical Devices
Automotive & Aerospace
Energy and Batteries
Metallurgy and Foundry
Packaging and Plastics
Cosmetics
Whether you're a multinational or an SME, we provide the same level of precision, confidentiality, and customer care.
Complementary services
Looking for more than just standard material testing?We also offer:
Reverse engineering: Deconstruct materials to understand composition and structure.
Long-term aging & stability testing: Simulate real-world usage.
Benchmarking studies: Compare your materials to market standards
Contamination analysis: Identify trace residues or foreign particles
Our FAQs
What is the purpose of material testing?
Material testing is used to assess the physical, chemical, or structural properties of materials to ensure they meet performance and regulatory requirements. It helps companies choose the right material, validate manufacturing processes, and guarantee product safety and reliability.
What’s the difference between material testing and chemical analysis?
Material testing refers to evaluating the behavior or integrity of a material (e.g., strength, structure, durability), while chemical analysis focuses on its composition—what elements or molecules it contains. At Filab, we offer both as complementary services.
How can I choose the right laboratory for material testing?
Look for a lab that is ISO 17025 accredited, experienced in your industry, and able to offer tailor-made support. Filab combines scientific rigor with responsive service, making us a reliable partner for complex industrial needs.
What is raw material analysis and why is it important?
Raw material analysis involves verifying the quality, purity, and compliance of incoming materials before they are used in production. This ensures consistency, reduces the risk of defects, and helps meet regulatory standards. Filab offers tailored raw materi
Does Filab offer urgent testing?
Yes, we offer fast-track services for time-sensitive projects. Contact our team to learn more about lead times and express options.
What type of materials can be tested?
We work with metals, polymers, ceramics, composites, liquids, powders, coatings, and more. If you're unsure whether your sample qualifies, just ask—we’ll guide you through the process.
Do you help with product development?
Absolutely. We collaborate with R&D teams on formulation validation, material selection, and competitive analysis to accelerate product development and market readiness.
What tools are used to characterise materials?
Some of the most commonly used tools for materials characterisation include:microscopy (optical, electron, confocal, atomic force),spectroscopy (infrared, Raman, and other types of optical and radiation spectroscopy),X-ray diffraction,calorimetry, rheology (dsc analysis),thermogravimetric analysis,and mass spectrometry.
Sectors of activity
Laboratory analysis and testing for the defense and security sector
Your needs : to design efficient, innovative and reliable materials with regard to security
As major players in the arms industry, as manufacturers of security devices, as producers of electronic components for high tech equipment, as experts in the production of nanomaterials, you are searching for a way to improve in the field of safe, reliable micro technology.Inspection of raw materialsSurface functionalizationIntegrating multiple functions into the same chipUnderstanding defects and anomaliesMiniaturizing your productsTo assist you with these various technological challenges, cooperation with a reliable, reactive laboratory with high added technical value guarantees that your products will conform to regulations and will assist you in your innovative efforts.
Our solution : to assist industrialists from the defense sector in analyzing and characterizing materials and in the development of new procedures.
As an independent laboratory situated in Dijon and housing a 2100m² analytical fleet, FILAB has a lot of experience in providing assistance as part of projects for the defense and security systems industry. FILAB offers its analytical services, its expertise and R&D advice for the following activities :
ANALYSIS
Chemical analysis : VOC, residual solvents, heavy metals, additives...
Surface analysis : welding, surface treatment, coating thickness measurements…
Microsection characterization
REACH analysis
Material characterization : metallic alloys, polymers, composite materials, glass, ceramics…
Thermal analysis and characterization
Granulometric analysis
EXPERTISE
Expertise in analytical chemistry
Deformulation services
Failure analysis : studying fissures, adhesive problems, corrosion, metallographic examination, weld analysis…
Using SEM-EDX and FTIR to identify pollutants and deposits
Compatibility studies
Laboratory audit and team training
R&D support
Creation, validation and transfer of analytical techniques
Searching for product substitutions
Literature reviews
Developing a new formula or a new product
our resources
Organic analysis : GCMS, Py-GCMS, LC-MSMS, GPC, NMR, FTIR
Thermal analysis : TGA, DSC
Powder analysis : XRD, SEM-FEG EDX, BET
Mineral analysis : ICP, XRD, IC
Metallurgic analysis : ICP, SEM-FEG EDX, OES
Surface analysis : SEM-FEG EDX, PES, ToF-SIMS
Our services
REACH testing in a laboratory
Your needs: analyse your chemical substances reliably and comprehensively to prepare your REACH dossiers
What is REACH?
REACH is the European regulation that requires all manufacturers and importers of chemical substances, including mixtures of more than one tonne per year, to register these substances with ECHA (the European Chemicals Agency, based in Helsinki).The main aim of the European REACH (Registration Evaluation and Authorisation of Chemicals) regulation, which came into force on 1 June 2007, is to improve knowledge of the many chemical substances in circulation. Manufacturers, users and importers of these substances located in the EU must undergo the REACH test.
Sharing information under REACH
The REACH analysis requires manufacturers to identify and assess the risks associated with the production, use and disposal of chemical substances. They must also communicate this information to ECHA (the European Chemicals Agency) and to their customers in the supply chain. Compliance with REACH ensures that chemical substances are used safely throughout their life cycle, from production to disposal.
Which substances are concerned?
All substances are covered, including natural substances, organic substances and metals, as well as those used in industrial processes and those found in mixtures or objects. Here are the main categories of substances covered by the REACH analysis for use in the European Union:Chemical substances used alone or in mixtures in various industrial processes or consumer products, such as paints, inks, and detergents, or textiles.Finished products: objects that contain chemical substances as an integral part of their structure (clothing, furniture, electronic equipment) are concerned. If these articles release chemical substances under certain conditions, these substances must be registered.Substances of very high concern (SVHC), including toxicity, carcinogenicity, CMR, PBT and vPvB substances, because of their danger to human health or the environment.Substances subject to authorisation or restriction because of their hazardous properties, or requiring specific authorisation for certain uses, or subject to a marketing ban.New chemicals: Any new chemical substance placed on the EU market must be registered before it is marketed.
Why carry out a REACH laboratory analysis?
REACH analysis is essential for manufacturers not only to comply with legal requirements, but also to protect human health, preserve the environment, manage risks effectively, encourage innovation and maintain access to the European market. The information collected relates in particular to the physico-chemical properties and toxicological assessment of substances. To obtain and validate this data, a REACH test must be carried out.This is why it is essential for manufacturers to carry out a REACH analysis:
Legal compliance: the REACH regulation requires companies that manufacture, import or use chemical substances in the EU to ensure that these substances do not harm human health or the environment.
Access to the European market: for a company to be able to sell its products containing chemical substances on the European market, it must demonstrate its compliance with REACH.
Risk management: REACH analysis helps manufacturers to identify, assess and manage the risks associated with the use of chemical substances in their production processes and throughout the supply chain.
Environmental responsibility: by assessing the environmental impact of chemical substances, manufacturers can take steps to reduce harmful emissions, improve waste management and promote more sustainable production.
Innovation: the REACH analysis encourages industries to research and develop safer alternatives to hazardous substances. This can lead to innovation in products and production processes, offering a competitive advantage.
The FILAB laboratory can help you with the REACH analysis of your substances
For over 30 years, our FILAB laboratory has had the experience and specific analytical equipment to support companies in the analysis of their substances and new materials, through tailor-made assistance.From REACH analysis to R&D, the FILAB laboratory offers multi-sector expertise to meet a wide range of REACH analysis requirements.
Our REACH analysis services
Analysis of the chemical composition of a substance as part of a REACH dossier
Deformulation of substances
Determination of chloroalkanes (SCCP) in accordance with REACH
Analysis and dosage of halogens including bromine
Identification of REACH substances
Pigment analysis according to REACH
REACH analysis in cosmetics
Lead analysis
Sameness analysis between two substances
Characterization of nanomaterials under REACH
Characterization of polymers under REACH
Method development in accordance with REACH
Purity control according to REACH
REACH analysis of UVCB substances
REACH analysis for the chemical industry
Our technical resources for REACH analysis
NMR
GC
HPLC
ICP OES
XRD
XRF
Did you know ?
