As a biopharmaceutical manufacturer, you are looking to carry out glycosylation analysis
What is glycosylation?
Glycosylation is an essential biological process in which sugar chains (glycans) are attached to proteins or lipids. This post-translational modification (PTM) plays a key role in the structure, stability and function of biomolecules. It is particularly critical in the biopharmaceutical field, where it influences the efficacy and immunogenicity of biological medicines, notably monoclonal antibodies (mAbs) and therapeutic proteins.
Why carry out a glycosylation analysis?
Glycosylation analysis is essential for guaranteeing the quality and performance of biomedicines. It is used to check compliance with international regulatory requirements such as those of the EMA, FDA and ICH. Analysis also helps to assess the stability of biomolecules throughout their development and production, ensuring optimal performance.
In biomanufacturing, identifying and controlling glycosylation profiles helps to optimise manufacturing processes and improve the yield of biopharmaceutical products. Finally, this analysis enables the detection of structural variations that could affect the therapeutic efficacy and safety of products administered to patients.
FILAB supports biopharmaceutical companies in glycosylation analysis
Why choose FILAB for glycosylation analysis?
FILAB, a laboratory of analytical expertise, offers comprehensive services for glycosylation analysis. We offer a range of customised methods to assess the properties of proteins or lipids, tailored to the specific needs of each customer.
Our glycosylation analysis services
Glycan structure analysis
Extraction and purification of glycans
Separation and identification of glycans
Glycan profiling
Characterization of glycans
Quantification of glycosylated structures
Separation by capillary electrophoresis
Analysis of protein glycosylation
Determination of glycosylation sites
Comparison of production batches
Study of glycoform heterogeneity
Cutting-edge techniques for measuring physico-chemical properties