FILAB assists its customers with the development of new chemical formulas, for example CMR substances. For many years now, FILAB has been asked to identify formulas, products or materials that might contain CMR chemical substances according to the REACH definition.We provide our industrial customers with our R&D skills and experience to enable them to incorporate more effective, environmentally-friendly and safer formulas into their industrial processes.
FAQ
Why is REACH analysis important?
The REACH analysis is important because it is designed to protect human beings and the environment from the risks associated with chemical substances. It makes it possible to:Identify chemical substances that may cause health problems or have an impact on the environment, and regulate their safe use.Companies to demonstrate the safety of their products: Manufacturers, importers and distributors must provide information on chemical substances to their customers, to ensure the safe treatment, handling and use of these products throughout the supply chain.Consumers must have a better understanding of chemical products. REACH analyses oblige companies to provide information on the chemical substances present in their products, enabling consumers to be better informed about potential risks and to make more informed choices.
Who is affected by REACH analysis?
REACH applies to all companies that produce or import chemicals in quantities exceeding one tonne per year. They must register with the European Chemicals Agency (ECHA). Companies that use chemicals in the course of their business (e.g. chemical manufacturers, production companies, downstream users) must also take measures to ensure the safe use of these chemicals, by complying with the provisions of REACH.
Our services
REACH substance identification in a laboratory
Your needs : to characterize the chemical composition of your substances as part of the REACH registration process
REMINDER : REACH is a European regulation which requires that producers or importers of chemical substances, including mixtures register their substances with the ECHA (European CHemical Agency) if they produce/import more than one metric ton of said substances per year.
As part of this regulation, industrialists need to inspect and precisely characterize their substances to ensure that they comply with standards in order to be registered.
Any given substance must have a chemical name, a number and in the case of mixtures, their composition must be given (components + amounts). The quality of the data provided will influence the time it takes to add the substance to either the authorization or restriction list.
Before filling a REACH registration request, you are looking to cooperate with an analytical laboratory to identify and name your substances…
Our solution : to provide you with our reliable, diverse and precise analytical techniques making it possible to quickly identify the chemical nature of a substance or of a mixture
Relying on a cutting edge-analytical fleet spread over 5 200m² and a team of experts in chemistry and materials science, FILAB laboratory is able to assist you in obtaining REACH registration by providing analysis and identification services for all kinds of substances :
Custom chemical analysis for identifying substances (heavy metals, residual solvents, additives…)
Purity testing
Determination of elemental contents
Raw material inspection
Chemical reverse engineering
Development of analytical methods
Material characterization
Development of Substance Identification Profiles (SIP)
To carry out these tests on all kinds of matrices, FILAB uses a diverse set of analytical techniques :
NMR : 1H, 13C, 17O, 31P…
GC-FID, GC-MS, HS-GC-MS (Gas Chromatography)
HPLC-MS/MS, HPLC-DAD (Liquid Chromatography)
IC (Ion Chromatography)
ICP-AES, ICP-MS
FTIR (Infrared Spectroscopy)
UV-Vis
DSC
XRD
TGA
SEM-EDX (Scanning Electron Microscopy)
If you wish to know more about our substance identification services, feel free to contact us !
What is the REACH regulation?
REACH is a European regulation which came into effect in 2007 to secure the manufacture and use of chemical substances in the pharmaceutical industry. In order to comply with the regulations set by the REACH registration process, substance identification is a crucial step.
Indeed, the registration process relies heavily on REACH analysis, and therefore on substance identification offered by a REACH laboratory.
What is the purpose of substance identification in a REACH laboratory ?
A substance identification lab handles a procedure involving detailed chemical analysis, which enables the identification of the exact composition of a substance. It is required to accurately characterize each component and provide reliable data on their hazards.
The chemical industry is well-versed in the importance of calling a substance identification lab as it ensures the safe handling and use of chemicals by all users and helps establish an appropriate risk management strategy.
What services does a REACH analysis laboratory offer?
A REACH laboratory provides a range of services to support companies in their REACH registration process. FILAB is capable of planning this test, in accordance with REACH chemical testing requirements.These services include testing, advice, and support to help companies comply with the complex and ever-changing REACH regulations.
A REACH analysis laboratory conducts tests to determine the chemical composition and potential hazards of products, and advises on the appropriate use of chemicals in line with REACH regulations. They also offer support in preparing and submitting REACH dossiers, and ensuring compliance with the latest updates and changes in the REACH registration process.
What is the regulation for REACH nanomaterials?
The use of nanomaterials is rapidly growing, offering numerous innovative applications, especially in the industrial sector. There are a large number of products with nanomaterials available on the European market, such as coatings, batteries, cosmetics, food products, antibacterial clothing, or textiles.
The regulation of REACH nanomaterials is an essential component of the REACH registration
process. It is a comprehensive framework that covers all aspects of nanomaterials as the properties, uses, and their potential impact on human health and the environment. The regulation requires companies to identify the nanomaterials in their products and register them with the European Chemicals Agency (ECHA).
Our services
Surface analysis and characterization laboratory
FILAB, laboratoire d’expertise de surface depuis plus de 30 ans, accompagne les industriels pour fiabiliser leurs matériaux, résoudre les défaillances et optimiser leurs procédés.
Your needs: surface characterisation of your materials
Knowing the properties and surface conditions of a material can help you adapt your manufacturing processes. With the support of a specialist laboratory, you can carry out analyses and expert reports on the surface of materials to optimise your performance.The surface of a material is a vulnerable zone where numerous interactions with its environment take place. Its specific characteristics determine the overall performance of materials. It can have an impact on the reliability and strength of a product in the event of failures (corrosion, wear, adhesion, friction, etc.).
Why use a materials surface expertise laboratory?
Laboratory surface expertise enables us to understand properties such as roughness, surface energy, chemical composition and the presence of contamination or treatments.This information is essential for optimising the adhesion, resistance, functionalisation and cleanliness of surfaces in many industrial sectors.
Nuclear
Aerospace
Spatial
Medical
Electronics
Defence/Security
Automotive
Our bespoke surface analysis services and techniques
Analysis
Our surface analysis services
Analysis of the chemical composition of the surface
Surface chemistry is concerned with the surface properties of materials. It enables the chemical properties of surface materials to be modified, if necessary, to give them new properties suited to their use.
Morphological and topographical study
Morphology, the three-dimensional study of surfaces, and topography, analysed at macro, micro and nanometric levels, are crucial for optimising industrial manufacturing processes. These analyses help to prevent failures by providing an in-depth understanding of material properties.
Mesure d’épaisseur des couches de surface
Multilayer analysis of material surfaces involves examining several surface layers of a material. This technique is widely used to identify the surface composition of materials.
Controlling surface cleanliness
The surface of a material interacts with its external environment and may encounter chemical contamination or particle pollution as a result of the various stages in the manufacturing process, for example.
Surface tension measurement
The measurement of surface tension determines the force acting on the surface of a liquid, due to the attraction between its molecules. This force is responsible for behaviours such as droplet formation and spreading on surfaces, and enables the surface area of the liquid to be minimised. This measurement is used to understand and optimise liquid-liquid and liquid-solid interactions in various industrial and scientific contexts.
Surface topography analysis
Surface topography analysis is used to optimise the contact, adhesion and durability properties of materials, particularly for coatings, medical devices and aeronautical components. During this surface analysis, the physical characteristics of a material's surface, such as its texture, asperities and overall shape, are assessed.
Analysis VSSA
VSSA analysis is used to determine the specific surface area of a material per unit volume. This analysis is mainly used in the pharmaceutical industry and for characterising materials, particularly porous materials or powders, where chemical reactivity and dissolution are influenced by the specific surface area.
Surface tension measurement
The measurement of surface tension determines the force acting on the surface of a liquid, due to the attraction between its molecules. This force is responsible for behaviours such as droplet formation and spreading on surfaces, and enables the surface area of the liquid to be minimised. This measurement is used to understand and optimise liquid-liquid and liquid-solid interactions in various industrial and scientific contexts.
Profilometry analysis
Profilometry focuses primarily on the quantitative measurement of vertical variations in the surface of a material. This surface analysis provides precise information on surface texture, guaranteeing product quality and performance.
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Expertise
Our surface expertise services
Nano-scale surface expertise (extreme surface analysis)
FILAB is able to analyse the surface of a material on a nanometric scale(extreme surface analysis or surface expertise) using cutting-edge techniques such as TOF-SIMS, XPS/ESCA and AFM.
Identification of surface pollution
As well as checking the surface cleanliness of the material, the laboratory identifies the pollution in question.
Interface analysis
Materials interface analysis is a technique for studying the transition zone between two distinct substances in a composite material. It enables us to understand the chemical and physical interactions at the interfaces, which are crucial to the material's performance and stability.
Failure study - characterisation of a surface defect
Corrosion, cracks, fractures, adhesion problemsBy analysing the imperfections in your metal alloys, we can determine their origins and impact. We carry out detailed analyses of failures to provide an in-depth understanding of their nature and scope.
Checking the homogeneity of surface treatments
Checking the homogeneity of surface treatments is essential to ensure the uniform quality and performance of materials, making it possible to detect and correct any variations or defects in the treatment process. This verification guarantees the reliability and durability of materials in their specific applications.
Adhesion analysis
Adhesion analysis is used to assess the strength with which two surfaces bond to each other, for example between a coating and a surface. Knowledge of this characteristic guarantees the reliability and durability of coatings and assemblies in the automotive, aerospace and electronics sectors, for example.
Traitement par grenaillage
Shot peening is a surface treatment process in which small beads are impacted onto a material to improve its texture or mechanical properties. This laboratory process improves the fatigue, corrosion and wear resistance of metal components. This treatment is common in the aerospace and automotive industries.
Roughness analysis
During a laboratory roughness analysis, our experts measure the texture of a material's surface and quantify any irregularities. This surface analysis is used to verify specific performance and aesthetic criteria.
Delamination study
The delamination study is used to examine the layers of a composite material or with a coating in order to identify any signs of separation or anomalies. This information determines the structural integrity of composite materials used in aeronautics or construction, for example.
Tomography test
Laboratory tomography testing uses X-rays or other forms of radiography to create three-dimensional images of the inside of an object without destroying it. This method can be used to analyse defects in materials, helping to prevent failures in industries such as energy.
Recherche et développement
Nos prestations d'expertise de surface
Développement et validation de procédé de traitement (fonctionnalisation ou passivation)
Le développement et la validation de procédés de traitement de surface sont fondamentaux pour innover et améliorer les performances des matériaux, en assurant que chaque méthode soit efficace, reproductible et conforme aux normes de qualité exigées. Cette démarche garantit la fiabilité et l'efficacité des traitements appliqués, adaptés aux spécificités de chaque matériau.
Etude de vieillissement
L'étude de vieillissement permet de prédire sa durabilité et sa résistance dans le temps. Il permet notamment d'anticiper les modifications de ses propriétés sous l'effet de facteurs environnementaux et d'usage.
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Accompagnement dans le choix des traitements de surface
Les traitements de surface confèrent aux matériaux un aspect et des caractéristiques particulières suivant la nature du traitement de surface mais également celle du substrat qui va accueillir ce revêtement.
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Formation à la demande en analyse de surface
FILAB vous propose un panel de formations mais il est tout à fait possible de réaliser des formations à la demande.
Our technical resources
For over 30 years, the FILAB laboratory has had the experience and specific analytical equipment to meet the needs of analysis and characterisation of the surface condition of all types of materials (metallic, polymer, ceramic). FILAB uses the following surface analysis techniques:
MEB-EDX
MEB-EBSD
AFM
TOF-SIMS
XPS
Surface characterization applications
medical devices industry
Poor adhesion of a coating on a medical implant
In the medical device industry, problems with the adhesion of antibacterial coatings on titanium implants can lead to batches being rejected.In such cases, the intervention of a laboratory specialising in surface characterisation is essential. Thanks to analyses such as XPS and SEM-EDX, it is possible to identify organic contamination that is invisible to the naked eye. This data can be used to adapt surface treatments and guarantee the conformity of medical devices.
Jewellery industry
Analysis and optimisation of thin films for luxury products
In the luxury goods industry, thin films are used to give products aesthetic and personalised finishes, such as gold or platinum coatings on jewellery. They also offer technical functions, such as scratch resistance for watches via layers of DLC or titanium nitride. To validate their performance, these films are analysed in the laboratory using techniques such as SEM, TEM or AFM. These tools are used to study their morphology, thickness and roughness. The chemical composition is determined using methods such as XPS or DRX.
Our FAQs
What is surface condition analysis?
Surface analysis refers to a set of techniques used to study the physico- chemical analysis aimed at assessing the state, elemental composition, topography and functional properties of a material's surface layers.It helps to understand material/environment interactions, identify critical defects and validate or optimise industrial manufacturing, treatment or coating processes.
Why characterise a surface?
To ensure the quality, performance and conformity of a product in sectors such as health, aeronautics or luxury goods.
How do you assess a laboratory's surface expertise?
A laboratory's surface expertise refers to its ability to analyse and characterise the properties of material surfaces and interfaces. This expertise covers a wide range of analysis and measurement techniques, enabling aspects such as the chemical composition, molecular structure, topography, roughness, morphology, and mechanical and electrical properties of surfaces to be assessed.The aim is to understand how surfaces interact with their environment, which is crucial in many areas of application, including coatings, surface treatments, nanotechnology, energy, electronics and biomaterials.Laboratories with this expertise use advanced equipment, such as scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and other surface analysis methods to obtain detailed information about the surface layers of materials.
What are the objectives of surface expertise in the laboratory?
The surface expertise of a laboratory such as FILAB helps to guide the development of new materials, improve manufacturing processes, solve quality and performance problems, and foster innovation in product design.
What techniques are used to analyse surface condition?
Techniques commonly used in surface analysis include scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction. These techniques provide information on the topography, chemical composition, molecular orientation and mechanical properties of a material's surface.
What are the characteristics of a surface?
Surface characteristics include roughness, cleanliness, chemical composition and topography.
What is the difference between surface and interface?
The surface of a material refers to its outer layer that comes into contact with the environment, such as air or a liquid.The interface, on the other hand, is the area where two different phases or materials meet and interact, such as the boundary between a solid and a liquid or between two solids.
What are the most common faults on material surfaces?
The problems encountered on the surface of a material are linked to its direct exposure to the environment. This includes corrosion, wear and tear, and degradation due to environmental factors such as oxidation and humidity. These conditions lead to changes in the chemical and physical properties of the surface, requiring specific solutions such as surface treatments or coatings to improve the strength and durability of the material and prevent failure.When it comes to interfaces between two distinct materials or phases, it is more a question of adhesion, chemical compatibility, and the transmission of stresses or electrical currents across the interface.This industrial issue is critical in the design of composite materials, electronic devices and multi-material assemblies, where poor interaction at the interface can compromise structural integrity or functional performance.Contact the FILAB laboratory to find out more about the analyses available
How do you assess a laboratory's surface expertise?
A laboratory's surface expertise refers to its ability to analyse and characterise the properties of material surfaces and interfaces. This expertise covers a wide range of analysis and measurement techniques, enabling aspects such as the chemical composition, molecular structure, topography, roughness, morphology, and mechanical and electrical properties of surfaces to be assessed.The aim is to understand how surfaces interact with their environment, which is crucial in many areas of application, including coatings, surface treatments, nanotechnology, energy, electronics and biomaterials.Laboratories with this expertise use advanced equipment, such as scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and other surface analysis methods to obtain detailed information about the surface layers of materials.
How is the surface characterised?
Analysis and characterization of the surface of materials is carried out in the laboratory using specific technical and analytical resources depending on the materials and requirements (contamination, wear, adhesion, etc.).
Our services
Inspection, laboratory analysis and registration of "PMUC" products
Your needs : to have an EDF approved laboratory confirm that your products comply with PMUC regulations
“PMUC” (Products and materials for use in a power plant or “Produits et Matériaux Utilisés en Centrale électrique” in French) labeled products can potentially have corrosive effects on steel if they contain halogenated or sulfurous compounds.To be authorized to go on the market PMUC labeled products must be registered by EDF after analysis have been carried out in an approved laboratory.
The products in question are those used in power stations during production, construction, maintenance or just normal operation. There are 24 categories of “PMUC” labeled products listed by EDF : glues, varnishes/paints, anti-seize compounds, cleaning products, decontamination products, protection products, plastics, joints, products for finding or sealing leaks, abrasives...
Are you looking for a laboratory of registration PMUC products ?
PMUC analysis consists in determining the halogen (Fluorine / Fluorides, Chlorine / Chlorides, Bromine / Bromides) and sulfur contents of products designed to be used in a power station, following EDF protocols specific to each category of products.Once the analysis has been carried out a report is drafted and sent to the client to present the results to EDF for them to grant the product with the PMUC label.
Our PMUC analysis services approved by EDF
FILAB has been approved by EDF to carry out various typological PMUC analysis :Assessment of your product prior to requesting PMUC registrationRegistration testing : Chemical analysis to obtain PMUC registration productsInspections and follow-up analysis of PMUC productsPMUC chemical analysis carried out by FILAB comply with EDF’s D5713/ DJX / RB 90 0295 procedure.Inspections carried out by the laboratory consist in analyzing the halogen (Fluorides F-, Chlorides Cl-, Bromides Br-) and sulfur contents of PMUC labeled products with the aim of confirming their compliance with EDF’s specifications.Did you know ? FILAB is also a member of the Nuclear Valley organization
What does PMUC mean?
PMUC means ‘products and materials used in nuclear power plants’. They correspond to consumables used for the construction, maintenance and operation of nuclear power plants, such as stainless steel, aluminum alloys, and refractory materials.Nuclear power plants operate by harnessing nuclear energy to generate electricity, which requires products and materials capable of withstanding extreme temperatures and pressures, this is why they are subject to strict standards to ensure safety, about products and materials used.
Why do nuclear power plants need PMUC analysis ?
Determining the compliance of products and materials used in nuclear power plants (PMUC) requires laboratory analysis for each collected sample.The analysis verifies if the products meet the specified regulatory requirements. Products and materials used in nuclear power plants must meet stringent quality standards to guarantee the safety of everyone involved in the operation of the plant.The PMUC referenced products are specifically designed to meet the requirements and specifications of nuclear power plants in France.
What are the referenced products and materials used in nuclear power plants ?
Here is a non-exhaustive list of PMUC products affected by the regulations. There are 24 categories of PMUC classified products, including cleaning, decontamination, temporary protection, leak detection or sealing products, anti-seize, plastics, abrasives, paints, adhesives, oils, seals... Each category is characterized by its content of sulfur and halogen species and more specifically fluorine, bromine, chlorine. Construction materials for the plant often include stainless steel, concrete, graphite, and ceramics. Components such as reactors, steam generators, and heat exchangers are also made from heat and corrosion-resistant materials like zirconium, titanium, and stainless steel.Products used, such as lubricants and chemicals Therefore, it is important to stay updated on regulatory updates regarding PMUC (products and materials used in nuclear power plants) to ensure the safety of people and the environment.
About us
Laboratory providing analytical and R&D services
Are you looking for a reliable laboratory to provide analytical services ?
Confronted with the multiplication of industrial challenges and with the increasingly complex issues companies are facing, service providing analytical laboratories are called being upon to assist in providing the experience needed to fulfil various types of requests :Chemical composition analysisCompliance inspectionsNon-compliance of industrial batchesProblems due to impurities, contaminations or pollutantsIncomprehension of a product failureEvaluation of the performance of industrial proceduresThese services can be called upon for various reasons from routine quality control to the implementation of more complex projects such as the analytical development or improvement of procedures.
FILAB, a laboratory providing analytical and R&D services, fulfilling your requests and with tailored support
FILAB provides services for industry relying on its dual expertise in chemistry and materials science, its cutting-edge analytical fleet and the experience of its doctors and engineers to fulfil requests relating to :
Quality Control :
Custom chemical analysisMaterial characterizationSurface analysisFailure analysis : identification of particulates and deposits, fractography, corrosion, adhesive problems…
Analytical Research and Development :
Analytical developmentClient / Supplier litigation supportR&D assistance : literature reviews, reverse engineering services, industrial transposition…Audits and analytical trainingAs an independent, service providing laboratory with a team made up of highly qualified personnel, FILAB guarantees the reliability of its results, a quick turnaround for requests and tailored support for clients. For more information about our laboratory services, feel free to contact us !
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Sectors of activity
Determination of acetaldehyde content found in cosmetic products
Your needs : to determine acetaldehyde found in your cosmetic products in accordance with relevant regulations
Acetaldehyde or ethanal is a chemical substance belonging to the aldehyde family. Acetaldehyde is a colorless liquid, naturally occurring in plants but can also be synthesized.
Found in cosmetic products, particularly perfume, acetaldehyde is used as an additive, deodorant or even as a fragrance.
Acetaldehyde is classified as a toxic substance and a suspected carcinogen. For this reason, its use in cosmetics is highly regulated and limited to low concentrations.
Are you looking for a reliable and reactive laboratory to determine acetaldehyde content in your pharmaceutical products ? Call on FILAB !
FILAB provides analytical services for the determination of acetaldehyde content in your cosmetic products
For over 10 years, FILAB laboratory has been developing a diverse analytical skillset applied to the field of cosmetics. Our laboratory is equipped with a cutting-edge analytical fleet spread over 5 200m² to be able to provide services for the determination of acetaldehyde in cosmetics while fulfilling your criteria relating to product compliance.
FILAB provides tailored services for the analysis of your cosmetic products :
ANALYSES
Analysis and determination of trace amounts of acetaldehyde in your cosmetics using chromatographic techniques : HS-GC-MS, HPLC-UV, GC-MS…
Determination of active ingredients : organic and inorganic UV filters, vitamins…
Analysis of packaging : polymers, composites, glass
Expertise of non-compliances : particulates, deposits, unidentified spikes, degradations…
Compatibility testing (container/contents interactions, extractables and leachables)
Analysis of undesirable substances found in raw materials and finished products : heavy metals, residual solvents, phthalates, bisphenol A…
Determination of preservatives (phenoxyethanol, parabens, chlorphenesin…) by HPLC-UV, HPLC-MS/MS and GC-MS
Analytical validation in accordance with the ISO 12787 standard
Reverse engineering of cosmetic products
Laboratory audits and analytical training
For more information about our services for the determination of acetaldehyde content found in your cosmetic products, feel free to contact us via email at contact@filab.fr or over the phone by calling +33 (0)3 80 52 32 05
Sectors of activity
Forced degradation (stress testing) in a laboratory
Your needs : to carry out a forced degradation study on a pharmaceutical product or active pharmaceutical ingredients (API) as part of pharmaceutical development
Forced degradation studies or stress testing is a stability test used to simulate the changes in the behavior of a pharmaceutical products or active pharmaceutical ingredients. The aim is to highlight the stability of medication over time and to observe the effects of purity and the product’s compliance with standards.
These degradation studies can be performed on both active ingredients and finished products.
Are you looking to cooperate with a reliable and reactive laboratory for your forced degradation studies ? Call on FILAB !
Our solutions : to assist you in testing stability and in conducting forced degradation studies on your pharmaceutical products
FILAB laboratory is able to conduct stability testing services and to carry out forced degradation studies on your pharmaceutical products as part of an R&D project or as part of quality control. Thanks to our cutting-edge analytical fleet spread over 5 200m² FILAB can provide the following services :
Stability testing and forced degradation studies in accordance with the ICH Q1A guideline
Custom chemical analysis to study a product’s stability
Method development and validation
Chemical composition analysis of a product depending on specific environmental conditions (temperature, humidity, exposure to light…) by GC-MS, HPLC or FTIR
Study of Container/Contents interactions
Analysis and identification of impurities
Analysis of active ingredients
Analysis and determination of degradation product
Reverse engineering of degradation products
Reverse engineering of pharmaceutical products
For more information about our services surrounding forced degradation studies, feel free to contact us via email at contact@filab.fr, over the phone by calling +33 (0)3 80 52 32 05 or you can request a free quote online here.
The positive aspects of FILAB
A highly qualified team
Responsiveness in responding to and processing requests
A COFRAC ISO 17025 accredited laboratory
(Litters available on www.cofrac.com - Accreditation number: 1-1793)
A complete analytical park of 5 200m²
Tailor-made support
A SAFRAN approval
Our services
Laboratory study of plasticizer migration phenomena
Are you looking to study the migration of plasticizers found in your packaging materials ?
Plasticizers, including phthalates, are oily, odorless liquids that are regularly used to improve the physical properties of plastic materials. These plasticizers can be dangerous for human health and the environment if they are released or if they leach into a product. The EU and the FDA have regulated the use of plasticizers to limit such risks. As an industrialist, you are required to meet these requirements to avoid any product degradation and any health risks for your customers. A study of plasticizer migration into your product is therefore essential to better understand these phenomena.
FILAB laboratory is able to provide you with its analytical equipment to study the risks of plasticizer migration in your packaging materials
For over 30 years, FILAB has been developing a wide analytical skill set in relation with plasticizer migration phenomena. Our laboratory is equipped with a cutting-edge analytical fleet spread over 5 200m² and offers a high level of technical skill to be able to provide services fulfilling our clients’ compliance criteria as part of plasticizer migration testing.FILAB is able to provide tailored services for the analysis of your packaging materials and of hazardous substances :Migration testing on packaging after an accelerated aging procedureDetermination of unwanted substances, namely plasticizers found in formulations by GC-MS, LC-MS, HS-GC-MS, FTIR…Determination of phthalates and other substances of concern : heavy metals, bisphenol A, solar filters…Physicochemical characterization of packaging materialsReverse engineering of cosmetic products
Our services
Identification and determination of additives in your polymers
An additive is a chemical substance incorporated into polymers to improve their final properties. Additives can be used to have a positive effect on production, storage, treatment, during and after a product’s use.These additives can be plasticizers, dyes, solvents, lubricants, etc.As part of the development or optimization of a product, after a change in regulations or following a product failure, you are looking to characterize and determine the presence of additives in your polymers with support from a specialized laboratory.
FILAB is able to provide you with our analytical equipment and the expertise of our engineers for the determination and analysis of additives in polymers
With the use of complementary analytical tools and our dual expertise in chemistry and materials science, FILAB is able to carry out physicochemical analysis making it possible to characterization the presence of additives in your polymers :Identification of additives found in a polymerDetermination of additive content in a polymerVerification of the composition of a polymer compared with its SDS, namely its additive contentAccelerated aging testsReverse engineering of polymers to measure the presence of additivesDevelopment and analytical validation specific to additives To carry out these different services, FILAB laboratory uses a wide range of analytical techniques, such as :Thermal analysis by DSC or TGAChromatographic analysis (GC-MS or HPLC) to identify volatile additivesSpectrometric analysis (FTIR, ICP-MS and ICP-AES) to measure the presence of an additive in a polymerWith three levels of services – analysis, expertise and R&D support – FILAB assists companies from all sectors and of all sizes in overcoming their industrial challenges by sharing its technical know-how and the wealth of experience of its team with its clients.
Sectors of activity
Laboratory analysis of pharmaceutical formulations
Why monitor the quality of your pharmaceutical formulations ?
The pharmaceutical industry is one of the more stringent industries in terms of regulations. For this reason, many industrial pharmaceutical producers, of products intended for either animal or human consumption, are faced with numerous quality requirements.Regulations surrounding the quality of pharmaceutical formulations are not just applied during a product’s lifecycle, but also during development and marketing phases. All these quality control tests on pharmaceutical formulations are referenced in Pharmacopeias (USP, EP).The non-compliance of a pharmaceutical formulation (impurities, API/excipient interactions…) could cause the product to not be authorized to be put to market or to be called back.Are you looking for a reliable and reactive for the analysis of pharmaceutical formulations ? Call on FILAB !
FILAB is able to assist you in analyzing the compliance of your pharmaceutical formulations
FILAB offers pharmaceutical industrialists with a high level of skill and a cutting-edge analytical fleet to provide services fulfilling their criteria in terms of compliance to standards relevant to all kinds of galenic pharmaceutical formulations.FILAB laboratory is the only French laboratory to be ISO 17025 accredited (www.cofrac.fr accreditation n°1-1793) for the analysis of elemental impurities in pharmaceutical matrices and for the analysis of pharmaceutical formulations in accordance with GMPs.To reliably and precisely resolve these problems, FILAB offers tailored support for the analysis of your pharmaceutical formulations :Chemical analysis of your pharmaceutical formulations by GC-MS, LC-MS, ICP…Analysis of pharmaceutical formulations following ICH and VICH guidelinesDetection of elemental impurities in your pharmaceutical formulations by ICP-MS or ICP-AESAnalysis of particulates in your pharmaceutical formulations (troubleshooting) by MEB-EDX, FTIR, LC-MS/MSReverse engineering of your pharmaceutical formulationsExtractables and leachables (E&L) testing For more information about our analytical services relating to pharmaceutical formulations, feel free to contact us via email at contact@filab.fr, over the phone by calling +33 (0)3 80 52 32 05 or request a free quote online here.
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Sectors of activity
Laboratory analysis of pharmaceutical powder
Are you looking to analyze your pharmaceutical powder or raw materials in accordance with relevant regulations?
According to the European Pharmacopeia, a pharmaceutical powder is defined as “as a dry, solid substance, composed of finely divided drugs with or without excipients and intended for internal or external use. It is a solid substance in finely divided state typically obtained by crushing, grinding, or comminuting”.
Powdered medications can be found in various forms : pills, effervescent powders, inhalable products, powders intended for injectable solutions… Powdered medications are mainly administered orally, nasally or by inhalation.
The quality requirements of powdered medications can need to be analyzed both during the process of putting a medication to market and at any point during a product’s lifecycle. Assurance of the high quality of powders leads pharmaceutical industrialists to carry out numerous quality control tests in accordance with well-defined references such as pharmacopeias.
Our solution : to assist pharmaceutical producers in analyzing their products (raw materials and finished products)
FILAB offers pharmaceutical industrialists a high level of technical skill and a cutting-edge analytical fleet to provide them with services fulfilling their criteria relating to product compliance and adherence to regulatory standards for all kinds of powdered medications.
To reliably and precisely resolve these problems, FILAB provides tailored support for the analysis of pharmaceutical powders :
Purity testing on active ingredients
Chemical composition analysis of your pharmaceutical powders by GC-MS, LC-MS, ICP…
Polymorphism testing
Physicochemical testing : PSD, flowability, morphology, porosity…
Detection of elemental impurities in your pharmaceutical powders (ICH Q3D) by ICP-MS or ICP-AES
Reverse engineering of your pharmaceutical powders
Problem solving : odor, discoloration, degradation…
The positive aspects of FILAB
A highly qualified team
Responsiveness in responding to and processing requests
A COFRAC ISO 17025 accredited laboratory
(Litters available on www.cofrac.com - Accreditation number: 1-1793)
A complete analytical park of 5 200m²
Tailor-made support
A SAFRAN approval
Sectors of activity
Laboratory analysis of pharmaceutical products intended for animal consumption
Your needs : to inspect the quality of your pharmaceutical products intended for animal consumption
Just as is the case for products intended for human consumption, animal health industrialists are also confronted with drug quality standards. These quality requirements, which apply to both the marketing of a drug and its life cycle, require the manufacturers of animal health products to carry out several quality-control tests.The non-compliance of pharmaceutical products intended for animal health (presence of pollutants, container/contents interactions) could lead to a product being called back or for a product to not be authorized to go to market.To overcome these technical challenges, you are looking to cooperate with a reliable and reactive analytical laboratory.
Our solution : to assist animal healthcare industrialists in analyzing the quality of pharmaceutical products
FILAB offers animal healthcare industrialists a high level of technical skill along with a cutting-edge analytical fleet to be able to provide services fulfilling their criteria in terms of compliance with relevant standards applicable to all kinds of galenic medications
Did you know that
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FILAB laboratory is the only French laboratory to have ISO 17025 accreditation (www.cofrac.fr – accreditation n°1-1793) for the analysis of elemental impurities in pharmaceutical matrices and carries out analysis of medications in line with GMPs.To solve these problems, FILAB provides tailored support for analysis of pharmaceutical products intended for animal consumption :
our services
Chemical analysis of your medications by GC-MS, LC-MS, ICP…
Detection of elemental impurities in your medications (VICH) by ICP-MS and ICP-AES
Reverse engineering of your animal medications
Analysis following VICH guidelines
Particulate analysis of your medications (troubleshooting) by SEM-EDX, FTIR, LC-MS/MS…
Extractible and leachable testing
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Our services
Laboratory analysis of Polyvinyl chloride (PVC) materials
Your needs: to verify the quality and the performance of your polyvinyl chloride materials
Polyvinyl chloride or PVC is a widely used thermoplastic polymer which can often be found as a white, odorless powder. This powder can be used with different additives and take on many different shapes.After setting, PVC can be either solid or flexible, transparent or opaque, colorless or dyed.PVC is widely used, most notably in construction, packaging, clothing and in automobiles…Chemical analysis and characterization of polyvinyl chlorides is an essential step to controlling their transformation into usable products and in preventing the apparition of potential defects. Analysis is manly used to :Determine the chemical composition of polyvinyl chloridePhysiochemically and thermally characterize PVC materials : density, molecular mass, thermal analysis, calorimetric analysis…Identify the chemical nature of a PVC sample and its additivesDetermine the mineral filler being used (chalk, talc…)To characterize a defect (adhesive problem, disbonding, inclusions…)Verify that a finished product complies with standardsWorking with plastics, as producers of raw materials or as manufacturers using plastics, you are looking to cooperate with a reliable laboratory offering analysis with high added technical value to analyze and characterize your PVC materials.
Our solution: to assist you in analyzing and characterizing your polyvinyl chloride samples
By combining analytical tools specific to polyvinyl chlorides with our precise and reliable scientific knowledge, FILAB laboratory is able to assist industrialists in optimizing their production processes, in researching possible material substitutions and in resolving problems caused by defects found in PVC materials.With extensive experience in analyzing polyethylene and being equipped with a diverse analytical fleet, FILAB laboratory is able to provide the following services :Characterization of PVC materials : physicochemical and thermal properties by DSC, TGA, TGA-FTIR, GPC, NMR, SEM and FTIRCustom chemical analysis : detection of additives by GC-MS, Py-GC-MS, LC-MS/MS, IC…Detection of impurities : heavy metals, residual solvents, degradation products, contaminations…Reverse engineering of polyvinyl chloride materialsDetermination of molecular mass by GPCCompatibility testing between PVC materials and various fluids
Les + FILAB
Une équipe hautement qualifiée
Une réactivité de réponse et de traitement des demandes
Un laboratoire accrédité COFRAC ISO 17025
(Portées disponibles sur www.cofrac.com - N° accréditation : 1-1793)
Un parc analytique complet de 5 200m²
Un accompagnement sur-mesure
Our technical resources
Laboratory analysis by RAMAN Spectroscopy
You would like to carry out a RAMAN spectroscopy analysis to identify the chemical and molecular composition of your materials and products
What is a RAMAN analysis?
Raman spectroscopy analysis is a non-destructive analytical technique used to identify the chemical composition and molecular structures of a sample.The method is based on the inelastic scattering of light (Raman effect) when a laser interacts with the molecules in the sample.Raman spectroscopy is particularly popular for the analysis of organic and inorganic materials, and for the study of complex substances without the need for specific sample preparation.Unlike other techniques such as FTIR, Raman spectroscopy can be used to analyse symmetrical bonds that are difficult to detect in other ways, making it more complementary in many industrial and scientific contexts.
What are the advantages of Raman analysis?
The Raman spectroscopy analysis technique offers a number of advantages:
It allows precise identification of the chemical compounds in a sample, including those present in small quantities.
This is a non-destructive analysis technique that allows samples to be analyzed without damaging them.
It can be used on many types of samples: solid, liquid or gaseous.
It provides comprehensive information on both molecular structure and the dynamics of chemical bonds.
Elle est particulièrement utile pour les applications nécessitant une haute résolution spatiale, comme l’analyse de micro-échantillons, la détection de contaminants ou l’étude des polymères complexes.
When should Raman spectroscopy be preferred to FTIR spectroscopy?
Raman spectroscopy is recommended in the following cases:Analysis of carbon bonds in aliphatic or aromatic rings.Study of bonds that are difficult to identify with FTIR, such as 0-0, S-H, C=S, N=N, C=C.Examination of particles in solution to explore polymorphism.Analysis of low-frequency modes, for example in inorganic oxides.Study reactions in aqueous media, where FTIR is less suitable.Observation of complex reactions requiring analysis through windows (high-pressure catalytic reactions, polymerisations).Analysis of three-dimensional networks at low frequency.Monitoring two-phase and colloidal reactions to identify triggers or end points.FTIR spectroscopy is preferable for :Liquid phase reactions.Samples with reagents, solvents or fluorescent species that interfere with Raman.Bonds where dipolar modifications are important, such as C=O, O-H, N=O.Reactions where the reagents are poorly concentrated.Cases where the Raman spectrum is disturbed by dominant solvent bands.Observation of infrared-sensitive intermediates.The complementary nature of the two techniques makes them powerful and indispensable tools in chemical and industrial analysis.
The principles of Raman analysis
Raman analysis is a non-destructive spectroscopic technique using a laser as the light source. The resulting Raman spectrum, showing the intensity of light scattered at different wavelengths, is analyzed to identify the compounds present. Each substance has a characteristic Raman spectrum due to its chemical bonds and molecular structure.The Raman technique can be applied to a variety of samples, including solids, liquids and gases, and test conditions can be adapted, such as temperature and pressure.Raman spectroscopy offers a unique ability to detect subtle variations in molecular structures and chemical bonds, revealing information invisible to other methods.
Why carry out a RAMAN analysis?
Raman analysis aims toidentify the chemical composition of samples and provide detailed information about their molecular structure and chemical bonds. Thanks to its sensitivity to different molecular configurations, Raman analysis is able to detect fine nuances in chemical composition, providing an in-depth understanding of the physical and chemical properties of the materials studied.
FILAB laboratory is able to assist industrialists with their various problems by providing RAMAN Spectroscopy analysis services
Whatever your industrial sector (Chemicals, Pharmaceuticals, Cosmetics, Food) or the application of your products, FILAB ‘s RAMAN analysis expertise and services will enable you to analyze even small areas of contamination. This technique can also be used to identify materials and measure stresses.Raman spectroscopy is also essential for in situ analyses, such as monitoring chemical reactions, understanding reaction mechanisms or assessing materials subjected to thermal or mechanical stress.Our equipment includes advanced spectrometers with adjustable lasers (532, 785 and 1064 nm), guaranteeing increased sensitivity even in complex analytical environments.
Our technical resources: RAMAN
Raman analysis, as a method of spectroscopy, is a cutting-edge method characterised by several technical aspects.It uses a high-intensity laser, whose interaction with the sample causes light to be scattered. Most of this light is scattered elastically, known as Rayleigh scattering, while an inelastic portion, crucial to the analysis, is known as Raman scattering. The scattered photons are analyzed by a spectrometer, which determines the intensity of the light at different wavelengths, revealing the Raman spectrum specific to the sample. In addition, the integration of Raman microscopy makes it possible to obtain detailed images of the distribution of chemical compounds on a microscopic scale.
Industrial sectors where RAMAN technology is used
The characteristics obtained make Raman spectroscopy extremely effective for chemical analysis and applicable in various fields such as materials characterization and pharmaceutical analysis.RAMAN analysis can be used in the following applications:Industrial materials: In industry, it is used for quality control, detecting contaminants, or studying the properties of materials such as polymers, ceramics, etc.Pharmaceuticals and cosmetics: Raman spectroscopy is used to analyse the composition and verify the quality of drugs and cosmetics.In short, Raman analysis is favoured for its versatility, its ability to provide detailed information without damaging the sample, and its applicability to a wide range of materials in different fields.
Our RAMAN analysis services
The FILAB laboratory covers an area of 5,200 m² and provides the following services in particular:
Surface inspection of a material
Analysis of microplastics in water using RAMAN Spectroscopy
Particle or deposit analysis
Identification of chemical composition
Study of the presence of graphene in surgical masks using RAMAN spectroscopy
FAQ
What is Raman spectroscopy analysis?
Raman spectroscopy is an analytical technique used to identify and characterise molecules. It measures changes in the inelastic scattering of monochromatic light, i.e. when a photon interacts with a molecule and causes it to vibrate. This interaction produces an optical signal that contains information about the molecular structure, such as bond strength, molecular symmetry and conformation. By deciphering this signal, Raman analysis obtains information about the composition of the sample being analyzed.Raman spectroscopy has become increasingly important for many different applications due to its ability to provide rapid and reliable analysis without damaging or altering samples, making it ideal for life science research and quality control and assurance testing in industry. The technique also provides information on the crystallinity, purity, phase and homogeneity of the sample. By combining various spectroscopic techniques such as infrared spectroscopy, X-ray diffraction and thermogravimetric analysis with RAMAN spectroscopy, researchers can obtain more detailed structural information about the analyzed sample. RAMAN analysis is a powerful tool for research in fields such as materials science and biochemistry. In addition to laboratory applications, Raman spectroscopy is also used for clinical diagnosis and space exploration.Raman spectroscopy is also advantageous because of its portability; it requires minimal sample preparation compared to other analytical techniques and can be performed using portable instruments. It is therefore ideal for field work or on-site measurements, as the standard operating conditions are very good.
Which industries are interested in a RAMAN analysis?
Raman spectroscopy plays an important role in many industries and can be used to analyse a wide range of sample types. Industries such as pharmaceuticals, food and beverage, cosmetics, materials science and biochemistry are just some of the areas that benefit from this technology. Raman analysis allows researchers to quickly identify unknown compounds or confirm molecular structures in a variety of samples. Raman spectroscopy is useful for characterising catalysts and studying chemical reactivity. Its portability makes it ideal for field work or on-site measurements. The use of Raman spectroscopy in quality control and quality assurance testing has increased dramatically in recent years due to its accuracy, reliability and cost effectiveness.
How does a RAMAN analysis work?
Raman spectroscopy is based on the inelastic scattering of monochromatic light. When a sample is illuminated by a laser beam, certain particles interact with the molecules present and cause them to vibrate. This vibration produces an optical signal that contains information about the molecular structure. By analysing this signal, it is possible to obtain information about the composition and properties of the sample being analysed. The Raman spectrum produced by this process can be used to identify unknown compounds or confirm molecular structures. The use of filters and software algorithms allows weak signals to be amplified and background noise to be reduced, leading to more accurate results. Finally, data analysis techniques such as principal component analysis are used to interpret complex Raman spectra.
Why use raman analysis in the pharmaceutical sector?
L'analyse Raman est largement utilisée dans le secteur pharmaceutique pour ses capacités de caractérisation rapide et non destructive. Voici ses principales applications :> Identification des matières premières : Pour assurer la qualité des médicaments.> Contrôle de qualité : Détecte les impuretés et confirme la composition chimique des produits finis.> Analyse des formes posologiques : Examine la distribution des ingrédients actifs dans diverses formes comme les comprimés et les gélules.> Développement de formulations : Optimise les formulations en analysant les interactions entre composants.> Étude de la stabilité : Surveille les changements chimiques des médicaments sous différentes conditions de stockage.Ces utilisations font de l'analyse Raman un outil essentiel pour améliorer la sécurité et l'efficacité des produits pharmaceutiques.
What type of material should be analyzed by raman?
Raman analysis is highly versatile and can be carried out on a wide variety of samples and materials in many fields:Crystals and minerals: Used to study crystal composition and structure.Pharmaceuticals: As mentioned above, for raw material identification, quality control and dosage form analysis.Polymer materials: Analysis of the chemical and structural properties of plastics and other polymers.Nanomaterials : Assessment of the composition and properties of nanotubes, nanoparticles, etc.Semiconductor materials: Analysis of the structure and defects of materials used in electronics.Chemicals: Monitoring of chemical reactions, identification of pure chemical compounds or mixtures.Thanks to its non-destructive approach and its ability to provide detailed information on chemical composition, Raman spectroscopy is applicable to almost all types of materials.
Can raman analysis be carried out on metals?
Raman analysis on metals is possible but complex due to the specific optical characteristics of these materials. Metals reflect light strongly, which can be problematic for Raman spectroscopy as much of the laser radiation used is reflected back rather than scattered in a way that is useful for analysis.In addition, metals tend to produce a strong fluorescence signal when exposed to the laser, which can mask the often weaker Raman signal. Another problem is localised heating of the sample due to laser absorption, which can alter the results of the analysis. Despite these challenges, specific techniques and instrument configurations can be used to minimise these effects and enable efficient Raman analysis of metallic samples.
What should I choose between FTIR and RAMAN infrared analysis?
The choice between Raman spectroscopy and FTIR depends on the sample and the type of analysis. FTIR is best suited to polar materials such as proteins and plastics with O-H bonds, but water can interfere. Raman is ideal for non-polar substances, carbon structures (graphite, graphene), and polymers, and allows analysis of aqueous samples without complex preparation.
What is the difference between Raman spectroscopy, Raman spectrometry and Raman microscopy?
Raman spectroscopy is a non-destructive analysis technique used to study the chemical and structural composition of materials by measuring the inelastic scattering of light, known as the Raman effect.Raman spectrometry is used to perform quantitative analyses to measure the concentrations of components present in a sample.Raman microscopy is used to create detailed chemical maps on a microscopic scale, useful for studying complex samples such as composites, polymers or nanomaterials.
What are the principles of Raman spectroscopy?
Raman spectroscopy is based on the principle of inelastic light scattering, known as the Raman effect. When a monochromatic laser beam is directed onto a sample, most of the light is elastically scattered (Rayleigh scattering) without any change in energy. However, a small fraction of the light interacts with the molecular vibrations of the sample, causing a slight energy shift in the scattered light. These energy shifts correspond to the specific vibrations of the chemical bonds in the molecules, making it possible to construct a unique spectrum for each material. This non-destructive method is invaluable for identifying chemical composition, studying molecular structures and analysing a variety of materials, such as polymers, crystals, and organic and inorganic compounds.
When should analysis be carried out using raman spectroscopy?
Raman spectroscopy is used in a variety of industrial contexts and sectors because of its ability to provide detailed, non-destructive information about the chemical composition and molecular structure of materials.In the pharmaceutical industry, it is used for analysis of active ingredients and quality control of drugs.In the materials sector, it is used to study polymers, composites and nanomaterials to check their uniformity and properties.The petrochemical industry uses this technique to analyse hydrocarbons and catalytic reactions.
What kind of industrial problems can raman spectroscopy solve?
Raman spectroscopy addresses a range of industrial problems, providing precise quality control and detecting impurities, particularly in the pharmaceutical and cosmetics sectors.It checks the homogeneity of materials, studies composites and nanomaterials to optimise their properties, and characterises chemical reactions in the development of new products.
Sectors of activity
Laboratory analysis of cosmetic ingredients
Your needs : to analyze and quantify your cosmetic ingredients as part of regulatory inspections
What is a cosmetic ingredient?
Acids, preservatives, natural extracts, oxides, milk… cosmetic products are made up of a wide range of ingredients depending on their application and their benefits. However, some ingredients can have adverse effects on health based on dosage and are therefore subject to specific regulations.Particular attention is paid to endocrine disruptors (parabens, phthalates, glycol esters, etc.) and nanomaterials.
The constraints faced by cosmetics manufacturers
Cosmetics manufacturers are obliged to ensure the quality of their products by complying with current legislation and carrying out regular checks. In this context, the use of a specialised control laboratory is your guarantee of conformity, efficiency and safety in the manufacturing process of your cosmetic products.
The FILAB laboratory can help you analyse and dose your cosmetic ingredients
Why choose FILAB for cosmetics analysis?
The FILAB laboratory supports manufacturers in the cosmetics industry in the analysis, dosing and control of cosmetic ingredients. With its state-of-the-art analytical facilities, the FILAB laboratory team offers a wide range of quality services :
Analysis of active ingredients
Allergen identification
Analysis of packaging (migration study)
Characterization of nanomaterials in accordance with EC Cosmetics Regulation n°1223-2009
Determining traces of parabens in your cosmetic products
Characterization of chemical impurities
Cosmetic ingredient stability studies
FILAB: ISO 17025 accredited for physico-chemical analysis of cosmetic products
FILAB is ISO 17025 accredited by COFRAC for the analysis of heavy metals, phthalates, 1,4-dioxane and bisphenol A in cosmetic products.
More information
our technical resources for cosmetic analysis
Organic chemical analysis: GCMS, Py-GCMS, LC-MSMS, GPC, NMR, FTIR
Inorganic chemical analysis: ICP, XRD, CI
Thermal analysis: TGA, DSC
Metallurgical analysis: ICP, SEM-FEG EDX, OES
Powder analysis: XRD, SEM-FEG EDX, BET
Surface analysis: SEM-FEG EDX, XPS, TOF-SIMS
What ingredients are used in the manufacture of cosmetic products?
A wide range of ingredients can be used in cosmetic products. The most commonly used ingredients are as follows:1. Water2. Vegetable or mineral oils3. Emollients (to soften the skin)4. Thickening agents5. Surfactants (for cleaning)6. Preservatives7. Fragrances and flavourings8. Dyes9. Moisturisers10. Vitamins and antioxidants11. Sunscreens12. Specific active agents (such as hyaluronic acid, vitamin C, etc.)
What are the regulations on cosmetics?
In Europe, cosmetics are governed primarily by Regulation EC 1223/2009, which lays down safety standards and requirements for the marketing of cosmetic products.
Why have your cosmetics analysed?
Cosmetics manufacturers are required to have their products analysed for a number of reasons:Consumer safety: Manufacturers need to analyse their cosmetic products to ensure that they are safe for consumers. For example, by detecting toxic or allergenic substances that could cause health problems for consumers.Regulatory compliance: Regulatory authorities require tests to ensure that your products comply with current safety and labelling standards.Product quality: analyses ensure that your products meet the quality standards defined upstream, and reinforce your company's reputation.Development and improvement: laboratory tests can reveal areas for improvement in the formulation of your products, for example in terms of efficacy or stability.Consumer confidence: by carrying out analyses on your cosmetics and publishing the results, you boost consumer confidence. They can be sure that your products are safe and effective.
Our services
Laboratory measurement of osmolality
FILAB's laboratory measurement of osmolality is an essential chemical analysis service, particularly vital for sectors like pharmaceuticals and cosmetics. This analysis helps ensure product safety and efficacy by measuring the concentration of solutes in a solution, which can affect product stability and performance. FILAB employs advanced methodologies to provide precise osmolality measurements, aligning with strict industry standards to support client needs in quality control and regulatory compliance.
Osmolality
Osmolality is a concentration that can be measured after osmosis has occurred. Osmosis is a physical law corresponding to the passage of a solution from a hypotonic medium to a hypertonic medium through a semipermeable membrane. Osmolality this therefore defined as the number of osmoles of solutes per kilogram of solvent, measured in osmol/kg.Osmolality is used because the volume of solvent stays constant in any conditions (temperature, pressure, etc.) . FILAB laboratory realise mesurement of osmolality.
Measurement of osmolality for the cosmetics industry
In the cosmetics industry, osmolality measurements can be needed to measure the effectiveness of active ingredients. While making a cosmetic crème, the osmolality of raw materials can give an indication of the quantity of particles capable of seeping through semipermeable cell walls. It is therefore possible to determine if a crème containing the active ingredient will be effective or not. It is also possible to determine if the active ingredient disturbs the balance in a cell, which would disqualify the sample.As an industrialist in the cosmetics industry, you are looking to measure the osmolality of your solutions.
Measurement of osmolality for the pharmaceutical industry
Osmolality therefore applies to any element (ion, molecule) capable of attracting water molecules though a membrane. That is why this property is often sort after for a better tolerance (ex. injectable solutions).The European Pharmacopeia 2.2.35 “Osmolality Standards USP 785” describes the principle behind analytical methods, provides a clear and detailed description of a sampling procedure et provides precision requirements for sampling.FILAB laboratory is able to assist you in measuring osmolality in accordance with the European Pharmacopeia
FILAB is able to measure osmolality in its laboratory and can assist you with your analytical needs
FILAB is an independent laboratory situated in Dijon, France and can assist you in measuring osmolality to resolve your quality, safety and performance problems.Our experts provide multiple analytical services centered around osmolality measurements :
our services
Osmolality measurements in accordance with the European Pharmacopeia
Osmolarity measurements
Detection of elemental impurities in excipients in accordance with the USP 233 (ICH Q3D)
Analytical development and validation of methods for quantifying substances in accordance with various standards : ICH, USP, EP, ISO…
Expertise to understand osmolality differences between samples
Particulate count and analysis
Compatibility testing between active ingredients and excipients
Reverse engineering of finished products
What is the difference between osmolality and osmolarity measurement ?
Osmolality and osmolarity are both measurements that refer to the concentration of solutes in a solution, but they are measured in different ways. Osmolality is a measure of the total number of particles in a solution per unit of solvent, typically expressed as osmoles per kilogram of solvent (osmol/kg). Osmolality is determined by measuring the freezing point depression of the solution using an osmometer. This method takes into account all solutes present in the solution, regardless of whether they dissociate in water or not. Osmolarity, on the other hand, is a measure of the total number of particles in a solution per unit of volume of solution, typically expressed as osmoles per liter of solution (osmol/L). Osmolarity is calculated based on the concentrations of individual solutes and their contributions to the overall osmotic pressure of the solution. This method assumes that all solutes in the solution are fully dissociated in water. The main difference between osmolality and osmolarity measurement is the way they take into account the presence of non-dissociating solutes (such as urea), which contribute to osmolality but not osmolarity. Osmolality is considered to be a more accurate measure of the effective osmotic pressure of a solution, while osmolarity is useful for calculating the expected movement of water across cell membranes. In summary, osmolality measures the total number of particles in a solution per unit of solvent, while osmolarity measures the total number of particles per unit of volume of solution.
How to measure osmolarity ?
Osmolarity can be measured using several methods, including: Freezing point depression: This method involves measuring the freezing point depression of a solution compared to a pure solvent. Osmometers are specialized instruments that use this method to calculate the osmolarity of a solution based on its freezing point depression. Vapor pressure: Vapor pressure osmometry measures the decrease in vapor pressure caused by the presence of solutes in a solution. This method is commonly used for measuring the osmolarity of biological fluids such as blood and urine. Calculation: Osmolarity can also be calculated based on the concentrations of individual solutes in a solution, using the formula: Osmolarity = (sum of [solute] x number of particles per molecule) / volume of solution For example, a 0.9% saline solution contains 9 grams of NaCl per 1000 ml of solution. The osmolarity of NaCl is 2, so the osmolarity of the solution can be calculated as: Osmolarity = (9 g/L x 2) / 0.1000 L = 180 Osm/L Conductivity: Another method for measuring osmolarity is by measuring the electrical conductivity of a solution. The conductivity of a solution is proportional to the concentration of ions present, which can be used to calculate the osmolarity.Overall, choosing how to measure osmolarity depends on the type of solution being tested and the equipment available in the chemical analysis laboratory.
How to know if I need osmolality or osmolarity measurement ?
Whether to measure osmolality or osmolarity depends on the type of sample being tested and the purpose of the test. When making a request to a chemical analysis laboratory, it is important to provide as much information as possible about the sample being tested and the purpose of the analysis. Based on this information, the laboratory professionals can recommend whether osmolality or osmolarity measurement is more appropriate for the specific needs of the experiment or analysis. Osmolality measurement is often preferred in clinical settings and for biological samples such as blood, urine, and other bodily fluids, as it is a more accurate measure of the solute concentration in a solution. This is because osmolality is not affected by changes in temperature or pressure, which can affect osmolarity measurements. Additionally, certain solutes present in biological samples, such as urea, contribute to osmolality but not osmolarity, making osmolality a more comprehensive measure of solute concentration. On the other hand, osmolarity may be more appropriate for solutions with well-characterized solutes, such as salt solutions used in cell culture. In these cases, specific solutes are known, and their contributions to the total osmotic pressure can be accurately calculated using osmolarity measurements. Ultimately, the choice between osmolality and osmolarity measurements depends on the specific needs of the experiment or analysis being conducted. If you are unsure which measurement to use, consulting with a laboratory professional or an expert in the field can help determine the best approach.
